Gene info: ID 216

Gene: ALDH1A1

GENE ID: 216

Description: aldehyde dehydrogenase 1 family member A1

Gene type: protein-coding

Location: 9q21.13

dbXrefs: Ensembl:ENSG00000165092 MIM:100640 Vega:OTTHUMG00000020019 UniprotKB:P00352

RefSeq: NG_012249.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 24

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.055e-1 (AD) 9.771e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HADHB	0.755
NDRG2	0.738
PRDX6	0.734
ANTXR1	0.72
PTN	0.712
ACAA2	0.706
ASRGL1	0.703
HSDL2	0.701
SNX5	0.699
CSRP1	0.694

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ANKRD63	-0.464
OR4F29	-0.447
OR4F5	-0.437
C4orf50	-0.435
HTR4	-0.424
GPR52	-0.419
PAQR9	-0.411
ZNF831	-0.407
GRM4	-0.406
PDYN	-0.405

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00162	Vitamin A	Small Molecule	68-26-8	Approved\|Nutraceutical	Target
DB00755	Tretinoin	Small Molecule	302-79-4	Approved\|Investigational\|Nutraceutical	Target
DB04447	1,4-Dithiothreitol	Small Molecule	3483-12-3	Experimental	Target
DB09462	Glycerin	Small Molecule	56-81-5	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of ALDH1A1 mRNA"	17070881
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of ALDH1A1 mRNA"	19162173\|1969523
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ALDH1A1 protein	22527513
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of ALDH1A1 mRNA"	22496397
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ALDH1A1 mRNA"	17998271\|2249639
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ALDH1A1 mRNA]"	22496397
C035314	1-nitropropane	1-nitropropane results in increased expression of ALDH1A1 mRNA	17070881
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in decreased expression of ALDH1A1 mRNA	26821219
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALDH1A1 mRNA"	27291303
C003585	22-hydroxycholesterol	22-hydroxycholesterol promotes the reaction [SREBF1 protein binds to ALDH1A1 promoter]	16763553
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of ALDH1A1 mRNA"	19176366
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of ALDH1A1 mRNA	22193206
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ALDH1A1 mRNA"	20959002
C057349	2,4-decadienal	"ALDH1A1 protein affects the oxidation of 2,4-decadienal"	12604195
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of ALDH1A1 mRNA"	17070881
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ALDH1A1 mRNA"	21346803
C025235	2,6-diaminotoluene	"2,6-diaminotoluene results in increased expression of ALDH1A1 mRNA"	17070881
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ALDH1A1 mRNA"	21346803
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of ALDH1A1 mRNA"	21346803
C006593	2-anthramine	2-anthramine results in increased expression of ALDH1A1 mRNA	23038007
C051750	2-hexenal	ALDH1A1 protein results in increased metabolism of 2-hexenal	21256123
C049826	2-methoxyacetaldehyde	ALDH1A1 protein results in increased oxidation of 2-methoxyacetaldehyde	18940187
C014706	2-nitro-4-phenylenediamine	2-nitro-4-phenylenediamine results in increased expression of ALDH1A1 mRNA	17070881
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of ALDH1A1 mRNA	14600272\|2248451
C016617	2-nitropropane	2-nitropropane results in increased expression of ALDH1A1 mRNA	17070881
C013166	2-nonenal	ALDH1A1 protein results in decreased susceptibility to 2-nonenal	11306050
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ALDH1A1 mRNA"	19692669
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of ALDH1A1 protein"	22649188
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of ALDH1A1 mRNA	14610520
C028676	4-acetylaminofluorene	4-acetylaminofluorene results in increased expression of ALDH1A1 mRNA	17070881
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of ALDH1A1 mRNA"	21346803
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to ALDH1A1 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH1A1 protein]	26598702
C055506	4-(diethylamino)benzaldehyde	4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]	8662658
C055506	4-(diethylamino)benzaldehyde	4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein	16316642
C055506	4-(diethylamino)benzaldehyde	ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde	25512087
C055506	4-(diethylamino)benzaldehyde	4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein	16316642
C018523	4-dimethylaminocinnamaldehyde	[4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein	10609638
C027576	4-hydroxy-2-nonenal	ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal	22339434
C027576	4-hydroxy-2-nonenal	ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal	21256123
C027576	4-hydroxy-2-nonenal	[APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal	21967605
C031335	4-hydroxyacetophenone	4-hydroxyacetophenone binds to ALDH1A1 protein	15236443
C024836	4-nitrophenol	[ALDH1A1 protein results in increased oxidation of 4-nitrophenyl acetate] results in increased chemical synthesis of [4-nitrophenol co-treated with Acetic Acid]	25450233
C008642	4-nitrophenyl acetate	ALDH1A1 protein results in increased oxidation of 4-nitrophenyl acetate	25450233
C008642	4-nitrophenyl acetate	[ALDH1A1 protein results in increased oxidation of 4-nitrophenyl acetate] results in increased chemical synthesis of [4-nitrophenol co-treated with Acetic Acid]	25450233
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ALDH1A1 mRNA	14600272\|2248451
C029370	4-toluidine	4-toluidine results in increased expression of ALDH1A1 mRNA	27638505
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of ALDH1A1 mRNA"	19695238
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to ALDH1A1 protein	27464947
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to ALDH1A1 protein	27464947
C031390	9-cis-retinal	ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of MITF mRNA]	23489423
C031390	9-cis-retinal	ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of TYR mRNA]	23489423
C031390	9-cis-retinal	ALDH1A1 protein affects the oxidation of 9-cis-retinal	17167544
