Gene: FANCA

2175
FA|FA-H|FA1|FAA|FACA|FAH|FANCH
FA complementation group A
protein-coding
16q24.3
Ensembl:ENSG00000187741 MIM:607139 Vega:OTTHUMG00000173049 UniprotKB:O15360
NG_011706.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.850e-1 (AD)  1.945e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1B0.911
DRP20.91
DEPDC50.907
TMEM2410.906
FSTL40.901
POLR3A0.9
AACS0.897
FOCAD0.895
EML60.894
PPIP5K10.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.572
HEY2-0.548
RAB13-0.536
MYL3-0.525
AKR1C3-0.516
COPZ2-0.515
ROM1-0.511
MBNL3-0.507
GNG12-0.506
TMEM176A-0.502

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FANCA mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of FANCA mRNA"19934314
D000082AcetaminophenAcetaminophen results in increased expression of FANCA mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of FANCA mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of FANCA mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FANCA mRNA22100608
D000447AldehydesFANCA gene mutant form results in increased susceptibility to Aldehydes25155611
D000638AmiodaroneAmiodarone results in increased expression of FANCA mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FANCA mRNA24449571
D001151ArsenicArsenic affects the methylation of FANCA gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FANCA mRNA20458559
C015001arsenitearsenite results in decreased expression of FANCA mRNA18929588
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FANCA gene25435355
C006780bisphenol Abisphenol A results in decreased expression of FANCA mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of FANCA mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FANCA mRNA20938992
C074702chromium hexavalent ionFANCA protein results in increased susceptibility to chromium hexavalent ion12426130
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FANCA mRNA20971185
D003300CopperCopper deficiency results in increased expression of FANCA mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of FANCA mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FANCA mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of FANCA mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of FANCA mRNA21878529
D000069439DasatinibDasatinib results in decreased expression of FANCA mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FANCA mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FANCA mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FANCA mRNA26924002
D004041Dietary FatsFANCA gene mutant form results in increased susceptibility to Dietary Fats22482891
D002117CalcitriolCalcitriol results in decreased expression of FANCA mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FANCA mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of FANCA mRNA26924002
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FANCA mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FANCA mRNA20938992
C039281furanfuran results in increased expression of FANCA mRNA25539665
D017313FenretinideFenretinide results in increased expression of FANCA mRNA28973697
D006861Hydrogen PeroxideFANCA protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of INSR protein]22482891
C544151jinfukangjinfukang results in increased expression of FANCA mRNA27392435
D007854LeadLead affects the expression of FANCA mRNA28903495
C008261lead acetatelead acetate results in decreased expression of FANCA mRNA22609695
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FANCA mRNA20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of FANCA mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FANCA mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FANCA mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FANCA mRNA"25554681
D009532NickelNickel results in increased expression of FANCA mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of FANCA mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FANCA mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of FANCA mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCA mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of FANCA mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of FANCA mRNA23091169
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of FANCA mRNA]17950772
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of FANCA mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FANCA mRNA17950772
C006253pirinixic acidpirinixic acid results in increased expression of FANCA mRNA20813756|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of FANCA mRNA]17950772
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of FANCA mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FANCA mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FANCA mRNA22698814
D011372ProgestinsProgestins results in decreased expression of FANCA mRNA19609016
D011441PropylthiouracilPropylthiouracil results in decreased expression of FANCA mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FANCA mRNA19167446
D012402RotenoneRotenone results in increased expression of FANCA mRNA18191903
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FANCA mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FANCA mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of FANCA gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of FANCA mRNA28595984
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of FANCA mRNA"26680231
D013629TamoxifenTamoxifen results in increased expression of FANCA mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FANCA mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FANCA mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FANCA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FANCA gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FANCA mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FANCA mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of FANCA mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of FANCA mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FANCA mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FANCA mRNA"26179874
D014520UrethaneUrethane results in decreased expression of FANCA mRNA28818685
D014638VanadatesVanadates results in decreased expression of FANCA mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FANCA gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of FANCA mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9742112  10373536  10468606  10627486  10652215  11063725  
11157805  11726552  12354784  12571280  12649160  16189514  
17289582  17396147  17474147  21240188  22266823  22343915  
22705371  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-TAS8896564  
GO:0007140male meiotic nuclear division-IEA-  
GO:0008584male gonad development-IEA-  
GO:0008585female gonad development-IEA-  
GO:0036297interstrand cross-link repair-TAS-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0045589regulation of regulatory T cell differentiation-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0051090regulation of DNA-binding transcription factor activity-IEA-  
GO:0065003protein-containing complex assembly-TAS9398857  
GO:2000348regulation of CD40 signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11726552  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0043240Fanconi anaemia nuclear complex-IDA20347428  22266823  22343915  22705371  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal