Gene info: ID 2152

Gene: F3

GENE ID: 2152

Synonyms: CD142|TF|TFA

Description: coagulation factor III, tissue factor

Gene type: protein-coding

Location: 1p21.3

dbXrefs: Ensembl:ENSG00000117525 MIM:134390 Vega:OTTHUMG00000010716 UniprotKB:P13726

RefSeq: NG_029366.1

Retrived from: PubMed|SNP Mapped

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.612e-1 (AD) 3.939e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RFX4	0.918
LRIG1	0.906
FGF2	0.892
RHPN2	0.88
CNN3	0.877
NEK6	0.875
SDC2	0.859
SH3BP2	0.853
ATP1B2	0.847
RAB34	0.844

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CALHM1	-0.449
CNTN6	-0.438
CACNA1F	-0.435
AGMAT	-0.434
ABCC12	-0.422
TYRP1	-0.409
SAMD5	-0.406
ADTRP	-0.405
SLC7A4	-0.403
DRD5	-0.4

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00036	Coagulation factor VIIa Recombinant Human	BiotechDrug	102786-61-8	Approved	Target
DB07207	2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE	Small Molecule		Experimental	Target
DB07247	[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA	Small Molecule		Experimental	Target
DB08232	[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid	Small Molecule		Experimental	Target
DB13150	Coagulation factor VII human	BiotechDrug		Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C432747	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [IL1B protein results in increased expression of F3 protein]"	27556861
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of F3 mRNA"	26377693
C553294	1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one	"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in increased expression of F3 protein"	25569083
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of F3 mRNA	28329830
C032668	1-nitropyrene	1-nitropyrene results in increased expression of F3 mRNA	19041380
C024336	1-phenylazo-2-naphthol	1-phenylazo-2-naphthol results in increased expression of F3 protein	25569083
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3]	16009787
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]	15020266
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of F3 mRNA]	20118172
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of F3 mRNA"	19114083
C540167	2-(4-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethan-1-ol	"2-(4-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethan-1-ol results in increased expression of F3 protein"	25569083
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]	15020266
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]	16009787
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide results in increased expression of F3 protein	25569083
C524063	2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one	"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein]"	18325115
C099630	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine	"3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]"	20118172
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of F3 mRNA"	23196670
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of F3 mRNA	16788091
C517623	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
C517623	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
C517623	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
C517623	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al	MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
C517623	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al	PPARA protein affects the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of F3 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
C509621	4-amino-7-phenylpyrazol(3,4-d)pyrimidine	"4-amino-7-phenylpyrazol(3,4-d)pyrimidine results in increased expression of F3 protein"	25569083
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of F3 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
C558529	9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one	"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one results in increased expression of F3 protein"	25569083
C089740	abiraterone	abiraterone results in increased expression of F3 protein	25569083
D000082	Acetaminophen	Acetaminophen results in increased expression of F3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of F3 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of F3 protein	27720869
D000082	Acetaminophen	caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]	27720869
D000082	Acetaminophen	F3 protein results in increased susceptibility to Acetaminophen	17654741
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of F3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of F3 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of F3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of F3 mRNA	19770486
D000393	Air Pollutants	Air Pollutants results in increased expression of F3 mRNA	24752501
D000393	Air Pollutants	diphenyleneiodonium inhibits the reaction [Air Pollutants results in increased expression of F3 mRNA]	24752501
D000393	Air Pollutants	NOX4 protein promotes the reaction [Air Pollutants results in increased expression of F3 mRNA]	24752501
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of F3 mRNA"	23195993
C103505	AM 251	[AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]	27556861
C103505	AM 251	[AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
D000638	Amiodarone	Amiodarone inhibits the reaction [F2 protein results in increased expression of and results in increased activity of F3 protein]	18974383
D000638	Amiodarone	Amiodarone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of F3 protein]	18974383
D000638	Amiodarone	Amiodarone results in decreased activity of F3 protein	18974383
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of F3 mRNA	16483693
D000661	Amphetamine	"3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]"	20118172
D000661	Amphetamine	Amphetamine promotes the reaction [F2 protein results in increased expression of F3 protein]	20118172
D000661	Amphetamine	Amphetamine promotes the reaction [TNF protein results in increased activity of F3 protein]	20118172
D000661	Amphetamine	Amphetamine promotes the reaction [TNF protein results in increased expression of F3 mRNA]	20118172
D000661	Amphetamine	Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]	20118172
D000661	Amphetamine	Amphetamine results in increased activity of F3 protein	20118172
D000661	Amphetamine	Amphetamine results in increased expression of F3 protein	20118172
D000661	Amphetamine	L 750667 inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]	20118172
C078814	anandamide	anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C078814	anandamide	anandamide results in increased expression of F3 protein	27556861
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of F3 protein	27556861
D001151	Arsenic	Arsenic affects the expression of F3 protein	24675094
D001151	Arsenic	Arsenic affects the methylation of F3 gene	25304211
C006632	arsenic trioxide	arsenic trioxide affects the expression of F3 protein	11798557\|1461957
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Tretinoin results in decreased expression of F3 mRNA]	10803529
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Tretinoin results in decreased expression of F3 protein]	10803529
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of and results in decreased activity of F3 protein	10803529
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of F3 mRNA	10400422\|1080352
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of F3 protein	10400422\|1172140
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of F3 mRNA	11189487
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of F3 protein	11189487
D001194	Asbestos	Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]	15636197
D017638	Asbestos, Crocidolite	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased activity of F3 protein"	15636197
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of F3 mRNA"	15371228\|1563619
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of F3 protein"	15371228
D017638	Asbestos, Crocidolite	"calphostin complex inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D017638	Asbestos, Crocidolite	"Lithium Chloride inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D017638	Asbestos, Crocidolite	"SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D017638	Asbestos, Crocidolite	"Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D017638	Asbestos, Crocidolite	"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D001554	Benzene	Benzene affects the expression of F3 mRNA	21147609
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of F3 protein	25569083
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of F3 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F3 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of F3 mRNA	19770486\|2373587
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F3 mRNA	22610609\|2373587
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of F3 mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of F3 mRNA	20106945
D004958	Estradiol	Estradiol affects the expression of F3 mRNA	15598610
D004958	Estradiol	[Estradiol co-treated with Tamoxifen] results in decreased expression of F3 mRNA	17823450
D004958	Estradiol	Estradiol affects the expression of F3 mRNA	15964915
D004958	Estradiol	Estradiol affects the expression of F3 protein	15964915
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of F3 mRNA	18192240
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in decreased expression of F3 mRNA	15912405
C006780	bisphenol A	bisphenol A results in decreased expression of F3 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of F3 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of F3 protein	23696885
D000069286	Bortezomib	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA	23696885
D000069286	Bortezomib	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein	23696885
C046785	bryostatin 1	bryostatin 1 results in increased expression of F3 protein	25569083
C054557	bryostatin 2	bryostatin 2 results in increased expression of F3 protein	25569083
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
C584509	C646 compound	C646 compound results in increased expression of F3 mRNA	26191083
C040048	caffeic acid	caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]	27720869
C061465	calphostin complex	"calphostin complex inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
C061465	calphostin complex	calphostin complex results in decreased expression of F3 mRNA	15371228
C117446	cangrelor	cangrelor results in decreased expression of and results in decreased activity of F3 protein	20200314
C117446	cangrelor	Indomethacin promotes the reaction [cangrelor results in decreased expression of and results in decreased activity of F3 protein]	20200314
D002185	Cannabidiol	Cannabidiol results in increased expression of F3 protein	27556861
C071423	capsazepine	capsazepine promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
C005563	captax	captax results in increased expression of F3 protein	25569083
D002251	Carbon Tetrachloride	PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of F3 mRNA]	18038451
D002330	Carmustine	Carmustine results in increased expression of F3 mRNA	16005536
C043211	carvedilol	[irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA	21229253
C043211	carvedilol	[irbesartan co-treated with carvedilol] results in decreased expression of F3 protein	21229253
C100187	chloropicrin	chloropicrin results in decreased expression of F3 mRNA	26352163\|2847649
D002737	Chloroprene	Chloroprene results in increased expression of F3 mRNA	23125180
C023676	chloroquine diphosphate	chloroquine diphosphate results in increased expression of F3 protein	25569083
D002744	Chlorpheniramine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]	16009787
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased activity of F3 protein"	16971767
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of F3 mRNA"	16971767
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of F3 protein]"	16971767
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of F3 mRNA]"	16971767
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of F3 mRNA	28472532
D002996	Clomiphene	Clomiphene results in increased expression of F3 protein	25569083
C018021	cobaltous chloride	cobaltous chloride results in increased expression of F3 protein	25569083
D003078	Colchicine	Colchicine results in increased expression of F3 mRNA	20624997
C036978	concanamycin A	concanamycin A results in increased expression of F3 protein	25569083
D003300	Copper	Copper results in increased expression of F3 mRNA	24403277
D003300	Copper	Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D003300	Copper	Copper results in increased expression of and results in increased activity of F3 protein	7600656
D003300	Copper	Copper results in increased expression of F3 mRNA	7600656
D003300	Copper	Probucol inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D003300	Copper	U 74389F inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D003300	Copper	Vitamin E inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D003300	Copper	Copper results in increased expression of F3 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of F3 mRNA	19549813
C551994	crizotinib	crizotinib results in increased expression of F3 protein	25569083
D003471	Cuprizone	Cuprizone results in increased expression of F3 mRNA	26577399
D003474	Curcumin	Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]	18983524
D003474	Curcumin	Curcumin results in decreased expression of F3	18462866
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tretinoin results in decreased expression of F3 mRNA]	11876987
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of F3 mRNA	17403535
D015638	Cytochalasin D	Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	25858758
D003630	Daunorubicin	Daunorubicin results in increased expression of F3 mRNA	11721405
D003630	Daunorubicin	Daunorubicin results in increased expression of F3 protein	11721405
D003676	Deferoxamine	Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]	25858758
C121345	desloratadine	desloratadine results in increased expression of F3 protein	25569083
D003907	Dexamethasone	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA	23696885
D003907	Dexamethasone	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein	23696885
D003907	Dexamethasone	[Dexamethasone co-treated with lenalidomide] results in increased expression of F3 mRNA	23696885
D003907	Dexamethasone	[Dexamethasone co-treated with lenalidomide] results in increased expression of F3 protein	23696885
D003907	Dexamethasone	Dexamethasone promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D003907	Dexamethasone	Dexamethasone results in increased expression of F3 mRNA	23696885\|2504701
D003907	Dexamethasone	Dexamethasone results in increased expression of F3 protein	23696885
D003907	Dexamethasone	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of F3 mRNA]	21731756
D003907	Dexamethasone	Dexamethasone promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
C007287	dexon (fungicide), sodium salt	"dexon (fungicide), sodium salt results in increased expression of F3 protein"	25569083
D003976	Diazinon	Diazinon results in increased methylation of F3 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of F3 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of F3 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of F3 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of F3 mRNA	22023808
D004041	Dietary Fats	Dietary Fats results in decreased expression of F3 mRNA	18042831
D004155	Diphenhydramine	Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]	16009787
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Air Pollutants results in increased expression of F3 mRNA]	24752501
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	24752501
D004229	Dithiothreitol	Dithiothreitol results in increased activity of F3 protein	17726162
D004237	Diuron	Diuron results in decreased expression of F3 mRNA	21551480\|2515243
D004280	Dobutamine	Dobutamine results in increased expression of F3 protein	16286589
C041588	dodecylbenzene	dodecylbenzene results in increased expression of F3 protein	25569083
D004298	Dopamine	Dopamine promotes the reaction [TNF protein results in increased expression of F3 mRNA]	20118172
D004317	Doxorubicin	[F3 protein affects the expression of BCL2 protein] which affects the susceptibility to Doxorubicin	18325115