C031390	9-cis-retinal	Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]	17167544
C031390	9-cis-retinal	Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]	17167544
D000079	Acetaldehyde	ALDH1A1 protein results in increased oxidation of Acetaldehyde	18940187\|2322059
D000079	Acetaldehyde	Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]	23220590
D000079	Acetaldehyde	ALDH1A1 protein results in increased metabolism of Acetaldehyde	21256123
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in decreased expression of ALDH1A1 mRNA	22285649
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH1A1 mRNA	22285649
D000079	Acetaldehyde	ALDH1A1 protein results in increased oxidation of Acetaldehyde	10998257
D000082	Acetaminophen	Acetaminophen results in decreased expression of ALDH1A1 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ALDH1A1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH1A1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH1A1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of ALDH1A1 mRNA	17202762
D019342	Acetic Acid	[ALDH1A1 protein results in increased oxidation of 4-nitrophenyl acetate] results in increased chemical synthesis of [4-nitrophenol co-treated with Acetic Acid]	25450233
D000171	Acrolein	Acrolein binds to and results in decreased activity of ALDH1A1 protein	22339434
D000171	Acrolein	ALDH1A1 protein results in increased oxidation of Acrolein	22339434
D000171	Acrolein	[NAD co-treated with propionaldehyde] inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]	22339434
D000171	Acrolein	NAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH1A1 protein]	22339434
D000171	Acrolein	propionaldehyde inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]	22339434
D000171	Acrolein	Acrolein results in increased expression of ALDH1A1 mRNA	21256123
D000171	Acrolein	ALDH1A1 protein inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]	21256123
D000171	Acrolein	ALDH1A1 protein results in decreased susceptibility to Acrolein	21256123
D000171	Acrolein	ALDH1A1 protein results in increased metabolism of Acrolein	21256123
D000249	Adenosine Monophosphate	[4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein	10609638
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of ALDH1A1 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ALDH1A1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ALDH1A1 mRNA	14600272\|2181346
D000447	Aldehydes	ALDH1A1 protein results in increased oxidation of Aldehydes	23295229
D000447	Aldehydes	[ALDH1A1 protein results in increased oxidation of Aldehydes] which results in increased chemical synthesis of Carboxylic Acids	23295229
C006446	aldophosphamide	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide	10856427
C006446	aldophosphamide	ALDH1A1 results in increased oxidation of aldophosphamide	8662658
D000493	Allopurinol	Allopurinol results in increased expression of ALDH1A1 mRNA	28138970
C038491	allyl sulfide	allyl sulfide results in increased expression of ALDH1A1 mRNA	17998271
C038491	allyl sulfide	allyl sulfide results in increased expression of ALDH1A1 mRNA	19695238
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ALDH1A1 mRNA	28522335
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ALDH1A1 protein	26072098
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA	17785943
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ALDH1A1 mRNA	21298039
D000638	Amiodarone	Amiodarone affects the expression of ALDH1A1 mRNA	18355885\|1948338
D000639	Amitriptyline	Amitriptyline affects the expression of ALDH1A1 mRNA	18355885
D000661	Amphetamine	Amphetamine results in decreased expression of ALDH1A1 protein	23459167
D000661	Amphetamine	MDK gene mutant form promotes the reaction [Amphetamine results in decreased expression of ALDH1A1 protein]	23459167
D001151	Arsenic	Arsenic results in increased expression of ALDH1A1 mRNA	25922126
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH1A1 protein]	26598702
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ALDH1A1 mRNA	24061648
C015001	arsenite	arsenite results in increased expression of ALDH1A1 mRNA	25543096
D001241	Aspirin	Aspirin binds to ALDH1A1 protein	15236443
D001379	Azathioprine	Azathioprine results in increased expression of ALDH1A1 mRNA	28138970
C547126	AZM551248	AZM551248 results in decreased expression of ALDH1A1 mRNA	22323515
D001414	Bacitracin	Bacitracin results in increased expression of ALDH1A1 mRNA	18289764
C032175	benzaldehyde	ALDH1A1 protein results in increased metabolism of benzaldehyde	21256123
C032175	benzaldehyde	ALDH1A1 protein results in increased oxidation of benzaldehyde	10998257
D001547	Benzaldehydes	Benzaldehydes results in decreased activity of ALDH1A1 protein	22079344
D001553	Benzbromarone	Benzbromarone affects the expression of ALDH1A1 mRNA	19483382
D001554	Benzene	Benzene affects the expression of ALDH1A1 mRNA	15878777
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ALDH1A1 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH1A1 mRNA	21295105
C047723	benzophenone	benzophenone results in increased expression of ALDH1A1 mRNA	22584684
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ALDH1A1 mRNA	20127859
C031403	benzyl isothiocyanate	benzyl isothiocyanate results in increased expression of ALDH1A1 mRNA	28821405
C031403	benzyl isothiocyanate	benzyl isothiocyanate results in increased expression of ALDH1A1 protein	28821405
C031403	benzyl isothiocyanate	NFE2L2 protein promotes the reaction [benzyl isothiocyanate results in increased expression of ALDH1A1 mRNA]	28821405
C038328	BEP protocol	BEP protocol results in increased expression of ALDH1A1 mRNA	18987330\|2320077
D004958	Estradiol	Estradiol results in increased expression of ALDH1A1 mRNA	25543096
C099952	bifenthrin	bifenthrin results in increased expression of ALDH1A1 mRNA	26071804
C006780	bisphenol A	bisphenol A results in decreased expression of ALDH1A1 protein	28273538
C006780	bisphenol A	bisphenol A affects the expression of ALDH1A1 mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of ALDH1A1 mRNA	25181051
