Gene: F2R

2149
CF2R|HTR|PAR-1|PAR1|TR
coagulation factor II thrombin receptor
protein-coding
5q13.3
Ensembl:ENSG00000181104 MIM:187930 Vega:OTTHUMG00000131299 UniprotKB:P25116
NG_032906.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.935e-1 (AD)  1.290e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCSK50.706
ACADL0.704
CNTNAP30.678
ZBTB100.672
ERLIN20.664
DENND4C0.658
ATP10D0.655
TIGD40.655
EVC0.652
MDFIC0.65

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL22A1-0.268
RHO-0.266
MYCNOS-0.265
AP1M2-0.255
PIP5KL1-0.253
C10orf67-0.249
CREB3L1-0.245
GALNT14-0.239
SOHLH1-0.238
DLK2-0.238

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00086StreptokinaseBiotechDrug9002-01-1Approved|InvestigationalTarget
DB05361SR-123781ASmall Molecule-InvestigationalTarget
DB09030VorapaxarSmall Molecule618385-01-6ApprovedTarget
DB11300ThrombinSmall MoleculeApproved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of F2R mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of F2R mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of F2R mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of F2R mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of F2R mRNA"20702594
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of F2R mRNA"20816883
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of F2R mRNA"23196670
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]"23452621
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of F2R mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of F2R mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of F2R mRNA12419474
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of F2R mRNA]"26546572
C5130035-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione"5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of F2R mRNA"17409431
D000082AcetaminophenF2R protein results in increased susceptibility to Acetaminophen17654741
D020106AcrylamideAcrylamide results in increased expression of F2R mRNA28959563
D000242Cyclic AMP[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]22207716
D000242Cyclic AMP[C186 65 binds to and results in increased activity of F2R protein] which results in decreased chemical synthesis of Cyclic AMP22207716
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of F2R mRNA22100608
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of F2R mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of F2R mRNA17023530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of F2R mRNA16483693
D001151ArsenicArsenic affects the expression of F2R mRNA18414638
C006632arsenic trioxidearsenic trioxide results in increased expression of F2R mRNA22535156
D001241AspirinAspirin results in decreased expression of F2R protein15140583|1538105
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of F2R protein"15381054
D001280AtrazineAtrazine results in decreased expression of F2R mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of F2R mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of F2R mRNA19770486
D004958EstradiolEstradiol results in decreased expression of F2R mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of F2R mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of F2R gene28505145
C074619bivalirudinbivalirudin results in decreased activity of F2R protein19124943
C018475butyraldehydebutyraldehyde results in increased expression of F2R mRNA26079696
C090291C186 65[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]22207716
C090291C186 65[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]22207716
C090291C186 65[C186 65 binds to and results in increased activity of F2R protein] which results in decreased chemical synthesis of Cyclic AMP22207716
C090291C186 65C186 65 binds to and results in increased activity of F2R protein22207716
D019256Cadmium ChlorideCadmium Chloride results in increased expression of F2R mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of F2R mRNA25993096
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of F2R mRNA18654764
D002118Calcium[Peptides results in increased activity of F2R protein] which results in increased abundance of Calcium15086339
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of F2R mRNA17484886
D002251Carbon TetrachlorideF2R protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]17962354
D002251Carbon TetrachlorideF2R protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]17962354
D002251Carbon TetrachlorideF2R protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP2 protein]17962354
D002251Carbon TetrachlorideF2R protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]17962354
C100187chloropicrinchloropicrin results in increased expression of F2R mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of F2R gene20938992
C055162clopidogrelF2R gene SNP affects the susceptibility to clopidogrel16194864
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of F2R mRNA18654764
C018021cobaltous chloridecobaltous chloride results in decreased expression of F2R mRNA19320972
D005576Colforsin[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]22207716
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of F2R mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of F2R mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of F2R mRNA19167446
D003471CuprizoneCuprizone results in increased expression of F2R mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D016572CyclosporineCyclosporine results in decreased expression of F2R mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of F2R mRNA19770486
C515055darinaparsindarinaparsin results in increased expression of F2R mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of F2R mRNA]22535156
C014347decitabinedecitabine results in increased expression of F2R mRNA16367923
D003907DexamethasoneDexamethasone results in increased expression of F2R protein11733402
D003907DexamethasoneDexamethasone affects the expression of F2R protein19969022
D003907DexamethasoneDexamethasone results in increased expression of F2R mRNA11733402
D003907DexamethasoneDexamethasone results in increased expression of F2R protein11733402
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of F2R mRNA]11733402
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of F2R mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of F2R mRNA15620428|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of F2R mRNA21266533
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of F2R mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of F2R mRNA26546572
D004041Dietary FatsDietary Fats results in increased expression of F2R mRNA18042831|2260994
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of F2R mRNA15620428
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of F2R mRNA25380136
D004237DiuronDiuron results in increased expression of F2R mRNA21551480
C067311docetaxelF2R protein results in decreased susceptibility to docetaxel16052512
C540445E 5555E 5555 binds to and results in decreased activity of F2R protein19814731
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of F2R mRNA12655031
D000431EthanolEthanol results in increased expression of F2R mRNA17920746
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of F2R mRNA23649840