D004317	Doxorubicin	F3 protein affects the reaction [Doxorubicin affects the cleavage of and affects the activity of CASP3 protein]	18278454
D004317	Doxorubicin	F3 protein affects the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]	18246814
D004317	Doxorubicin	[[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein] which results in decreased susceptibility to Doxorubicin	18325115
D004656	Enalapril	Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]	18060435
D004656	Enalapril	Enalapril results in decreased expression of F3 protein	22188725
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased activity of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased expression of F3 mRNA]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased expression of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) affects the expression of F3 mRNA"	15964915
D000431	Ethanol	Ethanol results in increased expression of F3 protein	25569083
D000431	Ethanol	Ethanol results in increased expression of F3 protein	24065054
D005033	Ethylmaleimide	Ethylmaleimide results in increased expression of F3 protein	25569083
C044815	etonogestrel	etonogestrel promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D005047	Etoposide	Etoposide results in increased expression of F3 mRNA	12542493
D000068338	Everolimus	Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein]	19567381
C540355	fenamidone	fenamidone results in increased expression of F3 mRNA	27029645
C013531	ferric ammonium citrate	Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]	25858758
C013531	ferric ammonium citrate	ferric ammonium citrate results in increased expression of F3 mRNA	25858758
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of F3 mRNA	28329830
D005472	Fluorouracil	F3 affects the susceptibility to Fluorouracil	15067352
D005472	Fluorouracil	Fluorouracil results in decreased expression of F3 mRNA	16510598
C096856	FTI 277	FTI 277 results in decreased expression of F3 mRNA	18192240
C039281	furan	furan results in increased expression of F3 mRNA	27387713
C017338	geranylgeraniol	geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]	12753293
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]	18031796
C102521	GGTI 298	GGTI 298 results in decreased expression of F3 mRNA	18192240
D005978	Glutathione	Glutathione results in increased activity of F3 protein	17726162
D006418	Heme	Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]	18983524
D006418	Heme	Heme results in increased expression of and results in increased activity of F3 protein	18983524
D006418	Heme	Heme results in increased expression of F3 mRNA	18983524
D006418	Heme	Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]	18983524
D006632	Histamine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	[Histamine co-treated with splitomicin] results in increased expression of F3 protein	20978007
D006632	Histamine	Histamine results in increased activity of F3 protein	16009787
D006632	Histamine	Histamine results in increased expression of F3 mRNA	16009787
D006632	Histamine	Histamine results in increased expression of F3 protein	16009787\|2556908
D006632	Histamine	pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]	16009787
D006632	Histamine	Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	SB 203580 inhibits the reaction [Histamine results in increased expression of F3]	16009787
D006632	Histamine	wortmannin promotes the reaction [Histamine results in increased expression of F3]	16009787
C027556	histamine phosphate	histamine phosphate results in increased expression of F3 protein	25569083
D007052	Ibuprofen	Ibuprofen results in increased expression of F3 mRNA	17070997
C492448	ICG 001	ICG 001 results in increased expression of F3 mRNA	26191083
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of F3 protein	25569083
D007213	Indomethacin	Indomethacin promotes the reaction [cangrelor results in decreased expression of and results in decreased activity of F3 protein]	20200314
D007213	Indomethacin	Indomethacin results in decreased expression of and results in decreased activity of F3 protein	20200314
C094023	iodopravadoline	[AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]	27556861
C094023	iodopravadoline	[AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
C094023	iodopravadoline	iodopravadoline promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]	27556861
C094023	iodopravadoline	iodopravadoline promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of F3 mRNA	25613284
C081309	irbesartan	[irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA	21229253
C081309	irbesartan	[irbesartan co-treated with carvedilol] results in decreased expression of F3 protein	21229253
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of F3 mRNA	24796395
D007654	Ketoconazole	Ketoconazole results in increased expression of F3 protein	25569083
C103081	L 750667	L 750667 inhibits the reaction [Amphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]]	20118172
C467567	lenalidomide	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA	23696885
C467567	lenalidomide	[Dexamethasone co-treated with lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein	23696885
C467567	lenalidomide	[Dexamethasone co-treated with lenalidomide] results in increased expression of F3 mRNA	23696885
C467567	lenalidomide	[Dexamethasone co-treated with lenalidomide] results in increased expression of F3 protein	23696885
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of F3 protein"	7600656\|9974427
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of F3 mRNA"	7600656\|9974427
C440499	lipopolysaccharide, Escherichia coli O111 B4	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of F3 protein]"	9974427
C440499	lipopolysaccharide, Escherichia coli O111 B4	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of F3 mRNA]"	9974427
D008070	Lipopolysaccharides	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
D008070	Lipopolysaccharides	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
D008070	Lipopolysaccharides	3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of F3 protein	17141290\|1828962
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of F3	11858183
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of F3 mRNA	17141290\|1828962
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of F3 protein	15824212\|1714129
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of F3 protein	17513194
D008070	Lipopolysaccharides	MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
D008070	Lipopolysaccharides	MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	9102164
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	9102164
D008070	Lipopolysaccharides	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	18289624
D008070	Lipopolysaccharides	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	18289624
D008070	Lipopolysaccharides	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	18289624
D008070	Lipopolysaccharides	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
D008070	Lipopolysaccharides	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
D008070	Lipopolysaccharides	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
D008070	Lipopolysaccharides	PPARA protein affects the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
D008070	Lipopolysaccharides	PPARA protein affects the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
D008070	Lipopolysaccharides	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
D008070	Lipopolysaccharides	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
D008070	Lipopolysaccharides	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
D008070	Lipopolysaccharides	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	12871381
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	12871381
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of F3]	11858183
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	15824212
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of F3 mRNA]	21731756
D008070	Lipopolysaccharides	[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of F3 mRNA	21731756
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of F3 mRNA	25613284
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of F3 mRNA	16415329
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of F3 mRNA	12473561
D008070	Lipopolysaccharides	nitroaspirin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	12473561
D008070	Lipopolysaccharides	nitroaspirin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	12473561
D008070	Lipopolysaccharides	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA]	16415329
D018021	Lithium Chloride	"Lithium Chloride inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of F3 mRNA	15371228
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]	18060435
D019808	Losartan	Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]	18060435
D019808	Losartan	Losartan results in decreased expression of F3 mRNA	22188725
D019808	Losartan	Losartan results in decreased expression of F3 protein	22188725
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of F3 mRNA	26378955
C013099	mancozeb	mancozeb results in increased expression of F3 protein	25569083
C057383	MDL 201053	MDL 201053 results in increased expression of F3 protein	25569083
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of F3 protein	16011840
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
C042720	mercuric bromide	mercuric bromide results in increased expression of F3 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
D008627	Mercuric Chloride	ANXA5 protein inhibits the reaction [Mercuric Chloride results in increased activity of F3 protein]	17726162
D008627	Mercuric Chloride	Mercuric Chloride results in increased activity of F3 protein	17726162
D008694	Methamphetamine	Methamphetamine results in increased methylation of F3 promoter	26307267
C088155	methanandamide	[AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
C088155	methanandamide	capsazepine promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
C088155	methanandamide	iodopravadoline promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]	27556861
C088155	methanandamide	methanandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C088155	methanandamide	methanandamide results in increased expression of F3 protein	27556861
D008727	Methotrexate	Methotrexate results in increased expression of F3 mRNA	12542493
D008727	Methotrexate	Methotrexate results in increased expression of F3 mRNA	16005536
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of F3 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [TNF protein results in increased activity of F3 protein]"	20118172
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [TNF protein results in increased expression of F3 protein]"	20118172
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of F3 protein"	20118172
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of F3 protein"	20118172
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of F3 mRNA	17412507
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]	12753293
C037144	mifamurtide	mifamurtide results in increased expression of F3 protein	25569083
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased expression of F3 protein]	15562024
D015735	Mifepristone	Mifepristone results in increased expression of F3 mRNA	19439560
D015735	Mifepristone	Mifepristone results in decreased expression of F3 mRNA	25972201
C548887	MK 2206	MK 2206 results in increased expression of F3 protein	25569083
C060893	MK-886	MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
C060893	MK-886	MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
D000068656	Mometasone Furoate	Mometasone Furoate results in increased expression of F3 protein	25569083
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of F3 mRNA	16809437
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of F3 mRNA	19162170
C440780	mono-N-desethylamiodarone	mono-N-desethylamiodarone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of F3 protein]	18974383
D009151	Mustard Gas	Mustard Gas results in decreased expression of F3 mRNA	18955075
C064769	N-acetylsphingosine	N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C064769	N-acetylsphingosine	N-acetylsphingosine results in increased expression of F3 protein	27556861
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of F3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of F3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of F3 mRNA"	25620056
C031721	naphthalene	naphthalene results in increased expression of F3 mRNA	18978301
D015058	1-Naphthylisothiocyanate	F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]	21037076
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased activity of F3 protein	21070799
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of F3 mRNA	21037076
D015058	1-Naphthylisothiocyanate	F3 mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]	21070799
D015058	1-Naphthylisothiocyanate	F3 mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of F2 protein]	21070799
D015058	1-Naphthylisothiocyanate	F3 protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of F2 protein]	21070799
D015058	1-Naphthylisothiocyanate	F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCL2 mRNA]	21037076
D015058	1-Naphthylisothiocyanate	F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]	21037076
D015058	1-Naphthylisothiocyanate	F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA]	21037076
D015058	1-Naphthylisothiocyanate	F3 protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]	21037076
D015058	1-Naphthylisothiocyanate	F3 protein results in increased susceptibility to 1-Naphthylisothiocyanate	21070799
D009532	Nickel	Nickel results in increased expression of F3 mRNA	23195993
C029938	nickel sulfate	nickel sulfate results in decreased expression of F3 mRNA	22714537
C029938	nickel sulfate	nickel sulfate results in increased expression of F3 mRNA	16100012
D009538	Nicotine	Nicotine results in increased expression of F3 mRNA	17997037
C012655	nimesulide	nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased expression of F3 mRNA]	25339356
C102148	nitroaspirin	nitroaspirin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	12473561
C102148	nitroaspirin	nitroaspirin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	12473561
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of F3 mRNA	17616710
D009638	Norepinephrine	Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D009638	Norepinephrine	Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D009638	Norepinephrine	Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]	23114885
D009638	Norepinephrine	Norepinephrine promotes the reaction [REL protein binds to F3 promoter]	23114885
D009638	Norepinephrine	Norepinephrine results in increased expression of F3 mRNA	23114885
D009638	Norepinephrine	prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D009638	Norepinephrine	RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D009638	Norepinephrine	REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D009638	Norepinephrine	Vitamin E inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	9102164
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	9102164
C570897	NSC668394	NSC668394 results in increased expression of F3 mRNA	27137931
C025589	ochratoxin A	ochratoxin A inhibits the reaction [IL1B protein results in increased expression of F3 protein]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of F3 protein]	18289624
C025589	ochratoxin A	ochratoxin A inhibits the reaction [TNF protein results in increased expression of F3 protein]	18289624
C025589	ochratoxin A	ochratoxin A results in increased expression of F3 mRNA	12700408\|2335814
C030110	oxaliplatin	oxaliplatin results in decreased expression of F3 mRNA	16510598
D010126	Ozone	Ozone results in increased activity of F3 protein	18381685
D010126	Ozone	Ozone results in increased expression of F3 mRNA	17095637\|1838168
D010126	Ozone	[Ozone co-treated with Vehicle Emissions] results in increased expression of F3 mRNA	20980218
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein	19944065
D017239	Paclitaxel	pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
C500026	palbociclib	palbociclib results in increased expression of F3 mRNA	22869556
D000073878	Palm Oil	Palm Oil results in decreased expression of F3 mRNA	18042831
C016030	pantogab	pantogab results in decreased expression of F3 mRNA	17379144