D001761	Bleomycin	Bleomycin results in decreased expression of ALDH1A1 protein	25933445
C032036	bromobenzene	bromobenzene metabolite binds to ALDH1A1 protein	17305373
C032036	bromobenzene	bromobenzene results in increased expression of ALDH1A1 mRNA	12628495
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ALDH1A1 mRNA	22079614
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of ALDH1A1 mRNA	17998271
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of ALDH1A1 mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ALDH1A1 mRNA	15336504
D002104	Cadmium	Cadmium results in decreased expression of ALDH1A1 mRNA	25922126
D002104	Cadmium	Cadmium results in increased expression of ALDH1A1 mRNA	24067728
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALDH1A1 mRNA	27224422
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA	19840844
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ALDH1A1 mRNA	25993096
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]"	20230807
D002118	Calcium	Calcium results in decreased activity of ALDH1A1 protein	16603817
D002220	Carbamazepine	Carbamazepine results in increased expression of ALDH1A1 mRNA	17381134\|2813897
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ALDH1A1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ALDH1A1 mRNA	16644059
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ALDH1A1 protein	16845489
D002264	Carboxylic Acids	[ALDH1A1 protein results in increased oxidation of Aldehydes] which results in increased chemical synthesis of Carboxylic Acids	23295229
C054133	casticin	casticin results in increased expression of ALDH1A1 mRNA	27862857
C084597	chlorcyclizine	chlorcyclizine results in increased expression of ALDH1A1 mRNA	21058326
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of ALDH1A1 mRNA	17851650
D002725	Chloroform	Chloroform results in increased expression of ALDH1A1 mRNA	21813463
D002746	Chlorpromazine	[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
D002791	Cholesterol, Dietary	"Cholesterol, Dietary metabolite results in increased expression of ALDH1A1 mRNA"	16763553
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
D002793	Cholic Acids	[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
C039671	ciglitazone	ciglitazone results in decreased expression of ALDH1A1 mRNA	22193206
D002927	Cimetidine	Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]	23220590
C019304	ciprofibrate	ciprofibrate results in increased expression of ALDH1A1 mRNA	17998271\|2722589
C019304	ciprofibrate	ciprofibrate results in increased expression of ALDH1A1 mRNA	27225895
D002939	Ciprofloxacin	Ciprofloxacin results in increased expression of ALDH1A1 protein	26947806
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH1A1 mRNA	17585979
D002994	Clofibrate	[Clofibrate results in increased activity of PPARA protein] which results in increased expression of ALDH1A1 mRNA	22496397
D002994	Clofibrate	Clofibrate results in increased expression of ALDH1A1 mRNA	17585979\|2249639
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH1A1 mRNA]	17585979
D002994	Clofibrate	PPARA protein affects the reaction [Clofibrate results in increased expression of ALDH1A1 mRNA]	22496397
D002994	Clofibrate	Clofibrate affects the expression of ALDH1A1 mRNA	19483382
D002994	Clofibrate	Clofibrate results in increased expression of ALDH1A1 mRNA	12851107
D002995	Clofibric Acid	Clofibric Acid results in increased expression of ALDH1A1 mRNA	17998271
D002995	Clofibric Acid	Clofibric Acid results in increased expression of ALDH1A1 mRNA	17602206
D002997	Clomipramine	Clomipramine affects the expression of ALDH1A1 mRNA	18355885
D003024	Clozapine	Clozapine results in increased expression of ALDH1A1 mRNA	17266109
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in decreased expression of ALDH1A1 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALDH1A1 mRNA	17553155\|1932097
C018021	cobaltous chloride	[cobaltous chloride promotes the reaction [HIF3A protein binds to ARNT protein]] which results in increased expression of ALDH1A1 mRNA	14729976
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALDH1A1 mRNA	14729976
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ALDH1A1 mRNA	24386269
D009243	NAD	ALDH1A1 protein binds to and results in increased reduction of NAD	25450233
D009243	NAD	[ALDH1A1 protein binds to NAD] which results in increased oxidation of propionaldehyde	25450233
D009243	NAD	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide	10856427
D009243	NAD	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of propionaldehyde	10559215\|1085642
D009243	NAD	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde	10559215
D009243	NAD	NAD binds to and results in increased activity of ALDH1A1 protein	25450233
D009243	NAD	[NAD co-treated with propionaldehyde] inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]	22339434
D009243	NAD	NAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH1A1 protein]	22339434
D009243	NAD	NAD results in increased activity of ALDH1A1 protein	21256123
D009243	NAD	Magnesium affects the reaction [NAD binds to ALDH1A1 protein]	23295229
D009243	NAD	NAD binds to ALDH1A1 protein	23295229
D003300	Copper	ALDH1A1 protein binds to Copper	15359738
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ALDH1A1 mRNA	15467011
D003314	Corn Oil	Corn Oil affects the expression of ALDH1A1 mRNA	16360708
C030123	coumarin	coumarin results in increased expression of ALDH1A1 mRNA	18480146
D003520	Cyclophosphamide	ALDH1A1 protein affects the susceptibility to Cyclophosphamide	18854779
D003520	Cyclophosphamide	ALDH1A1 protein results in decreased susceptibility to Cyclophosphamide	12513786
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of ALDH1A1 mRNA	17403535
D003520	Cyclophosphamide	ALDH1A1 protein affects the susceptibility to Cyclophosphamide	25641190
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALDH1A1 mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALDH1A1 mRNA	19770486\|2383089
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ALDH1A1 mRNA	29038839
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of ALDH1A1 mRNA	29038839
C093628	cyproconazole	cyproconazole results in increased expression of ALDH1A1 mRNA	25182419\|2903883
D000069439	Dasatinib	Dasatinib results in increased expression of ALDH1A1 mRNA	20579391
C014347	decitabine	decitabine affects the expression of ALDH1A1 mRNA	25922126
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased expression of ALDH1A1 mRNA	22640920
D003907	Dexamethasone	Dexamethasone affects the expression of ALDH1A1 mRNA	15102944
D016190	Carboplatin	ALDH1A1 protein affects the susceptibility to Carboplatin	18854779
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of ALDH1A1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of ALDH1A1 mRNA	11099651
D002945	Cisplatin	Cisplatin results in increased expression of ALDH1A1 mRNA	21151649
D002945	Cisplatin	Cisplatin results in increased expression of ALDH1A1 mRNA	18289764\|2202380
D004006	Dichlorvos	Dichlorvos results in increased expression of ALDH1A1 mRNA	21813463
C000944	dicrotophos	dicrotophos results in decreased expression of ALDH1A1 mRNA	28302478
C121718	dicyclanil	dicyclanil results in increased expression of ALDH1A1 mRNA	15664270
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of ALDH1A1 mRNA	26924002
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ALDH1A1 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in increased expression of ALDH1A1 mRNA	25016146
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ALDH1A1 mRNA	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ALDH1A1 mRNA	17998271\|1924581
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ALDH1A1 mRNA	22584684
C014476	diethyl maleate	diethyl maleate affects the reduction of ALDH1A1 protein	19843705
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ALDH1A1 mRNA	21527772
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH1A1 mRNA	21295105
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDH1A1 mRNA	23830814\|2894339
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ALDH1A1 mRNA	17602206\|2181346
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	22129741
D004052	Diethylnitrosamine	[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	18977376
D004052	Diethylnitrosamine	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	22687989
C089799	diheptyl phthalate	diheptyl phthalate results in increased expression of ALDH1A1 mRNA	22112501
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of ALDH1A1 mRNA	27638505
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ALDH1A1 mRNA	14600272\|1707298
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of ALDH1A1 mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of ALDH1A1 mRNA	22193206
C493087	diphenylarsinic acid	diphenylarsinic acid results in increased expression of ALDH1A1 protein	17321558
D004221	Disulfiram	Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide]	8562935
D004221	Disulfiram	Disulfiram results in decreased activity of ALDH1A1 protein	21035945
D004221	Disulfiram	Disulfiram results in decreased activity of ALDH1A1 protein	10998257
D004221	Disulfiram	Disulfiram binds to and results in decreased activity of ALDH1A1 protein	2987944
D004221	Disulfiram	Disulfiram results in decreased activity of ALDH1A1 protein	8562935
D004237	Diuron	Diuron results in increased expression of ALDH1A1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased expression of ALDH1A1 mRNA	15033991\|1927712
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of ALDH1A1 mRNA	20064776
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ALDH1A1 mRNA	29038839
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of ALDH1A1 mRNA	29038839
C109476	epoxiconazole	epoxiconazole results in increased expression of ALDH1A1 mRNA	25182419\|2903883
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of ALDH1A1 mRNA	24412560
D000431	Ethanol	Ethanol results in increased expression of ALDH1A1 mRNA	16098508
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALDH1A1 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALDH1A1 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALDH1A1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALDH1A1 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALDH1A1 mRNA	12655037\|1583489
D005001	Ethionine	Ethionine affects the expression of ALDH1A1 mRNA	19483382
D005015	Ethoxyquin	Ethoxyquin results in increased expression of ALDH1A1 mRNA	17998271
D005015	Ethoxyquin	Ethoxyquin results in increased expression of ALDH1A1 mRNA	19695238
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of ALDH1A1 mRNA	23649840
C047360	felbamate	felbamate results in increased expression of ALDH1A1 mRNA	17381134
C082360	fipronil	fipronil results in increased expression of ALDH1A1 mRNA	23962444
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA	17070881\|2258468
D005472	Fluorouracil	ALDH1A1 protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in decreased expression of ALDH1A1 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of ALDH1A1 protein	17311803
D005492	Folic Acid	Folic Acid affects the expression of ALDH1A1 mRNA	17868486
C056933	fumonisin B1	fumonisin B1 results in increased expression of ALDH1A1 mRNA	16221962
C039281	furan	furan results in increased expression of ALDH1A1 mRNA	25539665
D005665	Furosemide	Furosemide results in increased expression of ALDH1A1 mRNA	28138970
C064925	gadodiamide	gadodiamide results in increased expression of ALDH1A1 mRNA	20959327
C056507	gemcitabine	gemcitabine results in decreased expression of ALDH1A1 protein	20940707
C056507	gemcitabine	sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]	20940707
D019833	Genistein	Genistein results in decreased expression of ALDH1A1 mRNA	26865667
D005839	Gentamicins	Gentamicins results in decreased expression of ALDH1A1 mRNA	18289764
D005897	Glafenine	Glafenine results in decreased expression of ALDH1A1 mRNA	24136188
D005978	Glutathione	Glutathione deficiency results in increased expression of ALDH1A1 mRNA	20621112
