Gene: FABP2

2169
FABPI|I-FABP
fatty acid binding protein 2
protein-coding
4q26
Ensembl:ENSG00000145384 MIM:134640 Vega:OTTHUMG00000132972 UniprotKB:P12104
NG_011444.1
PubMed
0   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.845e-1 (AD)  9.462e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5D130.654
CYLC10.632
OR51V10.624
KRTAP15-10.619
HIST1H2AA0.604
OR2W10.603
OR10H40.603
OR4X10.601
LRRC300.6
OR5H20.598

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.241
IQCD-0.237
SLC25A48-0.225
HSD17B6-0.222
CDH20-0.218
LRP4-0.216
NPFFR1-0.211
FXYD3-0.208
ACOT6-0.207
ADARB2-0.207

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalCarrier
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedCarrier
DB03796Palmitic AcidSmall Molecule57-10-3Approved|ExperimentalCarrier
DB04557Arachidonic AcidSmall Molecule506-32-1ExperimentalCarrier
DB08231Myristic acidSmall Molecule544-63-8ExperimentalCarrier
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalCarrier
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalCarrier
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalCarrier
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalCarrier
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FABP2 mRNA"28903501
C00202917alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FABP2 mRNA"17275934
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FABP2 mRNA"27291303
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of FABP2 mRNA"21920950
C0164032,4-dinitrotoluene"2,4-dinitrotoluene results in decreased expression of FABP2 mRNA"24893713
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FABP2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FABP2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FABP2 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of FABP2 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FABP2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FABP2 mRNA19770486|2171566
C095105bexarotenebexarotene results in decreased expression of FABP2 mRNA17630414
C095105bexarotene[Tamoxifen co-treated with bexarotene] results in decreased expression of FABP2 mRNA17630414
D001629BezafibrateBezafibrate results in increased expression of FABP2 mRNA17118139
C006780bisphenol Abisphenol A affects the expression of FABP2 mRNA21786754
D002136Calcium, Dietary"Calcium, Dietary results in decreased expression of FABP2 mRNA"15539406
D002136Calcium, Dietary"[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA"15539406
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of FABP2 mRNA18636392
D002994ClofibrateClofibrate results in increased expression of FABP2 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of FABP2 mRNA19549813
D003314Corn OilCorn Oil affects the expression of FABP2 mRNA16360708
C029892cupric chloridecupric chloride results in increased expression of FABP2 mRNA21072851
C057862cyanoginosin LRcyanoginosin LR results in increased expression of FABP2 protein26984711
D016572CyclosporineCyclosporine results in decreased expression of FABP2 mRNA19770486
C093628cyproconazolecyproconazole affects the expression of FABP2 mRNA21621602
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FABP2 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FABP2 mRNA]27941970
D004008DiclofenacDiclofenac results in decreased expression of FABP2 mRNA26934552
D004008DiclofenacDiclofenac results in decreased expression of FABP2 mRNA19022234
D004041Dietary FatsDietary Fats affects the expression of FABP2 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FABP2 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of FABP2 mRNA15238619|1635704
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of FABP2 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of FABP2 mRNA28085963
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of FABP2 mRNA19245819|1985064
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of FABP2 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FABP2 mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of FABP2 mRNA12655031
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of FABP2 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FABP2 mRNA17606305
C034096ethoxyacetic acidethoxyacetic acid affects the expression of FABP2 mRNA21621602
D011345FenofibrateFenofibrate results in increased expression of FABP2 mRNA17118139
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of FABP2 mRNA17347304
C061365flusilazoleflusilazole affects the expression of FABP2 mRNA21621602
C039281furanfuran results in increased expression of FABP2 mRNA25539665|2619464
D006418Heme"[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA"15539406
D006418HemeHeme results in increased expression of FABP2 mRNA15539406
D007501IronIron deficiency results in increased expression of FABP2 mRNA19821111
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FABP2 mRNA26752646
D008687MetforminMetformin results in decreased expression of FABP2 mRNA19022234
D008713MethimazoleMethimazole results in decreased expression of FABP2 mRNA17403546
C013598methoxyacetic acidmethoxyacetic acid affects the expression of FABP2 mRNA21621602
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of FABP2 mRNA16966085
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FABP2 mRNA24767308
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of FABP2 mRNA24128854
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of FABP2 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FABP2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FABP2 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FABP2 mRNA25380136
D019301Oleic AcidFABP2 protein modified form binds to Oleic Acid16137630
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of FABP2 mRNA18636392
D000073878Palm OilPalm Oil affects the expression of FABP2 mRNA19680557
D010269Paraquat"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FABP2 mRNA"17275934
C494474perchlorateperchlorate results in decreased expression of FABP2 mRNA17403546
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of FABP2 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FABP2 mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FABP2 mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of FABP2 mRNA]18467677
D010634PhenobarbitalPhenobarbital affects the expression of FABP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of FABP2 mRNA25270620
D010634PhenobarbitalPhenobarbital results in increased expression of FABP2 mRNA19162173
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of FABP2 mRNA21621602
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FABP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of FABP2 mRNA16221962|1635704
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of FABP2 mRNA]18467677|2005976
D059808PolyphenolsPolyphenols results in decreased expression of FABP2 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of FABP2 mRNA23608068
D017035PravastatinPravastatin results in decreased expression of FABP2 mRNA27225895
D017035PravastatinPravastatin results in increased expression of FABP2 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FABP2 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of FABP2 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of FABP2 mRNA17403546
C042734rifaximin[NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of FABP2 protein22790967
C541923sandostatinLARsandostatinLAR results in increased expression of FABP2 mRNA17210224
C009277sodium arsenatesodium arsenate results in decreased expression of FABP2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of FABP2 protein23570992
C016104sodium bichromatesodium bichromate results in decreased expression of FABP2 mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of FABP2 mRNA25993096
D014284TriiodothyronineTriiodothyronine results in increased expression of FABP2 mRNA17403546
D016559TacrolimusTacrolimus results in decreased expression of FABP2 mRNA25270620
C013698tallowtallow affects the expression of FABP2 mRNA19680557
D013629Tamoxifen[Tamoxifen co-treated with bexarotene] results in decreased expression of FABP2 mRNA17630414
D013629TamoxifenTamoxifen results in decreased expression of FABP2 mRNA17630414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FABP2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FABP2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FABP2 mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FABP2 mRNA19770486
D013749Tetrachlorodibenzodioxin"[17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol co-treated with Paraquat co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FABP2 mRNA"17275934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FABP2 mRNA17275934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FABP2 mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of FABP2 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of FABP2 mRNA23411599
D014212TretinoinTretinoin affects the expression of FABP2 mRNA18230668
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of FABP2 mRNA17982090
D014303TrinitrotolueneTrinitrotoluene affects the expression of FABP2 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FABP2 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of FABP2 mRNA19022234
D014635Valproic AcidFABP2 gene SNP affects the susceptibility to Valproic Acid17310796
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FABP2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FABP2 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of FABP2 mRNA"22326570
D015032ZincZinc deficiency results in increased expression of FABP2 mRNA11717422

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005504fatty acid binding-TAS2824476  
GO:0005515protein binding-IPI21044950  25416956  25910212  
GO:0036041long-chain fatty acid binding-IDA7883976  
GO ID GO Term Qualifier Evidence PubMed
GO:0019433triglyceride catabolic process-TAS-  
GO:0098856intestinal lipid absorption-IMP7883976  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-163560Triglyceride catabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8979227Triglyceride metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11730822Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in the Framingham Offspring Study. (2001 Dec)Galluzzi JRAtherosclerosis
10597471Parental sex effect in families with alcoholism. (1999)Wyszynski DFGenet Epidemiol
21432258Genetic and environmental factors affecting peak bone mass in premenopausal Japanese women. (2001 Oct)Hayakawa YEnviron Health Prev Med
15135268Genetic risk for restenosis after coronary balloon angioplasty. (2004 May)Horibe HAtherosclerosis
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res
10597410Mapping alcoholism genes using linkage/linkage disequilibrium analysis. (1999)Aragaki CGenet Epidemiol
22038464Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content. (2012 Oct)Barth SWEur J Nutr
16013194Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis. (2005 May)Wanby PVasc Med
16451575Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data. (2005 Dec 30)Zhang HBMC Genet
11423496Association of the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the Framingham Offspring Study. (2001 Jul)Galluzzi JRDiabetes Care
15527447The FABP2 gene polymorphism in cerebrovascular disease. (2004 Dec)Wanby PActa Neurol Scand