D052638	Particulate Matter	Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	25858758
D052638	Particulate Matter	diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	24752501
D052638	Particulate Matter	F3 protein affects the reaction [Particulate Matter results in increased secretion of CXCL8 protein]	17450221
D052638	Particulate Matter	F3 protein affects the reaction [Particulate Matter results in increased secretion of IL6 protein]	17450221
D052638	Particulate Matter	NOX4 protein promotes the reaction [Particulate Matter results in increased expression of F3 mRNA]	24752501
D052638	Particulate Matter	Particulate Matter analog results in increased expression of F3 mRNA	17450221
D052638	Particulate Matter	Particulate Matter results in increased expression of F3 mRNA	17450221\|2030732
D052638	Particulate Matter	Particulate Matter results in increased expression of F3 protein	17450221\|2585875
D052638	Particulate Matter	U 0126 inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	25858758
D052638	Particulate Matter	Particulate Matter results in increased expression of F3 mRNA	21708214
D052638	Particulate Matter	Particulate Matter results in increased expression of F3 mRNA	25858758
D052638	Particulate Matter	Particulate Matter results in increased expression of F3 protein	25858758
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of F3 mRNA	26678675
D010634	Phenobarbital	Phenobarbital affects the expression of F3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the activity of F3 protein	19952496
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of F3 mRNA	26272509
C008876	phorbol-12,13-didecanoate	"phorbol-12,13-didecanoate results in increased expression of F3 protein"	25569083
D010705	Phosgene	Phosgene affects the expression of F3 mRNA	16300373
C572555	picolog	picolog results in increased expression of F3 protein	25569083
C006253	pirinixic acid	MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
C006253	pirinixic acid	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
C006253	pirinixic acid	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
C006253	pirinixic acid	pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]	17141290
C006253	pirinixic acid	pirinixic acid results in increased expression of F3 mRNA	18301758\|2381119
D008926	Plicamycin	Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]	15636197
D008926	Plicamycin	Plicamycin results in decreased expression of F3 mRNA	15636197
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of F3 mRNA	27989595
D011319	Primaquine	Primaquine results in increased expression of F3 protein	25569083
D011324	Primidone	Primidone results in increased expression of F3 protein	25569083
D011341	Probucol	Probucol inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D011374	Progesterone	Progesterone results in increased expression of F3 mRNA	20631399
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of F3 mRNA	20660070
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased expression of F3 protein]	15562024
D011374	Progesterone	Progesterone results in increased expression of F3 mRNA	15562024\|2179573
D011374	Progesterone	Progesterone results in increased expression of F3 protein	15562024
D011374	Progesterone	Progesterone results in increased expression of F3 mRNA	20726854
D011372	Progestins	Progestins results in increased expression of F3	16011840
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of F3 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of F3 mRNA	27029645
D011719	Pyrazines	Pyrazines results in decreased activity of [F3 protein binds to F7 protein]	14967414
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]	16009787
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]	20118172
D011738	Pyrilamine	Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]	16009787
D011738	Pyrilamine	Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]	16009787
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	17141290
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]	17141290
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	17141290
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased activity of F3 protein]	12871381
D011794	Quercetin	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	12871381
D011794	Quercetin	Quercetin inhibits the reaction [TNF protein results in increased activity of F3 protein]	12871381
D011794	Quercetin	Quercetin results in decreased expression of F3 mRNA	12871381
C012526	quercitrin	quercitrin results in increased expression of F3 mRNA	25193878
D015125	Oxyquinoline	Oxyquinoline results in increased expression of F3 protein	25569083
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of F3 protein	15964915
D011899	Ranitidine	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA]	16415329
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased activity of and results in increased expression of F3 protein]	9974427
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased activity of F3 protein]	12871381
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of F3 mRNA]	9974427
C059514	resveratrol	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of F3 protein]"	9974427
C059514	resveratrol	"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of F3 mRNA]"	9974427
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]	12871381
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of F3]	11858183
C059514	resveratrol	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of F3 protein]	9974427
C059514	resveratrol	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of F3 mRNA]	9974427
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased activity of and results in increased expression of F3 protein]	9974427
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased activity of F3 protein]	12871381
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of F3 mRNA]	9974427
C059514	resveratrol	resveratrol results in decreased expression of F3 mRNA	11858183\|1287138
C059514	resveratrol	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 mRNA]	20978007
C059514	resveratrol	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 protein]	20978007
C013672	riddelliine	riddelliine results in decreased expression of F3 mRNA	18047727
C093642	SB 203580	"SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
C093642	SB 203580	SB 203580 inhibits the reaction [Histamine results in increased expression of F3]	16009787
C093642	SB 203580	SB 203580 inhibits the reaction [IL1B protein results in increased expression of F3 protein]	27556861
C093642	SB 203580	SB 203580 inhibits the reaction [TNF protein results in increased expression of F3 mRNA]	20118172
C093642	SB 203580	SB 203580 results in decreased expression of F3 mRNA	15371228
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased activity of F3 protein"	15636197
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of F3 mRNA"	15636197
D022622	Shiga Toxin 1	[AGT protein modified form co-treated with TNF protein co-treated with Shiga Toxin 1] results in increased expression of F3 mRNA	18060435
D022622	Shiga Toxin 1	AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]	18060435
D022622	Shiga Toxin 1	Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]	18060435
D022622	Shiga Toxin 1	Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]	18060435
D022622	Shiga Toxin 1	Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]	18060435
D022622	Shiga Toxin 1	[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein	18060435
D022641	Shiga Toxin 2	Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of F3 mRNA]	21731756
D022641	Shiga Toxin 2	[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of F3 mRNA	21731756
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of F3 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of F3 mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of F3 mRNA	22431001
D012834	Silver	Silver results in increased expression of F3 mRNA	26014281
D019821	Simvastatin	F3 polymorphism affects the susceptibility to Simvastatin	19027114
D019821	Simvastatin	geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]	12753293
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]	18031796
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]	12753293