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ALDH1A1 mRNA	20044591\|2341063
C012353	hydroperoxyisophosphamide	ALDH1A1 protein results in decreased susceptibility to hydroperoxyisophosphamide	8662658
D007099	Imipramine	Imipramine affects the expression of ALDH1A1 mRNA	18355885
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in increased expression of ALDH1A1 protein	21948866
C474021	indirubin-3'-monoxime	Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein]	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of ALDH1A1 mRNA	21948866
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of ALDH1A1 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	22129741
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH1A1 mRNA	25613284
C051890	irinotecan	irinotecan metabolite results in decreased expression of ALDH1A1 mRNA	15956246
C051890	irinotecan	irinotecan results in decreased expression of ALDH1A1 mRNA	15956246
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ALDH1A1 mRNA	24435446
C410337	K 7174	K 7174 results in decreased expression of ALDH1A1 mRNA	24086573
D007654	Ketoconazole	Ketoconazole affects the expression of ALDH1A1 mRNA	18355885
C099406	L 742694	L 742694 affects the expression of ALDH1A1 mRNA	15102944
C490728	lapatinib	[lapatinib results in decreased susceptibility to lapatinib] which results in increased expression of ALDH1A1 protein	26643609
C008261	lead acetate	lead acetate results in increased expression of ALDH1A1 mRNA	22839698
C052901	lemongrass oil	lemongrass oil affects the expression of ALDH1A1 mRNA	25976427
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of ALDH1A1 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1A1 mRNA"	20371263
D008070	Lipopolysaccharides	Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein]	21948866
C048341	mafosfamide	4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]	8662658
C048341	mafosfamide	ALDH1A1 protein results in decreased susceptibility to mafosfamide	8662658
D008274	Magnesium	Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]	17167544
D008274	Magnesium	Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]	17167544
D008274	Magnesium	Magnesium results in decreased activity of ALDH1A1 protein	16603817
D008274	Magnesium	Magnesium affects the reaction [NAD binds to ALDH1A1 protein]	23295229
D015636	Magnesium Chloride	Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]	17167544
D015636	Magnesium Chloride	Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]	17167544
D015636	Magnesium Chloride	Magnesium Chloride results in decreased activity of ALDH1A1 protein	10998257
D008315	Malondialdehyde	ALDH1A1 protein results in increased oxidation of Malondialdehyde	22339434
D008315	Malondialdehyde	ALDH1A1 protein results in increased metabolism of Malondialdehyde	21256123
D008345	Manganese	Manganese results in decreased activity of ALDH1A1 protein	16603817
C087936	maphosphamide	ALDH1A1 protein results in decreased susceptibility to maphosphamide	8562935
C087936	maphosphamide	Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide]	8562935
D000069997	Mastic Resin	[Mastic Resin co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	18977376
D008701	Methapyrilene	Methapyrilene results in increased expression of ALDH1A1 mRNA	21813463\|2248451
D008727	Methotrexate	Methotrexate results in decreased expression of ALDH1A1 mRNA	24657277
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ALDH1A1 mRNA	23649840
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA	19840844
D008770	Methylnitrosourea	Methylnitrosourea results in decreased expression of ALDH1A1 mRNA	25922126
C015358	methylparaben	methylparaben results in increased expression of ALDH1A1 mRNA	27581495
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]"	20230807
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of ALDH1A1 mRNA	29191790
D008825	Miconazole	Miconazole results in increased expression of ALDH1A1 mRNA	22262564
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of ALDH1A1 mRNA	26924002
C100088	monuron	monuron results in increased expression of ALDH1A1 mRNA	22584684
C500085	muraglitazar	muraglitazar results in increased expression of ALDH1A1 mRNA	21515302
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ALDH1A1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ALDH1A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ALDH1A1 mRNA"	25554681\|2562005
C000621033	napabucasin	napabucasin results in decreased expression of ALDH1A1 mRNA	25605917
C031721	naphthalene	naphthalene metabolite binds to ALDH1A1 protein	16453347
C031721	naphthalene	CFTR gene mutant form affects the reaction [naphthalene results in decreased expression of ALDH1A1 protein]	19438287
C031721	naphthalene	[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of ALDH1A1 mRNA	19438287
C031721	naphthalene	[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of ALDH1A1 protein	19438287
C031721	naphthalene	naphthalene results in decreased expression of ALDH1A1 mRNA	19438287
C031721	naphthalene	naphthalene results in decreased expression of ALDH1A1 protein	19438287
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA	27344345
C053320	n-butoxyacetaldehyde	ALDH1A1 protein results in increased oxidation of n-butoxyacetaldehyde	18940187
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of ALDH1A1 mRNA	19812364
C066471	NCS 382	NCS 382 results in increased expression of ALDH1A1 mRNA	28119166
C051752	nefazodone	nefazodone results in increased expression of ALDH1A1 mRNA	24136188
C010463	n-hexanal	ALDH1A1 protein results in increased oxidation of n-hexanal	23220587
D009532	Nickel	Nickel results in decreased expression of ALDH1A1 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride results in increased expression of ALDH1A1 protein	26962057
C022838	nickel chloride	nickel chloride results in decreased expression of ALDH1A1 mRNA	12729255\|1464567
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of ALDH1A1 mRNA	12729255
D009534	Niclosamide	Niclosamide results in decreased expression of ALDH1A1 protein	24736023
