Gene info: ID 2159

Gene: F10

GENE ID: 2159

Synonyms: FX|FXA

Description: coagulation factor X

Gene type: protein-coding

Location: 13q34

dbXrefs: Ensembl:ENSG00000126218 MIM:613872 Vega:OTTHUMG00000017374 UniprotKB:P00742

RefSeq: NG_009258.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.615e-1 (AD) 4.742e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ISYNA1	0.619
RBPMS2	0.612
OLFML1	0.593
CLEC14A	0.588
ATP2A3	0.584
MRGPRF	0.571
COL6A2	0.564
SLC47A1	0.563
PDE5A	0.556
S1PR4	0.555

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZFHX4-AS1	-0.268
CA12	-0.262
OR4F5	-0.261
OR4F29	-0.253
LRRC3B	-0.253
MGAT4C	-0.25
NOX1	-0.249
C2orf73	-0.238
CPSF4L	-0.22
NTSR2	-0.217

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00025	Antihemophilic factor, human recombinant	BiotechDrug	139076-62-3	Approved\|Investigational	Target
DB00036	Coagulation factor VIIa Recombinant Human	BiotechDrug	102786-61-8	Approved	Target
DB00100	Coagulation Factor IX (Recombinant)	BiotechDrug	181054-95-5	Approved\|Investigational	Target
DB00170	Menadione	Small Molecule	58-27-5	Approved\|Nutraceutical	Target
DB00569	Fondaparinux sodium	Small Molecule	114870-03-0	Approved\|Investigational	Target
DB01109	Heparin	Small Molecule	9005-49-6	Approved\|Investigational	Target
DB01225	Enoxaparin	Small Molecule	9005-49-6	Approved	Target
DB03847	Gamma-Carboxy-Glutamic Acid	Small Molecule		Experimental	Target
DB04673	4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE	Small Molecule		Experimental	Target
DB05362	SSR-126517E	Small Molecule	-	Investigational	Target
DB05713	LY-517717	Small Molecule		Investigational	Target
DB06228	Rivaroxaban	Small Molecule	366789-02-8	Approved	Target
DB06245	Lanoteplase	BiotechDrug	171870-23-8	Investigational	Target
DB06406	Idraparinux	Small Molecule	162610-17-5	Investigational	Target
DB06605	Apixaban	Small Molecule	503612-47-3	Approved	Target
DB06635	Otamixaban	Small Molecule	193153-04-7	Investigational	Target
DB06920	Eribaxaban	Small Molecule	536748-46-6	Experimental	Target
DB07211	(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE	Small Molecule		Experimental	Target
DB07261	THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE	Small Molecule		Experimental	Target
DB07277	2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE	Small Molecule		Experimental	Target
DB07278	2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE	Small Molecule		Experimental	Target
DB07605	2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE	Small Molecule		Experimental	Target
DB07629	N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB07630	N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB07800	N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE	Small Molecule		Experimental	Target
DB07804	5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE	Small Molecule		Experimental	Target
DB07843	5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE	Small Molecule		Experimental	Target
DB07844	6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE	Small Molecule		Experimental	Target
DB07847	6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE	Small Molecule		Experimental	Target
DB07848	5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide	Small Molecule		Experimental	Target
DB07872	5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide	Small Molecule		Experimental	Target
DB07875	5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide	Small Molecule		Experimental	Target
DB07973	N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB07974	1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB08143	5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE	Small Molecule		Experimental	Target
DB08173	5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB08174	5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB08426	THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE	Small Molecule		Experimental	Target
DB08487	3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE	Small Molecule		Experimental	Target
DB08488	4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE	Small Molecule		Experimental	Target
DB08495	4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE	Small Molecule		Experimental	Target
DB08745	4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE	Small Molecule		Experimental	Target
DB08746	1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE	Small Molecule		Experimental	Target
DB09075	Edoxaban	Small Molecule	480449-70-5	Approved	Target
DB09109	Turoctocog alfa	BiotechDrug	1192451-26-5	Approved\|Investigational	Target
DB09258	Bemiparin	Small Molecule	91449-79-5	Approved\|Investigational	Target
DB09329	Antihemophilic Factor (Recombinant), PEGylated	BiotechDrug		Approved\|Investigational	Target
DB09332	Kappadione	Small Molecule	131-13-5	Approved	Target
DB11166	Antithrombin Alfa	BiotechDrug	84720-88-7	Approved\|Investigational	Target
DB12364	Betrixaban	Small Molecule	330942-05-7	Approved\|Investigational	Target
DB12598	Nafamostat	Small Molecule	81525-10-2	Approved\|Investigational	Target
DB13149	Protein S human	BiotechDrug		Approved	Target
DB13150	Coagulation factor VII human	BiotechDrug		Approved\|Investigational	Target
DB13151	Anti-inhibitor coagulant complex	BiotechDrug		Approved\|Investigational	Target
DB13152	Coagulation Factor IX Human	BiotechDrug	9001-28-9	Approved	Target
DB13192	Antihemophilic factor human	BiotechDrug		Approved	Target
DB13923	Emicizumab	BiotechDrug	1610943-06-0	Approved\|Investigational	Target
DB13933	Nonacog beta pegol	BiotechDrug	1175512-71-6	Approved\|Investigational	Target
DB13998	Lonoctocog alfa	BiotechDrug	1388129-63-2	Approved\|Investigational	Target
DB13999	Moroctocog alfa	BiotechDrug	284036-24-4	Approved	Target
DB11311	Prothrombin	BiotechDrug	9001-26-7	Approved	Enzyme

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of F10 mRNA"	25614096
C433826	2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine	2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine binds to and results in decreased activity of F10 protein	11495587
C433825	2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine	2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine binds to and results in decreased activity of F10 protein	11495587
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of F10 mRNA"	17547211
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of F10 mRNA"	21346803
C086910	(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid	(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid results in decreased activity of F10 protein	16084352
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of F10 mRNA"	28973690
C015060	4-chloro-1,2-diaminobenzene	"F10 gene SNP affects the susceptibility to 4-chloro-1,2-diaminobenzene"	25622337
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of F10 mRNA	19191707
C496492	abrine	abrine results in increased expression of F10 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of F10 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of F10 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of F10 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F10 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of F10 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of F10 mRNA	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of F10 mRNA	16483693
C432745	anticoagulation factor II, Agkistrodon acutus	"anticoagulation factor II, Agkistrodon acutus binds to and results in decreased activity of F10 protein modified form"	19723511
C432745	anticoagulation factor II, Agkistrodon acutus	"Calcium promotes the reaction [anticoagulation factor II, Agkistrodon acutus binds to and results in decreased activity of F10 protein modified form]"	19723511
C487081	belinostat	belinostat results in decreased expression of F10 mRNA	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F10 mRNA	22316170
D004958	Estradiol	Estradiol results in increased expression of F10 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of F10 mRNA	25181051
D002118	Calcium	"Calcium promotes the reaction [anticoagulation factor II, Agkistrodon acutus binds to and results in decreased activity of F10 protein modified form]"	19723511
D002220	Carbamazepine	Carbamazepine results in decreased expression of F10 mRNA	17381134
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of F10 protein	27704645
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of F10 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of F10 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F10 mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of F10 mRNA	24386269
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased activity of F10 protein"	4180662
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of F10 protein"	133615
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of F10 protein"	5700392
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of F10 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of F10 mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of F10 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of F10 mRNA	19770486
C093628	cyproconazole	cyproconazole results in increased expression of F10 mRNA	22334560
C569750	darexaban	darexaban results in decreased activity of F10 protein	21995444
C570990	darexaban glucuronide	darexaban glucuronide results in decreased activity of F10 protein	21995444
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of F10 mRNA	21266533
C000944	dicrotophos	dicrotophos results in decreased expression of F10 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of F10 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of F10 mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of F10 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of F10 mRNA	19638242
C060340	difethialone	F10 protein results in decreased susceptibility to difethialone	26860702
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of F10 mRNA	27638505
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of F10 mRNA	17547211
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of F10 mRNA	26924002
C035276	eicosapentaenoic acid ethyl ester	eicosapentaenoic acid ethyl ester results in decreased activity of F10 protein	14614217
D017984	Enoxaparin	Enoxaparin results in decreased activity of F10 protein	8180327
C109476	epoxiconazole	epoxiconazole results in increased expression of F10 mRNA	22334560
C418365	estradiol, norethindrone drug combination	"estradiol, norethindrone drug combination results in decreased expression of F10 protein"	14561536
D004964	Estriol	Estriol results in increased expression of F10 protein	614942
D004997	Ethinyl Estradiol	[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F10 protein	14561536
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] affects the activity of F10 protein	11720199
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of F10 mRNA	17942748
D005017	Ethyl Biscoumacetate	Ethyl Biscoumacetate results in decreased expression of F10 protein	6768192
D005017	Ethyl Biscoumacetate	Vitamin K 3 inhibits the reaction [Ethyl Biscoumacetate results in decreased expression of F10 protein]	6768192
C047360	felbamate	felbamate results in decreased expression of F10 mRNA	17381134
C025314	ferric citrate	ferric citrate results in decreased activity of F10 protein	6421970
C020748	ferrous sulfate	ferrous sulfate results in decreased activity of F10 protein	6421970
D005485	Flutamide	Flutamide results in decreased expression of F10 mRNA	24136188
C438268	fondaparinux	fondaparinux results in decreased activity of F10 protein	16084352
C069837	fullerene C60	fullerene C60 results in decreased expression of F10 mRNA	19167457
C056933	fumonisin B1	fumonisin B1 results in decreased expression of F10 mRNA	16221962
C039281	furan	furan results in decreased expression of F10 mRNA	25539665
C039281	furan	furan results in increased methylation of F10 gene	22079235
C040029	gabapentin	gabapentin results in decreased expression of F10 mRNA	17381134