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]	15824212
D019821	Simvastatin	Simvastatin results in decreased activity of F3 protein	10830219\|1751319
D019821	Simvastatin	Simvastatin results in decreased expression of F3	12753293
D019821	Simvastatin	Simvastatin results in decreased expression of F3 mRNA	10830219\|1751319
D019821	Simvastatin	Simvastatin results in decreased expression of F3 protein	18031796
D019821	Simvastatin	Simvastatin results in increased expression of F3 mRNA	18841289
D019821	Simvastatin	Simvastatin results in increased expression of F3 protein	18841289
D019821	Simvastatin	Simvastatin results in decreased expression of F3 mRNA	12818400
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of F3 protein]"	16971767
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of F3 mRNA]"	16971767
D020123	Sirolimus	Sirolimus promotes the reaction [TNF protein results in increased expression of F3 protein]	19567381
D020123	Sirolimus	Sirolimus results in increased activity of F3 protein	19567381
C439060	sirtinol	sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]	20978007
C439060	sirtinol	sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein]	20978007
D053260	Soot	Soot results in increased expression of F3 mRNA	22461453\|2655175
C444426	splitomicin	[Histamine co-treated with splitomicin] results in increased expression of F3 protein	20978007
C444426	splitomicin	splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]	20978007
C444426	splitomicin	splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]	20978007
C444426	splitomicin	splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]	20978007
C023599	stannous chloride	stannous chloride results in increased expression of F3 protein	25569083
D019311	Staurosporine	"Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of F3 mRNA	26378955
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]	18983524
C061133	tamibarotene	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]	15020266
C061133	tamibarotene	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]	15020266
C061133	tamibarotene	tamibarotene results in decreased expression of F3 mRNA	15020266
D013629	Tamoxifen	Tamoxifen affects the expression of F3 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of F3 mRNA	20937368
D013629	Tamoxifen	[Estradiol co-treated with Tamoxifen] results in decreased expression of F3 mRNA	17823450
C401859	temsirolimus	temsirolimus results in increased expression of F3 protein	25569083
C037815	terconazole	terconazole results in increased expression of F3 protein	25569083
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of F3 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of F3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F3 mRNA	19684285\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of F3 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F3 mRNA	17035482
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of F3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F3 mRNA	15644576
D013755	Tetradecanoylphorbol Acetate	ochratoxin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of F3 protein]	18289624
D013755	Tetradecanoylphorbol Acetate	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of F3 protein]	9974427
D013755	Tetradecanoylphorbol Acetate	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of F3 mRNA]	9974427
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of F3 protein	9974427
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of F3 mRNA	9974427
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of F3 protein	18289624\|2556908
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of F3 mRNA	25613284
D013866	Thioguanine	Thioguanine results in increased expression of F3 mRNA	16005536
C027385	tibolone	tibolone metabolite results in increased expression of F3 protein	16011840
C027385	tibolone	tibolone results in increased expression of F3 protein	16011840
C009495	titanium dioxide	titanium dioxide results in increased expression of F3 protein	22352400
C009495	titanium dioxide	titanium dioxide results in increased expression of F3 mRNA	27760801
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of F3 protein	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of F3 protein]	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of F3 mRNA	28111298
D014118	Toxins, Biological	"Toxins, Biological affects the expression of F3 mRNA"	19682533
D014212	Tretinoin	arsenic trioxide inhibits the reaction [Tretinoin results in decreased expression of F3 mRNA]	10803529
D014212	Tretinoin	arsenic trioxide inhibits the reaction [Tretinoin results in decreased expression of F3 protein]	10803529
D014212	Tretinoin	Cycloheximide inhibits the reaction [Tretinoin results in decreased expression of F3 mRNA]	11876987
D014212	Tretinoin	Tretinoin affects the expression of F3 protein	11798557
D014212	Tretinoin	Tretinoin results in decreased expression of and results in decreased activity of F3 protein	10803529
D014212	Tretinoin	Tretinoin results in decreased expression of F3 mRNA	10400422\|1080352
D014212	Tretinoin	Tretinoin results in decreased expression of F3 protein	10400422\|1172140
D014212	Tretinoin	Tretinoin results in increased expression of F3 mRNA	21934132
D014212	Tretinoin	Tretinoin results in decreased expression of F3	16757074
D014212	Tretinoin	Tretinoin results in decreased expression of F3 mRNA	11189487
D014212	Tretinoin	Tretinoin results in decreased expression of F3 protein	11189487
C012589	trichostatin A	trichostatin A results in increased expression of F3 mRNA	23463510
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of F3 protein"	25569083
C113580	U 0126	"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]"	15371228
C113580	U 0126	U 0126 inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA]	25858758
C113580	U 0126	U 0126 results in decreased expression of F3 mRNA	15371228
C113580	U 0126	U 0126 results in increased expression of F3 protein	25569083
C074854	U 73343	U 73343 results in increased expression of F3 protein	25569083
C074965	U 74389F	U 74389F inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D014635	Valproic Acid	Valproic Acid results in increased expression of F3 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in decreased expression of F3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of F3 mRNA	20307321
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of F3 gene	25560391
D001335	Vehicle Emissions	[Ozone co-treated with Vehicle Emissions] results in increased expression of F3 mRNA	20980218
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of F3 mRNA	20980218
D014747	Vinblastine	Vinblastine results in increased expression of F3 mRNA	20624997
C025643	vinclozolin	vinclozolin affects the expression of F3 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of F3 mRNA	23555832
D014750	Vincristine	Vincristine results in increased expression of F3 mRNA	12542493
D014750	Vincristine	Vincristine results in increased expression of F3 protein	12542493
D014750	Vincristine	Vincristine results in increased expression of F3 mRNA	20624997
C029297	vinylidene chloride	vinylidene chloride results in increased expression of F3 mRNA	26682919
D009536	Niacinamide	Niacinamide results in decreased expression of F3 protein	14627904
D002762	Cholecalciferol	Cholecalciferol results in increased expression of F3 mRNA	17170073
D014810	Vitamin E	Vitamin E inhibits the reaction [Copper results in increased activity of F3 protein]	7600656
D014810	Vitamin E	Vitamin E inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]	23114885
D014810	Vitamin E	Vitamin E results in decreased expression of and results in decreased activity of F3 protein	10216089
C070417	Win 55212-2	Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]	27556861
C070417	Win 55212-2	Win 55212-2 inhibits the reaction [IL1B protein results in increased expression of F3 mRNA]	27556861
C009687	wortmannin	wortmannin promotes the reaction [Histamine results in increased expression of F3]	16009787
C088658	zoledronic acid	zoledronic acid results in decreased expression of F3 mRNA	24714768
C489443	zotarolimus	zotarolimus promotes the reaction [TNF protein results in increased expression of F3 protein]	19567381