D009538	Nicotine	Nicotine results in increased activity of ALDH1A1 protein	23219715
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of ALDH1A1 mRNA	24136188
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of ALDH1A1 mRNA	12102619
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of ALDH1A1 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of ALDH1A1 mRNA	19716841
C025589	ochratoxin A	ochratoxin A results in decreased expression of ALDH1A1 mRNA	23358140
D019301	Oleic Acid	Oleic Acid results in decreased expression of ALDH1A1 mRNA	26739624
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA	19840844
C026209	oltipraz	NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA]	22496397
C026209	oltipraz	[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA	22496397
C026209	oltipraz	oltipraz results in increased expression of ALDH1A1 mRNA	17998271\|2249639
D009853	Omeprazole	Omeprazole affects the expression of ALDH1A1 mRNA	19483382
D009853	Omeprazole	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA	22687989
C016340	o,p'-DDT	"o,p'-DDT affects the expression of ALDH1A1 mRNA"	17984292
D009966	Orphenadrine	Orphenadrine affects the expression of ALDH1A1 mRNA	23665939
D010269	Paraquat	Paraquat results in increased expression of ALDH1A1 mRNA	12595580
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of ALDH1A1 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNA	21723365
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNA	19429403\|2093613
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ALDH1A1 mRNA	16221955\|1869254
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of ALDH1A1 mRNA	18281256
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALDH1A1 mRNA	17681415\|1942940
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALDH1A1 mRNA	16221955\|1916217
C011272	perfosfamide	ALDH1A1 protein results in decreased susceptibility to perfosfamide	16614850\|8662658
D010622	Phencyclidine	Phencyclidine results in increased expression of ALDH1A1 mRNA	17266109
D010634	Phenobarbital	Phenobarbital results in increased expression of ALDH1A1 mRNA	17998271
D010634	Phenobarbital	Phenobarbital results in increased expression of ALDH1A1 mRNA	17381134\|1916217
D010672	Phenytoin	Phenytoin results in increased expression of ALDH1A1 mRNA	17381134
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of ALDH1A1 mRNA	22484513
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ALDH1A1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ALDH1A1 mRNA	16221962\|1742611
C006253	pirinixic acid	pirinixic acid affects the expression of ALDH1A1 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of ALDH1A1 mRNA	16940010\|1916217
D028321	Plant Preparations	Plant Preparations affects the expression of ALDH1A1 mRNA	16046712
D017035	Pravastatin	Pravastatin results in decreased expression of ALDH1A1 mRNA	16763553\|2722589
D017035	Pravastatin	Pravastatin results in decreased expression of ALDH1A1 mRNA	27225895
D011223	Praziquantel	Praziquantel results in increased expression of ALDH1A1 mRNA	21813463
D011285	Pregnenolone Carbonitrile	NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA]	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]	20693526
D011285	Pregnenolone Carbonitrile	[Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]] which results in increased expression of ALDH1A1 mRNA	20693526\|2069352
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA	17998271\|2249639
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA	19162173
C045362	prochloraz	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ALDH1A1 mRNA	29038839
C045362	prochloraz	prochloraz results in increased expression of ALDH1A1 mRNA	25182419
D011374	Progesterone	Progesterone affects the expression of ALDH1A1 mRNA	17251523
D011374	Progesterone	Progesterone results in decreased expression of ALDH1A1 mRNA	22238285
D011374	Progesterone	[Progesterone results in increased activity of PGR protein] which results in increased expression of ALDH1A1 mRNA	15845616
C045950	propiconazole	propiconazole results in increased expression of ALDH1A1 mRNA	21278054
C045950	propiconazole	propiconazole results in increased expression of ALDH1A1 mRNA	17178689\|1940940
C005556	propionaldehyde	[ALDH1A1 protein binds to NAD] which results in increased oxidation of propionaldehyde	25450233
C005556	propionaldehyde	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of propionaldehyde	10559215\|1085642
C005556	propionaldehyde	ALDH1A1 protein results in increased oxidation of propionaldehyde	21349255
C005556	propionaldehyde	[NAD co-treated with propionaldehyde] inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]	22339434
C005556	propionaldehyde	propionaldehyde inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]	22339434
C005556	propionaldehyde	ALDH1A1 protein results in increased metabolism of propionaldehyde	21256123
C005556	propionaldehyde	ALDH1A1 protein results in increased oxidation of propionaldehyde	10998257
D011441	Propylthiouracil	Propylthiouracil affects the expression of ALDH1A1 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ALDH1A1 mRNA	24780913
D011748	Pyrogallol	Pyrogallol results in increased expression of ALDH1A1 mRNA	20362636
D011748	Pyrogallol	Silymarin inhibits the reaction [Pyrogallol results in increased expression of ALDH1A1 mRNA]	20362636
D011791	Quartz	Quartz results in decreased expression of ALDH1A1 mRNA	27917503
D011791	Quartz	Quartz results in increased expression of ALDH1A1 protein	27917503
D011794	Quercetin	Quercetin results in decreased expression of ALDH1A1 mRNA	21632981
C502851	quinocetone	quinocetone results in increased expression of ALDH1A1 protein	27046791
C059514	resveratrol	resveratrol results in decreased activity of ALDH1A1 protein	22692956
D012172	Retinaldehyde	ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]	10559215
D012172	Retinaldehyde	ALDH1A1 protein binds to and results in increased oxidation of Retinaldehyde	23220587
D012172	Retinaldehyde	[ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde	10559215