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] affects the activity of F10 protein	11720199
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in decreased expression of F10 mRNA	16206274
D006418	Heme	Heme metabolite results in increased expression of F10 mRNA	19191707
D006493	Heparin	Heparin results in decreased activity of F10 protein	8950779
D006493	Heparin	Heparin results in decreased activity of F10 protein	8950779
D006493	Heparin	[Heparin binds to SERPINC1 protein] which results in decreased activity of F10 protein	21138266
D006493	Heparin	Heparin results in decreased activity of F10 protein	21138266
D017313	Fenretinide	Fenretinide results in decreased expression of F10 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of F10 mRNA	28973697
C479958	idraparinux	idraparinux results in decreased activity of F10 protein	16084352
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of F10 mRNA	25982114
C011890	kojic acid	kojic acid results in increased expression of F10 mRNA	16595896
D007854	Lead	Lead results in increased expression of F10 mRNA	19921347
C013592	mangiferin	mangiferin analog results in decreased activity of F10 protein	21732671
C561589	mangiferin heptasulfate	mangiferin heptasulfate results in decreased activity of F10 protein	21732671
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of F10 mRNA	20353558
D008628	Mercury	Mercury results in decreased expression of F10 mRNA	17547211
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of F10 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of F10 promoter"	26251327
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of F10 mRNA	22401849
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of F10 mRNA	26924002
C523799	MRK 003	F10 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of F10 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of F10 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of F10 mRNA"	27106021
C051752	nefazodone	nefazodone results in decreased expression of F10 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of F10 mRNA	25583101
D009532	Nickel	Nickel results in increased expression of F10 mRNA	24084258
C012655	nimesulide	nimesulide results in decreased expression of F10 mRNA	24136188
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of F10 mRNA	27935865
D009640	Norethindrone	[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of F10 protein	14561536
C025589	ochratoxin A	ochratoxin A results in decreased expression of F10 mRNA	29274910
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased activity of [F2 protein binds to F9 protein binds to F10 protein]	1279834
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of F10 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of F10 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of F10 mRNA	23567314
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of F10 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of F10 mRNA	19162173
C561590	persulfated 3,6-(O-glucopyranosyl)xanthone	"persulfated 3,6-(O-glucopyranosyl)xanthone results in decreased activity of F10 protein"	21732671
D010634	Phenobarbital	[Phenobarbital co-treated with Vitamin K 2] results in increased activity of F10 protein	19952496
D010634	Phenobarbital	Phenobarbital results in decreased expression of F10 mRNA	17381134
D010672	Phenytoin	Phenytoin results in decreased expression of F10 mRNA	17381134
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of F10 mRNA	15728792
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of F10 mRNA	27935865
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of F10 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of F10 mRNA	16221962
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of F10 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of F10 mRNA	18497975
C045950	propiconazole	propiconazole results in increased expression of F10 mRNA	22334560
D011441	Propylthiouracil	Propylthiouracil results in increased expression of F10 mRNA	24780913
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of F10 mRNA	25626140
D011794	Quercetin	Quercetin results in decreased expression of F10 mRNA	21632981
C500057	razaxaban	razaxaban results in decreased activity of F10 protein	16084352
C094240	reviparin	reviparin results in decreased activity of F10 protein	8180327
D000069552	Rivaroxaban	Rivaroxaban results in decreased activity of F10 protein	16084352
C089730	rosiglitazone	rosiglitazone results in decreased expression of F10 mRNA	25572481
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of F10 mRNA	25895662
C016104	sodium bichromate	sodium bichromate affects the expression of F10 mRNA	22110744
D012999	Soman	Soman results in increased expression of F10 mRNA	19281266
D053260	Soot	Soot results in increased expression of F10 mRNA	22461453\|2655175
C417062	SR 90107A-ORG 31540	SR 90107A-ORG 31540 results in decreased activity of F10 protein	8950779
C417062	SR 90107A-ORG 31540	SR 90107A-ORG 31540 results in decreased activity of F10 protein	8950779
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of F10 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of F10 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F10 mRNA	16267337
D013752	Tetracycline	Tetracycline results in decreased expression of F10 mRNA	24489787
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of F10 mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of F10 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of F10 mRNA	20133372
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of F10 mRNA	19042947
D014520	Urethane	Urethane analog results in decreased activity of F10 protein	10839461
D014635	Valproic Acid	Valproic Acid affects the expression of F10 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of F10 mRNA	17381134
D014810	Vitamin E	Vitamin E results in increased expression of F10 mRNA	19244175
D024482	Vitamin K 2	[Phenobarbital co-treated with Vitamin K 2] results in increased activity of F10 protein	19952496
D024483	Vitamin K 3	Vitamin K 3 inhibits the reaction [Ethyl Biscoumacetate results in decreased expression of F10 protein]	6768192
D014859	Warfarin	Warfarin results in decreased activity of F10 protein	20371969

