Gene info: ID 2162

Gene: F13A1

GENE ID: 2162

Synonyms: F13A

Description: coagulation factor XIII A chain

Gene type: protein-coding

Location: 6p25.1

dbXrefs: Ensembl:ENSG00000124491 MIM:134570 Vega:OTTHUMG00000014186 UniprotKB:P00488

RefSeq: NG_008107.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.156e-1 (AD) 4.704e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RGS18	0.792
MS4A4A	0.769
KCNE3	0.767
FCGR2B	0.767
HLA-DMB	0.764
TLR7	0.762
MS4A6A	0.76
CTSC	0.758
CYBB	0.758
PLCG2	0.757

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES6	-0.424
WIF1	-0.396
ARSF	-0.363
WNT7B	-0.354
HAGHL	-0.346
C9orf24	-0.335
SLC25A48	-0.329
HES5	-0.324
HPDL	-0.324
SLC13A5	-0.322

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01839	Propylene glycol	Small Molecule	57-55-6	Approved\|Investigational	Target
DB02340	N-Acetyl-Serine	Small Molecule	16354-58-8	Experimental	Target
DB11311	Prothrombin	BiotechDrug	9001-26-7	Approved	Target
DB13151	Anti-inhibitor coagulant complex	BiotechDrug		Approved\|Investigational	Target
DB00130	L-Glutamine	Small Molecule	56-85-9	Approved\|Investigational\|Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of F13A1 mRNA"	27291303
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F13A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F13A1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of F13A1 mRNA	17562736
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of F13A1 mRNA	22129741
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of F13A1 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of F13A1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of F13A1 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of F13A1 mRNA	20458559
C487081	belinostat	belinostat results in increased expression of F13A1 mRNA	27188386
D001554	Benzene	Benzene results in decreased expression of F13A1 mRNA	19162166
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of F13A1 mRNA	26377693
D004958	Estradiol	Estradiol affects the expression of F13A1 mRNA	14699072
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of F13A1 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of F13A1 mRNA	17404688
D004958	Estradiol	Estradiol results in increased expression of F13A1 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of F13A1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of F13A1 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of F13A1 mRNA	17582521
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of F13A1 mRNA	27339419
D002737	Chloroprene	Chloroprene results in increased expression of F13A1 mRNA	23125180
C031180	chrysene	chrysene results in increased expression of F13A1 mRNA	26377693
D003033	Coal Tar	Coal Tar results in increased expression of F13A1 mRNA	27858113
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of F13A1 mRNA	23640034
D004008	Diclofenac	Diclofenac results in increased expression of F13A1 mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in decreased expression of F13A1 mRNA	18042831
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of F13A1 mRNA	22129741
D002117	Calcitriol	Calcitriol results in decreased expression of F13A1 mRNA	26485663
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of F13A1 mRNA	17374397
D004237	Diuron	Diuron results in decreased expression of F13A1 mRNA	25152437
D005054	Eugenol	Eugenol results in decreased expression of F13A1 mRNA	17374397
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of F13A1 mRNA	20846436
D017313	Fenretinide	Fenretinide results in decreased expression of F13A1 mRNA	28973697
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of F13A1 mRNA	22129741
D007460	Iodoacetamide	Iodoacetamide results in decreased activity of F13A1 protein	15618543
D007501	Iron	Iron deficiency results in decreased expression of F13A1 mRNA	20368581
D007545	Isoproterenol	Isoproterenol results in increased expression of F13A1 mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of F13A1 mRNA	26752646
C008261	lead acetate	lead acetate results in increased expression of F13A1 mRNA	27562236
C018091	maduramicin	maduramicin results in decreased expression of F13A1 mRNA	29128925
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of F13A1 mRNA	26378955
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of F13A1 mRNA	20843944
D015122	Mercaptopurine	Mercaptopurine results in increased expression of F13A1 mRNA	23358152
D008727	Methotrexate	Methotrexate results in decreased expression of F13A1 mRNA	24449571
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of F13A1 promoter"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of F13A1 mRNA"	26251327
D015735	Mifepristone	Mifepristone results in increased expression of F13A1 mRNA	17584828
C523799	MRK 003	F13A1 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of F13A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of F13A1 mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	F13A1 protein affects the susceptibility to 1-Naphthylisothiocyanate	26921287
C029938	nickel sulfate	nickel sulfate results in decreased expression of F13A1 mRNA	16780908\|1737439
D010081	Oxazolone	Oxazolone results in decreased expression of F13A1 mRNA	17374397
D017239	Paclitaxel	Paclitaxel results in increased expression of F13A1 mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of F13A1 mRNA	18042831
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of F13A1 mRNA	26705709
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F13A1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of F13A1 mRNA	26272509
D017035	Pravastatin	Pravastatin results in decreased expression of F13A1 mRNA	27225895
D017035	Pravastatin	Pravastatin results in decreased expression of F13A1 mRNA	27225895
D011374	Progesterone	Progesterone results in decreased expression of F13A1 mRNA	23012394
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of F13A1 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of F13A1 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of F13A1 mRNA	19690047
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of F13A1 mRNA	14699072
C059514	resveratrol	resveratrol results in increased expression of F13A1 mRNA	25280562
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of F13A1 mRNA	23221170
D053260	Soot	Soot results in decreased expression of F13A1 mRNA	26551751
C075117	squalestatin 1	squalestatin 1 affects the expression of F13A1 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 affects the expression of F13A1 mRNA	27225895
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of F13A1 mRNA	26378955
C016766	sulforafan	sulforafan results in decreased expression of F13A1 mRNA	26833863
D013629	Tamoxifen	ESR2 protein affects the reaction [Tamoxifen results in decreased expression of F13A1 mRNA]	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of F13A1 mRNA	14699072
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of F13A1 mRNA	16443690\|1788433
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F13A1 mRNA	17884332
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of F13A1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F13A1 mRNA	26232522
C009495	titanium dioxide	titanium dioxide results in increased expression of F13A1 mRNA	23557971
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of F13A1 mRNA	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of F13A1 mRNA	20133372
D014212	Tretinoin	Tretinoin results in decreased expression of F13A1 mRNA	23724009
C011559	tributyltin	tributyltin results in increased expression of F13A1 mRNA	21683754
C012589	trichostatin A	trichostatin A results in decreased expression of F13A1 mRNA	15901671
C057693	troglitazone	troglitazone results in increased expression of F13A1 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased expression of F13A1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of F13A1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of F13A1 protein	12859294
D014635	Valproic Acid	Valproic Acid results in increased expression of F13A1 mRNA	23179753
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of F13A1 gene	25560391
D014807	Vitamin D	Vitamin D affects the expression of F13A1 mRNA	20368581
C111237	vorinostat	vorinostat results in increased expression of F13A1 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	-	IDA	27363989
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	-	TAS	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002576	platelet degranulation	-	TAS	-
GO:0007596	blood coagulation	-	TAS	-
GO:0018149	peptide cross-linking	-	IDA	27363989
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0072378	blood coagulation, fibrin clot formation	-	IDA	27363989

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0031093	platelet alpha granule lumen	-	TAS	-
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-140875	Common Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS
R-HSA-168256	Immune System	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28978253	Coagulation F13A1 V34L, fibrinogen and homocysteine versus conventional risk factors in the pathogenesis of MI in young persons. (2017 Oct 5)	Vishwajeet V	Acta Cardiol