D012172	Retinaldehyde	ALDH1A1 protein affects the oxidation of Retinaldehyde	17167544
D012172	Retinaldehyde	Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]	17167544
D012172	Retinaldehyde	Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]	17167544
D012172	Retinaldehyde	ALDH1A1 protein results in increased oxidation of Retinaldehyde	17473173
C525876	retinal dimer	ALDH1A1 protein results in increased oxidation of retinal dimer	10998257
D012176	Retinoids	ALDH1A1 protein results in increased metabolism of Retinoids	16837774
C488333	Ro 65-7199	Ro 65-7199 affects the expression of ALDH1A1 mRNA	14610520
C089730	rosiglitazone	rosiglitazone results in increased expression of ALDH1A1 mRNA	21515302
C010327	salinomycin	salinomycin results in decreased expression of ALDH1A1 mRNA	25499043
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of ALDH1A1 protein	25895662
D012834	Silver	Silver results in increased expression of ALDH1A1 mRNA	26014281
D012834	Silver	Silver results in increased expression of ALDH1A1 mRNA	27131904
D012838	Silymarin	Silymarin inhibits the reaction [Pyrogallol results in increased expression of ALDH1A1 mRNA]	20362636
C073220	S-methyl N,N-diethylthiolcarbamate sulfoxide	"S-methyl N,N-diethylthiolcarbamate sulfoxide results in decreased activity of ALDH1A1 protein"	10998257
C017947	sodium arsenite	sodium arsenite results in increased expression of ALDH1A1 mRNA	27224422
C017947	sodium arsenite	sodium arsenite affects the expression of ALDH1A1 mRNA	17450228
C016104	sodium bichromate	sodium bichromate results in increased expression of ALDH1A1 mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of ALDH1A1 mRNA	27257137
D012999	Soman	Soman results in decreased expression of ALDH1A1 mRNA	19281266
D053260	Soot	Soot results in decreased expression of ALDH1A1 mRNA	26551751
D053260	Soot	Soot results in increased expression of ALDH1A1 mRNA	22461453
D013148	Spironolactone	Spironolactone results in increased expression of ALDH1A1 mRNA	17998271
C075117	squalestatin 1	squalestatin 1 results in increased expression of ALDH1A1 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of ALDH1A1 mRNA	27225895
C031183	stearic acid	stearic acid results in decreased expression of ALDH1A1 protein	26739624
D013311	Streptozocin	Streptozocin results in increased expression of ALDH1A1 mRNA	25905778
C016766	sulforafan	ALDH1A1 protein binds to sulforafan	21838287
C016766	sulforafan	sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]	20940707
C016766	sulforafan	sulforafan results in decreased expression of ALDH1A1 protein	20940707
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1A1 mRNA"	20371263
C446685	systhane	systhane results in increased expression of ALDH1A1 mRNA	17178689\|1940940
D013605	T-2 Toxin	T-2 Toxin affects the expression of ALDH1A1 protein	26141394
D013605	T-2 Toxin	T-2 Toxin results in increased expression of ALDH1A1 mRNA	26141394
D016559	Tacrolimus	Tacrolimus results in decreased expression of ALDH1A1 mRNA	25270620
C501413	tesaglitazar	tesaglitazar results in increased expression of ALDH1A1 mRNA	21515302
D013739	Testosterone	Testosterone results in increased expression of ALDH1A1 mRNA	20403060
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALDH1A1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALDH1A1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in decreased expression of ALDH1A1 mRNA	22496397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALDH1A1 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALDH1A1 mRNA	14729976
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALDH1A1 mRNA	18796159\|2121527
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ALDH1A1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of ALDH1A1 mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA	19840844
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH1A1 mRNA	25613284
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDH1A1 mRNA	23830814\|2894339
D013853	Thioacetamide	Thioacetamide affects the expression of ALDH1A1 mRNA	19483382
D013853	Thioacetamide	Thioacetamide results in increased expression of ALDH1A1 mRNA	23411599
D013852	Thiotepa	ALDH1A1 protein affects the susceptibility to Thiotepa	18854779
C009495	titanium dioxide	titanium dioxide results in increased phosphorylation of ALDH1A1 protein	21439344
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in decreased expression of ALDH1A1 mRNA	23825117
C009495	titanium dioxide	titanium dioxide results in decreased expression of ALDH1A1 mRNA	23557971\|2776080
C423915	TO-901317	TO-901317 promotes the reaction [SREBF1 protein binds to ALDH1A1 promoter]	16763553
D014050	Toluene	Toluene affects the expression of ALDH1A1 mRNA	18653662
C034697	transplatin	transplatin results in decreased expression of ALDH1A1 mRNA	11099651
D014212	Tretinoin	[ALDH1A1 protein co-treated with SDR16C5 protein] results in increased chemical synthesis of Tretinoin	27793605
D014212	Tretinoin	Tretinoin results in decreased activity of ALDH1A1 protein	16614850
D014212	Tretinoin	Tretinoin results in decreased expression of ALDH1A1 protein	16614850
D014212	Tretinoin	Tretinoin results in decreased expression of and results in decreased activity of ALDH1A1 protein	15470086
D014212	Tretinoin	ALDH1A1 protein results in increased chemical synthesis of Tretinoin	16207763\|1883196
D014212	Tretinoin	[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in decreased expression of ALDH1A1 mRNA	24005908
D014212	Tretinoin	Tretinoin results in increased expression of ALDH1A1 mRNA	12834868
D014212	Tretinoin	ALDH1A1 protein results in increased chemical synthesis of Tretinoin	17497177\|2113883
D014212	Tretinoin	[DHRS9 protein affects the expression of ALDH1A1 mRNA] which affects the chemical synthesis of Tretinoin	21138835
D014212	Tretinoin	[DHRS9 protein affects the expression of ALDH1A1 protein] which affects the chemical synthesis of Tretinoin	21138835
D014212	Tretinoin	ALDH1A1 protein results in increased chemical synthesis of Tretinoin	17473173\|2321971
