Gene: F13B

2165
FXIIIB
coagulation factor XIII B chain
protein-coding
1q31.3
Ensembl:ENSG00000143278 MIM:134580 Vega:OTTHUMG00000036519 UniprotKB:P05160
NG_012065.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.478e-2 (AD)  7.854e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR10K20.85
OR6C20.844
OR5H20.839
OR4X10.831
ADAM300.824
POTEA0.822
OR4K20.821
PRAMEF20.819
HIST1H2AA0.816
OR10H40.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT1-0.267
FUT9-0.263
ACSL6-0.25
DBP-0.24
ABCD2-0.239
SLC1A4-0.239
HSPB2-0.237
C1orf53-0.237
PIH1D2-0.236
EFNA5-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of F13B mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of F13B mRNA28522335
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of F13B protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of F13B mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of F13B mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of F13B mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F13B mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of F13B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of F13B mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of F13B gene27153756
D000447AldehydesAldehydes results in decreased expression of F13B mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of F13B mRNA28522335
D001104ArbutinArbutin results in decreased expression of F13B mRNA17103032
C547126AZM551248AZM551248 results in increased expression of F13B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of F13B gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of F13B mRNA19770486
D004958EstradiolEstradiol results in decreased expression of F13B mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of F13B mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of F13B mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of F13B mRNA27339419
D002509CephaloridineCephaloridine results in decreased expression of F13B mRNA18500788
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of F13B mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of F13B mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F13B mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of F13B mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of F13B mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of F13B mRNA19770486|2383089
D002117CalcitriolCalcitriol results in increased expression of F13B mRNA16002434
C016517indole-3-carbinolindole-3-carbinol affects the expression of F13B mRNA21396975
C046012pentanalpentanal results in decreased expression of F13B mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of F13B mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of F13B mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of F13B mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of F13B mRNA19429403
D011374ProgesteroneProgesterone results in increased expression of F13B mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of F13B mRNA26079696
D012293RifampinRifampin results in increased expression of F13B mRNA24552687
C017947sodium arsenitesodium arsenite affects the expression of F13B mRNA20451245
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of F13B mRNA15703262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of F13B mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of F13B mRNA21724226
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of F13B gene27618143
D014520UrethaneUrethane results in decreased expression of F13B mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of F13B mRNA29154799
D014640VancomycinVancomycin results in increased expression of F13B mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of F13B gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of F13B mRNA26682919
D015032ZincF13B protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21807600Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)Hageman GSHum Genomics
26218915Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. (2015 Jul)Keenan TDInvest Ophthalmol Vis Sci
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet