Gene: F7

2155
SPCA
coagulation factor VII
protein-coding
13q34
Ensembl:ENSG00000057593 MIM:613878 Vega:OTTHUMG00000017373 UniprotKB:P08709
NG_009262.1
PubMed
0   ANCO-SNPs
ND
3   
2.208e-1 (AD)  7.797e-1 (ND)   (Frontal_Cortex)
5.746e-1 (AD)  6.449e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RELL20.833
MARCH40.826
CHRNB20.825
FBLN70.825
KCNQ40.815
DIRAS10.812
LRTM20.811
ABCG40.811
INPP5J0.811
RASGRF10.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAZ1A-0.607
WWTR1-0.606
CLEC2B-0.605
HEBP2-0.604
TIMP1-0.598
RAB13-0.592
ROM1-0.591
ACTL6A-0.589
YES1-0.586
TGIF1-0.577

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00036Coagulation factor VIIa Recombinant HumanBiotechDrug102786-61-8ApprovedTarget
DB00100Coagulation Factor IX (Recombinant)BiotechDrug181054-95-5Approved|InvestigationalTarget
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalTarget
DB04590(2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACIDSmall MoleculeExperimentalTarget
DB045933-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACIDSmall MoleculeExperimentalTarget
DB046062-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE)Small MoleculeExperimentalTarget
DB047582-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE)Small MoleculeExperimentalTarget
DB04767N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMIDSmall MoleculeExperimentalTarget
DB072072-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINESmall MoleculeExperimentalTarget
DB07247[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREASmall MoleculeExperimentalTarget
DB073765-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)Small MoleculeExperimentalTarget
DB08232[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acidSmall MoleculeExperimentalTarget
DB09332KappadioneSmall Molecule131-13-5ApprovedTarget
DB13151Anti-inhibitor coagulant complexBiotechDrugApproved|InvestigationalTarget
DB13152Coagulation Factor IX HumanBiotechDrug9001-28-9ApprovedTarget
DB13933Nonacog beta pegolBiotechDrug1175512-71-6Approved|InvestigationalTarget
DB13151Anti-inhibitor coagulant complexBiotechDrugApproved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of F7 mRNA"25614096
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein]"18325115
D000082AcetaminophenAcetaminophen affects the expression of F7 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of F7 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of F7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of F7 mRNA19770486
D000447AldehydesAldehydes results in decreased expression of F7 mRNA25014914
D000452AldrinAldrin results in increased expression of F7 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of F7 mRNA16483693
C010680antibiotic G 418antibiotic G 418 results in increased expression of and results in increased activity of F7 protein16706976
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of F7 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of F7 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of F7 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of F7 mRNA22228805
D004958Estradiol[Estradiol co-treated with norethindrone acetate] results in decreased expression of F7 protein17393018
D004958EstradiolEstradiol results in increased expression of F7 mRNA20838740
D001629BezafibrateBezafibrate results in decreased activity of F7 protein11461176
C006780bisphenol Abisphenol A results in decreased expression of F7 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of F7 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of F7 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of F7 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of F7 mRNA18804290
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of F7 protein"15670042
D002994ClofibrateClofibrate results in decreased expression of F7 mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of F7 mRNA17585979|2381119
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F7 mRNA]17585979
C044626CMF protocolCMF protocol results in decreased expression of F79281254
D003276Contraceptives, Oral"Contraceptives, Oral results in increased activity of F7 protein"4180662
D003276Contraceptives, Oral"Contraceptives, Oral results in increased expression of F7 protein"133615
D003276Contraceptives, Oral"Contraceptives, Oral results in increased expression of F7 protein"5700392
C034528CycloProveraCycloProvera results in decreased expression of F7 protein14561536
D016572CyclosporineCyclosporine results in decreased expression of F7 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of F7 mRNA27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of F7 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of F7 mRNA22733784
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein15288212
D004041Dietary FatsDietary Fats results in decreased expression of F7 mRNA25016146
C060340difethialoneF7 protein results in decreased susceptibility to difethialone26860702
C024629dimethyl phthalatedimethyl phthalate affects the expression of F7 mRNA26924002
D004317Doxorubicin[[F3 protein co-treated with F7 protein] results in increased expression of BCL2 protein] which results in decreased susceptibility to Doxorubicin18325115
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester results in decreased activity of F7 protein14614217
C418365estradiol, norethindrone drug combination"estradiol, norethindrone drug combination results in decreased expression of F7 protein"14561536
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of F7 protein15288212
D004967EstrogensEstrogens results in increased activity of and results in increased expression of F7 protein12456630
D004967EstrogensProgestins inhibits the reaction [Estrogens results in increased activity of and results in increased expression of F7 protein]12456630
D004967EstrogensEstrogens results in increased activity of F7 protein11461176
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in increased expression of F7 protein"15850603
D004997Ethinyl Estradiol[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein14561536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of F7 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein12616980|1261825
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of F7 protein15157790
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of F7 protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F7 protein12618251
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of F7 protein8950781
D004997Ethinyl EstradiolF7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein]12616980|1261698
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of F7 mRNA17555576
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of F7 protein12616980|1261825
C442659ethinyl estradiol-desogestrel combinationF7 gene polymorphism affects the reaction [ethinyl estradiol-desogestrel combination results in increased expression of F7 protein]12616980|1261698
D008656MestranolMestranol results in increased expression of F7 protein614942
D011345FenofibrateFenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]9681093
C024555ferric chlorideF7 results in increased susceptibility to ferric chloride12547218
C056933fumonisin B1fumonisin B1 results in decreased expression of F7 mRNA16221962
C039281furanfuran results in decreased expression of F7 mRNA26194646
C039281furanfuran results in increased methylation of F7 gene22079235
C056507gemcitabinegemcitabine results in decreased expression of F7 protein20531411
D019833GenisteinGenistein results in increased expression of F7 mRNA20838740
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein12616980|1261825
C033273GestodeneF7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein]12616980|1261698
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of F7 mRNA22467014
D006589HexestrolHexestrol results in decreased expression of F7 protein2821645
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of F7 mRNA20044591
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of F71828463
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of F7 mRNA18804290
C517284monomethyl phthalatemonomethyl phthalate affects the expression of F7 mRNA26924002
D009020MorphineMorphine results in increased expression of F7 protein18980684
C523799MRK 003F7 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of F7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of F7 mRNA"25554681|2710602
D009640Norethindrone[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F7 protein14561536
C024262norethindrone acetate[Estradiol co-treated with norethindrone acetate] results in decreased expression of F7 protein17393018
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F7 protein12618251
C109079norgestimate, ethinyl estradiol drug combination"norgestimate, ethinyl estradiol drug combination results in increased expression of F7 protein"8950781
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of F7 protein15157790
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of F7 protein12618251
C516519NuvaRingNuvaRing results in increased expression of F7 protein15157790
C025589ochratoxin Aochratoxin A results in decreased expression of F7 mRNA29274910
C025589ochratoxin Aochratoxin A results in decreased expression of F7 protein29274910
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of F7 mRNA]19555225
D052638Particulate MatterParticulate Matter results in increased expression of F7 protein21029357
C046012pentanalpentanal results in decreased expression of F7 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of F7 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of F7 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of F7 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of F7 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of F7 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of F7 mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of F7 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of F7 mRNA18804290
D010634Phenobarbital[Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein19952496
D010634PhenobarbitalPhenobarbital results in decreased activity of F7 protein19952496
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of F7 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of F7 mRNA16221962|1846767
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of F7 mRNA]18467677|2005976
D011372ProgestinsProgestins inhibits the reaction [Estrogens results in increased activity of and results in increased expression of F7 protein]12456630
C005556propionaldehydepropionaldehyde results in decreased expression of F7 mRNA26079696
D011719PyrazinesPyrazines results in decreased activity of [F3 protein binds to F7 protein]14967414
D011794QuercetinQuercetin results in decreased expression of F7 mRNA21632981
C013672riddelliineriddelliine results in increased expression of F7 mRNA18047727
C089730rosiglitazonerosiglitazone results in decreased expression of F7 mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of F7 mRNA25895662
D012906SmokeSmoke results in increased secretion of F7 protein17041012
C009277sodium arsenatesodium arsenate results in decreased expression of F7 mRNA16882884
D053260SootSoot results in increased expression of F7 mRNA22461453|2655175
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of F7 mRNA22467014
D013629TamoxifenTamoxifen affects the expression of F7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of F7 mRNA19770486|2629044
D013853ThioacetamideThioacetamide results in decreased expression of F7 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of F7 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of F7 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of F7 mRNA19042947
D014520UrethaneUrethane results in decreased expression of F7 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of F7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of F7 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of F7 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of F7 protein21029357
D024482Vitamin K 2[Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein19952496
D014859WarfarinF7 gene mutant form affects the susceptibility to Warfarin20885134
D014859WarfarinF7 gene polymorphism affects the susceptibility to Warfarin14656880
D014859WarfarinFenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]9681093
D014859WarfarinWarfarin results in decreased expression of F7 protein9681093
D014859WarfarinWarfarin results in decreased activity of F7 protein20371969

