Gene info: ID 2161

Gene: F12

GENE ID: 2161

Synonyms: HAE3|HAEX|HAF

Description: coagulation factor XII

Gene type: protein-coding

Location: 5q35.3

dbXrefs: Ensembl:ENSG00000131187 MIM:610619 Vega:OTTHUMG00000163403 UniprotKB:P00748

RefSeq: NG_007568.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.521e-1 (AD) 8.555e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EFNA3	0.795
RASSF7	0.794
IL34	0.771
B9D2	0.769
LYPLA2	0.768
WDR74	0.763
DAGLB	0.757
DNAL4	0.756
SPATA33	0.756
ACHE	0.755

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PARD3B	-0.493
ANGPTL1	-0.462
ASB4	-0.449
ARHGAP42	-0.446
MBNL3	-0.445
CDC14A	-0.442
CCDC121	-0.436
KIAA0754	-0.433
REST	-0.427
ZIC5	-0.424

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB06404	Human C1-esterase inhibitor	BiotechDrug		Approved	Target
DB06689	Ethanolamine Oleate	Small Molecule	2272-11-9	Approved	Target
DB09228	Conestat alfa	BiotechDrug	80295-38-1	Approved\|Investigational	Target
DB12598	Nafamostat	Small Molecule	81525-10-2	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of F12 mRNA"	20453058
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of F12 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of F12 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F12 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F12 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of F12 mRNA	26690555\|2906747
D020106	Acrylamide	Acrylamide results in increased expression of F12 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of F12 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of F12 mRNA	27153756
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in decreased expression of F12 protein	6383834
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of F12 mRNA	24449571
C006632	arsenic trioxide	F12 protein results in decreased susceptibility to arsenic trioxide	20707922
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F12 mRNA	20064835
C006780	bisphenol A	bisphenol A results in decreased expression of F12 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of F12 mRNA	18958704
C018475	butyraldehyde	butyraldehyde results in increased expression of F12 mRNA	26079696
D002104	Cadmium	F12 protein binds to Cadmium	23896426
D002809	Chondroitin Sulfates	Chondroitin Sulfates analog results in increased activity of F12 protein	18434646
D002994	Clofibrate	Clofibrate results in decreased expression of F12 mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of F12 mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of F12 mRNA	24386269
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of F12 mRNA	20971185
D003471	Cuprizone	Cuprizone results in decreased expression of F12 mRNA	26577399
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA]	11007951
D016572	Cyclosporine	Cyclosporine results in decreased expression of F12 mRNA	20106945\|2556210
C014347	decitabine	decitabine affects the expression of F12 mRNA	23300844
D002945	Cisplatin	Cisplatin affects the expression of F12 mRNA	23300844
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of F12 mRNA	19041683
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA	24690739
C035276	eicosapentaenoic acid ethyl ester	eicosapentaenoic acid ethyl ester results in decreased activity of F12 protein	14614217
D004610	Ellagic Acid	ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]	6343536
D004610	Ellagic Acid	Ellagic Acid results in increased activity of F12 protein	6343536
C118739	entinostat	entinostat results in increased expression of F12 mRNA	27188386
D005472	Fluorouracil	F12 protein affects the susceptibility to Fluorouracil	15352031
D005472	Fluorouracil	Fluorouracil results in decreased expression of F12 protein	15352031
D005485	Flutamide	Flutamide results in decreased expression of F12 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in decreased expression of F12 mRNA	19167457
C039281	furan	furan results in decreased expression of F12 mRNA	25539665
C039281	furan	furan results in increased methylation of F12 gene	22079235
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of F12 mRNA	17183730
C492448	ICG 001	ICG 001 results in increased expression of F12 mRNA	26191083
D007529	Isoflavones	Isoflavones affects the expression of F12 mRNA	16365062
C544151	jinfukang	jinfukang results in increased expression of F12 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of F12 mRNA	23430699\|2675264
C410337	K 7174	K 7174 results in decreased expression of F12 mRNA	24086573
D007616	Kaolin	Kaolin results in increased activity of F12 protein	6343536
D008727	Methotrexate	F12 protein affects the susceptibility to Methotrexate	16217747
D009532	Nickel	F12 protein binds to Nickel	23896426
D009532	Nickel	Nickel results in increased expression of F12 mRNA	25583101
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of F12 mRNA	20971185
D052638	Particulate Matter	Particulate Matter results in increased expression of F12 protein	17520064
C046012	pentanal	pentanal results in increased expression of F12 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of F12 mRNA	20936131
D011122	Polyphosphates	F12 gene mutant form results in decreased susceptibility to Polyphosphates	25339356
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of F12 mRNA	24780913
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased activity of F12 protein	16359964
C089730	rosiglitazone	rosiglitazone results in decreased expression of F12 mRNA	25572481
D012524	Sarin	Sarin results in decreased expression of F12 mRNA	19522546
D013433	Sulfoglycosphingolipids	ALB protein promotes the reaction [Sulfoglycosphingolipids results in increased activity of F12 protein]	6343536
D013433	Sulfoglycosphingolipids	Sulfoglycosphingolipids results in increased activity of F12 protein	6343536
D013433	Sulfoglycosphingolipids	Sulfoglycosphingolipids results in increased cleavage of F12 protein	6343536
D013739	Testosterone	Testosterone results in decreased expression of F12 mRNA	19693291
D013739	Testosterone	Testosterone results in increased expression of F12 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of F12 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA	21215274
D013849	Thimerosal	Thimerosal results in decreased expression of F12 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in decreased expression of F12 mRNA	23411599
D014520	Urethane	Urethane results in decreased expression of F12 mRNA	28818685
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of F12 mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F12 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of F12 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of F12 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of F12 mRNA	26272509\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of F12 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of F12 protein	17520064
D015032	Zinc	F12 protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	IBA	21873635
GO:0004252	serine-type endopeptidase activity	-	IDA	6793628 18725990
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005509	calcium ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	8710908 21304106
GO:0051787	misfolded protein binding	-	IC	18725990

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002353	plasma kallikrein-kinin cascade	-	IDA	6793628 18725990
GO:0002542	Factor XII activation	-	IDA	18725990
GO:0006508	proteolysis	-	IBA	21873635
GO:0007597	blood coagulation, intrinsic pathway	-	IC	18725990
GO:0007597	blood coagulation, intrinsic pathway	-	TAS	-
GO:0010756	positive regulation of plasminogen activation	-	IDA	89876
GO:0016485	protein processing	-	IDA	18725990
GO:0016540	protein autoprocessing	-	IDA	18725990
GO:0030194	positive regulation of blood coagulation	-	IDA	6793628
GO:0031638	zymogen activation	-	IDA	89876 6793628 18725990
GO:0042730	fibrinolysis	-	IEA	-
GO:0045087	innate immune response	-	TAS	2510163
GO:0051788	response to misfolded protein	-	IDA	18725990
GO:0051919	positive regulation of fibrinolysis	-	IDA	89876

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	6793628
GO:0005791	rough endoplasmic reticulum	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27161691	PO-04 - A new genetic risk score for predicting venous thromboembolic events in cancer patients receiving chemotherapy. (2016 Apr)	Martin AJ	Thromb Res