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	3455766
GO:0004252	serine-type endopeptidase activity	contributes_to	IDA	24998411
GO:0004896	cytokine receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	8598903 8940045 9414278 15522303 15664864 16959886 20634491 25241761
GO:0005543	phospholipid binding	-	IDA	17469850

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001938	positive regulation of endothelial cell proliferation	-	IDA	17898544
GO:0002541	activation of plasma proteins involved in acute inflammatory response	-	IDA	17469850
GO:0002543	activation of blood coagulation via clotting cascade	-	IC	17469850
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	17898544
GO:0007596	blood coagulation	-	IDA	8632006 24998411
GO:0007598	blood coagulation, extrinsic pathway	-	TAS	-
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	-	IDA	17991872
GO:0016485	protein processing	-	IDA	24998411
GO:0019221	cytokine-mediated signaling pathway	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	TAS	18612547
GO:0045766	positive regulation of angiogenesis	-	IDA	17898544
GO:0050927	positive regulation of positive chemotaxis	-	IC	17991872
GO:0051897	positive regulation of protein kinase B signaling	-	IMP	18612547

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	19065458
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	HDA	19581412
GO:0009986	cell surface	-	IDA	17898544
GO:0016021	integral component of membrane	-	IBA	21873635
GO:0031233	intrinsic component of external side of plasma membrane	-	IC	17469850
GO:0062023	collagen-containing extracellular matrix	-	IDA	2704749
GO:1905286	serine-type peptidase complex	-	IPI	24998411