C044815etonogestreletonogestrel results in increased expression of F2R mRNA11733402
C044815etonogestrelMifepristone inhibits the reaction [etonogestrel results in increased expression of F2R mRNA]11733402
D005047EtoposideF2R protein affects the susceptibility to Etoposide16217747
C540355fenamidonefenamidone results in increased expression of F2R mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of F2R gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of F2R mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of F2R mRNA19167457
C070081fulvestrantfulvestrant results in increased expression of F2R mRNA12154049
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D005839GentamicinsGentamicins results in increased expression of F2R mRNA22061828
C033273GestodeneGestodene results in increased expression of F2R mRNA11733402
C401858GW 7604GW 7604 results in increased expression of F2R mRNA12154049
C010176halofuginonehalofuginone results in increased expression of F2R mRNA17180598
D006493HeparinHeparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]19468011
D017313FenretinideFenretinide results in increased expression of F2R mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of F2R mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of F2R mRNA12419474
C492448ICG 001ICG 001 results in increased expression of F2R mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of F2R mRNA25613284
C008261lead acetatelead acetate results in decreased expression of F2R mRNA22613225
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of F2R mRNA18654764
C467567lenalidomidelenalidomide results in decreased expression of F2R mRNA15618473
C467567lenalidomidelenalidomide results in decreased expression of F2R protein15618473
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of F2R mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of F2R protein"12598324
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of F2R protein11733402
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of F2R mRNA11733402
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of F2R protein11733402
D017258Medroxyprogesterone AcetateMifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of F2R mRNA]11733402
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of F2R gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of F2R mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of F2R mRNA29191790
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of F2R mRNA]11733402
D015735MifepristoneMifepristone inhibits the reaction [etonogestrel results in increased expression of F2R mRNA]11733402
D015735MifepristoneMifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of F2R mRNA]11733402
D016685MitomycinF2R protein affects the susceptibility to Mitomycin16217747
C415424N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine"[N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] promotes the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]"22207716
C415424N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine"[N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] which results in increased chemical synthesis of Progesterone"22207716
C415424N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine"N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein"22207716
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of F2R mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of F2R mRNA"25554681
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]21037076
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of F2R mRNA21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCL2 mRNA]21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA]21037076
D0150581-NaphthylisothiocyanateF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]21037076
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of F2R mRNA25380136
D009525NiacinNiacin results in increased expression of F2R protein20539903
C028007nickel monoxidenickel monoxide results in decreased expression of F2R mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of F2R mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of F2R mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of F2R mRNA25729387
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of F2R mRNA]22535156
D010100OxygenOxygen deficiency results in increased expression of F2R mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D000073878Palm OilPalm Oil results in increased expression of F2R mRNA18042831
C462999PAR-1-activating peptidePAR-1-activating peptide binds to and results in increased activity of F2R protein15037813
D052638Particulate MatterParticulate Matter results in increased expression of F2R mRNA22369193|2476925
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of F2R mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of F2R mRNA19095052
D010416PentachlorophenolPentachlorophenol results in decreased expression of F2R mRNA23892564
D010455PeptidesPeptides results in increased activity of F2R protein15086339
D010455Peptides[Peptides results in increased activity of F2R protein] which results in increased abundance of Calcium15086339
D010455Peptides[Peptides results in increased activity of F2R protein] which results in increased expression of CXCL1 mRNA15086339
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of F2R mRNA20136073
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of F2R mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of F2R mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of F2R mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of F2R mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of F2R mRNA]17950772
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
D010936Plant ExtractsPlant Extracts results in increased expression of F2R mRNA23557933
D011374Progesterone[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]22207716
D011374Progesterone"[N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] promotes the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]"22207716
D011374Progesterone"[N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] which results in increased chemical synthesis of Progesterone"22207716
D011374ProgesteroneProgesterone affects the expression of F2R mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of F2R mRNA11733402|2177076
C005556propionaldehydepropionaldehyde results in increased expression of F2R mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of F2R mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of F2R mRNA27029645
D011794QuercetinQuercetin results in increased expression of F2R mRNA21632981
C037219quinolinequinoline analog binds to and results in decreased activity of F2R protein16380251
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of F2R mRNA12154049
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]23452621
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of F2R mRNA21427059
C410733scriptaidscriptaid affects the expression of F2R mRNA18813790
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of F2R mRNA19244175
D012643SeleniumSelenium results in decreased expression of F2R mRNA19244175
C515806seryl-arginyl-leucyl-leucyl-argininamideseryl-arginyl-leucyl-leucyl-argininamide results in increased activity of F2R protein15037813