C032910	triadimefon	triadimefon results in increased expression of ALDH1A1 mRNA	17178689\|1940940
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ALDH1A1 mRNA	19254012
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ALDH1A1 mRNA	19448997
C052920	trimethylarsine oxide	trimethylarsine oxide results in increased expression of ALDH1A1 mRNA	17481689
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of ALDH1A1 mRNA	21346803
C057693	troglitazone	troglitazone results in increased expression of ALDH1A1 mRNA	21515302
C080163	trovafloxacin	trovafloxacin results in decreased expression of ALDH1A1 mRNA	24136188
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in decreased expression of ALDH1A1 mRNA	20105288
D014520	Urethane	Urethane results in decreased expression of ALDH1A1 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of ALDH1A1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of ALDH1A1 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of ALDH1A1 mRNA	17381134\|2813897
D014640	Vancomycin	Vancomycin results in decreased expression of ALDH1A1 mRNA	18289764
C025643	vinclozolin	vinclozolin affects the expression of ALDH1A1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of ALDH1A1 mRNA	22570695
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ALDH1A1 mRNA	26682919
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in decreased expression of ALDH1A1 mRNA	23825117
D014800	Vitallium	Vitallium analog results in decreased expression of ALDH1A1 mRNA	23825117
D014801	Vitamin A	ALDH1A1 protein results in increased oxidation of Vitamin A	23219715
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ALDH1A1 mRNA	23410634
C574123	walrycin A	walrycin A results in increased expression of ALDH1A1 mRNA	22314385
D019820	Xanthine	Xanthine analog results in decreased activity of ALDH1A1 protein	25450233
D015032	Zinc	Zinc results in decreased activity of ALDH1A1 protein	16603817

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001758	retinal dehydrogenase activity	-	ISS	-
GO:0001758	retinal dehydrogenase activity	-	TAS	-
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	EXP	224930
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	IBA	21873635
GO:0004029	aldehyde dehydrogenase (NAD) activity	-	IDA	4015840 25450233
GO:0005096	GTPase activator activity	-	TAS	1709013
GO:0005497	androgen binding	-	TAS	1709013
GO:0018479	benzaldehyde dehydrogenase (NAD+) activity	-	IBA	21873635
GO:0051287	NAD binding	-	ISS	12693930

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001523	retinoid metabolic process	-	ISS	-
GO:0006069	ethanol oxidation	-	TAS	-
GO:0006081	cellular aldehyde metabolic process	-	TAS	1709013
GO:0042572	retinol metabolic process	-	IEA	-
GO:0043547	positive regulation of GTPase activity	-	IEA	-
GO:0055114	oxidation-reduction process	-	IDA	25450233
GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	TAS	2987944
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145

KEGG ID	KEGG Term
hsa00830	Retinol metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-5362517	Signaling by Retinoic Acid	TAS
R-HSA-5365859	RA biosynthesis pathway	TAS
R-HSA-5652084	Fructose metabolism	TAS
R-HSA-70350	Fructose catabolism	TAS
R-HSA-71384	Ethanol oxidation	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21083667	Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)	Liu J	Alcohol Clin Exp Res
15597079	Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. (2004 Oct)	Ehlers CL	Alcohol Clin Exp Res
19706361	Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. (2009 Jul)	Moore SM	Hum Genomics
25270064	Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. (2014 Dec)	Peng Q	Am J Med Genet B Neuropsychiatr Genet
10971205	Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)	Vasiliou V	Pharmacology
26458734	Genome-wide association study of body mass index in subjects with alcohol dependence. (2017 Mar)	Polimanti R	Addict Biol
28512340	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. (2017 May 16)	Yang HC	Sci Rep
17286337	Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago. (2007 Mar)	Moore S	J Stud Alcohol Drugs
17920722	ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors. (2008 Mar)	Patel M	Lung Cancer
21349255	Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. (2011 May 30)	Parajuli B	Chem Biol Interact
18331377	Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)	Kuo PH	Alcohol Clin Exp Res
27238567	Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer. (2016 Aug 28)	Kim JY	Cancer Lett
26518146	Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells. (2016 Jan 28)	Liu Y	Cancer Lett
14506398	Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. (2003 Sep)	Spence JP	Alcohol Clin Exp Res
22617249	Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome. (2012 Aug)	Li X	J Thorac Oncol
19298322	Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. (2009 May)	Sherva R	Alcohol Clin Exp Res
17718395	Variations in ADH and ALDH in Southwest California Indians. (2007)	Ehlers CL	Alcohol Res Health
17718396	Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. (2007)	Scott DM	Alcohol Res Health
17718398	Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007)	Moore S	Alcohol Res Health
24567230	Haplotype-based study of the association of alcohol and acetaldehyde-metabolising genes with alcohol dependence (with or without comorbid anxiety symptoms) in a Cape Mixed Ancestry population. (2014 Jun)	Crawford A	Metab Brain Dis
26863581	Ethanol-metabolizing activities and isozyme protein contents of alcohol and aldehyde dehydrogenases in human liver: phenotypic traits of the ADH1B2 and ALDH22 variant gene alleles. (2016 Feb 9)	Chiang CP	Pharmacogenet Genomics
23799031	Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. (2013)	Zhang H	PLoS One
19129088	The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population. (2008 Sep)	Lind PA	Hum Genomics
23236537	Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance. (2013)	Okudela K	Int J Clin Exp Pathol