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	IDA	17469850
GO:0004252	serine-type endopeptidase activity	-	IMP	12574802
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005509	calcium ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	6323392
GO:0005543	phospholipid binding	-	IDA	17469850

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IEA	-
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0007596	blood coagulation	-	IBA	21873635
GO:0007596	blood coagulation	-	IC	17469850
GO:0007596	blood coagulation	-	TAS	-
GO:0007598	blood coagulation, extrinsic pathway	-	TAS	-
GO:0030335	positive regulation of cell migration	-	TAS	18612547
GO:0051897	positive regulation of protein kinase B signaling	-	IDA	18612547

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0031233	intrinsic component of external side of plasma membrane	-	IC	17469850

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140875	Common Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS
R-HSA-159740	Gamma-carboxylation of protein precursors	TAS
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	TAS
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	TAS
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	TAS
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26288303	[Duration of therapeutic remission alcohol dependence: a role of dopamine system genes polymorphism and family history density]. (2015)	Kibitov AO	Zh Nevrol Psikhiatr Im S S Korsakova
22611694	[The questionnaire "alcohol anosognosia" is a new tool for assessment of anosognosia in patients with alcohol dependence]. (2011)	Rybakova IuV	Zh Nevrol Psikhiatr Im S S Korsakova
28784393	Predictors of coping and perceived expressed emotions in persons with alcohol dependence in India: a pilot study. (2017 Aug)	Reddy AS	Asian J Psychiatr
16930855	The EQ-5D in alcohol dependent patients: relationships among health-related quality of life, psychopathology and social functioning. (2007 Jan 12)	Gunther O	Drug Alcohol Depend
15082461	Differences in brain function between relapsing and abstaining alcohol-dependent patients, evaluated by EEG mapping. (2004 May-Jun)	Saletu-Zyhlarz GM	Alcohol Alcohol
24818357	Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese. (2014 Feb)	Yoshihara E	Nihon Arukoru Yakubutsu Igakkai Zasshi