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activitycontributes_toIDA24998411  
GO:0005102signaling receptor binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI3455766  8598903  8940045  9414278  15522303  15664864  
25241761  
GO:0008236serine-type peptidase activity-TAS3037537  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0002690positive regulation of leukocyte chemotaxis-IBA21873635  
GO:0002690positive regulation of leukocyte chemotaxis-IDA17991872  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007596blood coagulation-IBA21873635  
GO:0007596blood coagulation-IDA8632006  24998411  
GO:0007598blood coagulation, extrinsic pathway-TAS-  
GO:0007623circadian rhythm-IEA-  
GO:0010037response to carbon dioxide-IEA-  
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathway-IDA17991872  
GO:0016485protein processing-IDA24998411  
GO:0030194positive regulation of blood coagulation-IEA-  
GO:0030335positive regulation of cell migration-TAS18612547  
GO:0031100animal organ regeneration-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032571response to vitamin K-IEA-  
GO:0033595response to genistein-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0050927positive regulation of positive chemotaxis-IDA17991872  
GO:0051897positive regulation of protein kinase B signaling-IDA18612547  
GO:0060416response to growth hormone-IEA-  
GO:0070723response to cholesterol-IEA-  
GO:0097068response to thyroxine-IEA-  
GO:1904400response to Thyroid stimulating hormone-IEA-  
GO:1904612response to 2,3,7,8-tetrachlorodibenzodioxine-IEA-  
GO:1905217response to astaxanthin-IEA-  
GO:1905225response to thyrotropin-releasing hormone-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031982vesicle-IEA-  
GO:1905286serine-type peptidase complex-IPI24998411  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-140834Extrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-159740Gamma-carboxylation of protein precursorsTAS
R-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusTAS
R-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsTAS
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400253Circadian ClockIEA
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21110013Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)Geisen CEur J Clin Pharmacol
16100725Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. (2005 Sep 15)Shaw GMAm J Med Genet A
16353042[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age]. (2005)Dankovtseva ENKardiologiia