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28144390	Predictors for advanced fibrosis in morbidly obese non-alcoholic fatty liver patients. (2017 Jan 18)	Zelber-Sagi S	World J Hepatol
15892090	Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. (2005 Jul)	Hezode C	Hepatology
27192695	Increased F3-Isoprostanes in the Canadian Inuit Population Could Be Cardioprotective by Limiting F2-Isoprostane Production. (2016 Sep)	Alkazemi D	J Clin Endocrinol Metab
26733571	Psychological factors and DNA methylation of genes related to immune/inflammatory system markers: the VA Normative Aging Study. (2016 Jan 5)	Kim D	BMJ Open
20360759	Markers of inflammation and weight change in middle-aged adults: results from the prospective MONICA/KORA S3/F3 study. (2010 Dec)	Holz T	Obesity (Silver Spring)
23216352	Cutoff values for alcoholic liver fibrosis using magnetic resonance elastography technique. (2013 May)	Bensamoun SF	Alcohol Clin Exp Res
17334638	Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. (2007 Apr)	Yamaguchi S	Int J Mol Med
22622000	Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. (2012 Sep 1)	Govorko D	Biol Psychiatry
27794398	Case report: Durable response to afatinib in a patient with lung cancer harboring two uncommon mutations of EGFR and a KRAS mutation. (2016 Nov)	Tanizaki J	Lung Cancer
7686471	The effects of ethanol on EEG activity in males at risk for alcoholism. (1993 Jun)	Cohen HL	Electroencephalogr Clin Neurophysiol
27183179	Perinatal nicotine exposure induces myogenic differentiation, but not epithelial-mesenchymal transition in rat offspring lung. (2016 Nov)	Sakurai R	Pediatr Pulmonol
23727505	Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. (2013 Sep 5)	Alvaro-Bartolome M	Neuroscience
8655152	Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men. (1996 May)	Stengard JH	Hum Genet
28898507	Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. (2018 Apr)	Koo BK	Liver Int