D012715Sesame OilSesame Oil results in increased expression of F2R mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of F2R mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of F2R mRNA12760830
D012969Sodium FluorideSodium Fluoride results in increased expression of F2R mRNA27862939
D016559TacrolimusTacrolimus results in decreased expression of F2R mRNA25270620
D013629TamoxifenESR1 protein affects the reaction [Tamoxifen results in decreased expression of F2R mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of F2R mRNA14699072
D013739TestosteroneTestosterone results in increased expression of F2R mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of F2R mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of F2R mRNA12377990
D013749TetrachlorodibenzodioxinF2R affects the susceptibility to Tetrachlorodibenzodioxin27613713
D013749TetrachlorodibenzodioxinF2R gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IL6 protein]27613713
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of F2R mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of F2R mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of F2R mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of F2R mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of F2R mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of F2R mRNA15618473
D013792ThalidomideThalidomide results in decreased expression of F2R protein15618473
D013917ThrombinThrombin binds to and results in increased activity of [F2R protein binds to F2RL3 protein]16505172
C009495titanium dioxidetitanium dioxide results in decreased expression of F2R mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of F2R mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of F2R mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of F2R mRNA25729387
D019772TopotecanTopotecan results in increased expression of F2R mRNA25729387
D014212TretinoinTretinoin results in increased expression of F2R mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of F2R mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of F2R mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of F2R mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of F2R mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of F2R mRNA24935251|2718838
D014635Valproic AcidValproic Acid analog results in decreased expression of F2R mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of F2R mRNA20546886|2142705
D014638VanadatesVanadates results in increased expression of F2R mRNA22714537
D014640VancomycinVancomycin results in decreased expression of F2R mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased expression of F2R mRNA22369193
C025643vinclozolinvinclozolin results in increased expression of F2R mRNA22570695
D002762CholecalciferolCholecalciferol results in increased expression of F2R mRNA17170073
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of F2R mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of F2R mRNA19244175
C530299vorapaxarvorapaxar binds to and results in decreased activity of F2R protein19814731

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-ISS-  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-ISS-  
GO:0004930G-protein coupled receptor activity-TAS17848177  
GO:0005102signaling receptor binding-IPI1672265  
GO:0005515protein binding-IPI17299037  17848177  20164183  20826780  22547407  24732013  
GO:0015057thrombin-activated receptor activity-IBA21873635  
GO:0015057thrombin-activated receptor activity-IDA1672265  10692450  
GO:0031681G-protein beta-subunit binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-ISS-  
GO:0002248connective tissue replacement involved in inflammatory response wound healing-IDA9639571  
GO:0003105negative regulation of glomerular filtration-ISS-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA10692450  
GO:0006954inflammatory response-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IDA20164183  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007529establishment of synaptic specificity at neuromuscular junction-ISS-  
GO:0007596blood coagulation-TAS-  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0008285negative regulation of cell proliferation-IDA10692450  
GO:0009611response to wounding-IDA9639571  
GO:0009653anatomical structure morphogenesis-TAS9701242  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0030168platelet activation-IDA9038223  
GO:0030168platelet activation-TAS-  
GO:0030193regulation of blood coagulation-IDA17848177  
GO:0030194positive regulation of blood coagulation-IDA9038223  
GO:0030335positive regulation of cell migration-IMP9701242  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0032651regulation of interleukin-1 beta production-ISS-  
GO:0032967positive regulation of collagen biosynthetic process-IDA9639571  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0035025positive regulation of Rho protein signal transduction-ISS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA10692450  
GO:0043410positive regulation of MAPK cascade-IDA17848177  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043547positive regulation of GTPase activity-IMP23202369  
GO:0045217cell-cell junction maintenance-IMP23202369  
GO:0045893positive regulation of transcription, DNA-templated-IDA17848177  
GO:0045907positive regulation of vasoconstriction-ISS-  
GO:0045987positive regulation of smooth muscle contraction-ISS-  
GO:0046427positive regulation of JAK-STAT cascade-NAS10692450  
GO:0048873homeostasis of number of cells within a tissue-ISS-  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA1672265  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-ISS-  
GO:0051928positive regulation of calcium ion transport-ISS-  
GO:0051930regulation of sensory perception of pain-ISS-  
GO:0060155platelet dense granule organization-IC1672265  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070493thrombin-activated receptor signaling pathway-IEA-  
GO:0099553trans-synaptic signaling by endocannabinoid, modulating synaptic transmission-IEA-  
GO:1900134negative regulation of renin secretion into blood stream-ISS-  
GO:2000484positive regulation of interleukin-8 secretion-IDA17404307  
GO:2000778positive regulation of interleukin-6 secretion-IDA11447194  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005769early endosome-IDA22547407  24732013  
GO:0005770late endosome-IDA24732013  
GO:0005794Golgi apparatus-TAS7961693  
GO:0005886plasma membrane-IDA9038223  22547407  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1672265  
GO:0005901caveola-IDA17848177  
GO:0009986cell surface-IDA24732013  
GO:0031094platelet dense tubular network-IDA9038223  
GO:0031594neuromuscular junction-ISS-  
GO:0045211postsynaptic membrane-ISS-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04144Endocytosis
hsa04610Complement and coagulation cascades
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109582HemostasisIEA
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)IEA
R-HSA-500792GPCR ligand bindingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26446588Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention. (2016 May)Friedman EAJ Thromb Thrombolysis