Gene: FANCC

2176
FA3|FAC|FACC
FA complementation group C
protein-coding
9q22.32
Ensembl:ENSG00000158169 MIM:613899 Vega:OTTHUMG00000020279 UniprotKB:Q00597
NG_011707.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.802e-1 (AD)  3.125e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNA20.729
SNRNP480.71
SLC38A20.691
TOP3B0.687
ZNF37A0.687
TIMELESS0.686
CCNA20.68
RAD520.678
MTRF10.676
CASP20.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU-0.429
HPDL-0.374
DIO2-0.368
ACBD7-0.348
CRH-0.347
FBXL22-0.331
HES5-0.331
REN-0.324
BTBD17-0.321
ROPN1B-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FANCC mRNA"27291303
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of FANCC mRNA"19934314
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FANCC mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FANCC mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FANCC mRNA24449571
D001151ArsenicArsenic affects the methylation of FANCC gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FANCC mRNA15070760
D001280AtrazineAtrazine results in increased expression of FANCC mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FANCC mRNA22316170|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FANCC mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of FANCC mRNA16705744
C006780bisphenol Abisphenol A affects the expression of FANCC mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FANCC mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of FANCC mRNA24752500
D002330CarmustineFANCC mRNA affects the susceptibility to Carmustine16365179
D002699ChlorambucilFANCC protein results in increased susceptibility to Chlorambucil16243825
C017160cypermethrincypermethrin results in increased expression of FANCC mRNA21142847
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FANCC mRNA23640034
C014347decitabinedecitabine affects the expression of FANCC mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FANCC mRNA21266533
D002945CisplatinCisplatin affects the expression of FANCC mRNA23300844
D002945CisplatinCisplatin results in decreased expression of FANCC mRNA19561079|2153299
D002945CisplatinFANCC protein results in decreased susceptibility to Cisplatin21115814
D002945CisplatinFANCC protein results in increased susceptibility to Cisplatin16243825
D002945CisplatinCisplatin results in decreased expression of FANCC mRNA24865317
D004008DiclofenacDiclofenac affects the expression of FANCC mRNA24752500
D004026DieldrinDieldrin results in decreased expression of FANCC mRNA23041725
D004041Dietary FatsFANCC gene mutant form results in increased susceptibility to Dietary Fats22482891
D002117CalcitriolCalcitriol results in decreased expression of FANCC mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FANCC mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FANCC mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FANCC mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FANCC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FANCC mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FANCC mRNA27776689
D005472FluorouracilFluorouracil results in decreased expression of FANCC mRNA16557594
D005557FormaldehydeFANCC gene mutant form results in increased susceptibility to Formaldehyde18056434
D019833GenisteinGenistein results in decreased expression of FANCC mRNA16705744
D006861Hydrogen PeroxideFANCC protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of INSR protein]22482891
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FANCC mRNA12057914
C015329lycopenelycopene results in decreased expression of FANCC mRNA16886892
D008558MelphalanFANCC protein results in increased susceptibility to Melphalan16243825
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FANCC mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of FANCC mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FANCC mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FANCC mRNA"25554681
C025589ochratoxin Aochratoxin A results in decreased expression of FANCC mRNA23358140
D010416PentachlorophenolPentachlorophenol results in increased expression of FANCC mRNA23892564
C030090phosphoramide mustardphosphoramide mustard results in increased expression of FANCC mRNA26708502
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FANCC mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FANCC mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FANCC mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of FANCC mRNA23012394
D012402RotenoneRotenone results in increased expression of FANCC mRNA18191903
D012822Silicon DioxideSilicon Dioxide results in increased expression of FANCC mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of FANCC mRNA16014739
D013629TamoxifenTamoxifen affects the expression of FANCC mRNA17555576
C047246temozolomideFANCC mRNA affects the susceptibility to temozolomide16365179
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FANCC mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FANCC mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of FANCC mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FANCC mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FANCC mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FANCC mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FANCC mRNA17942748
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FANCC mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of FANCC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FANCC mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FANCC gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9596688  9742112  10551855  10627486  11157805  12093742  
12649160  19102630  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0002262myeloid cell homeostasis-IEA-  
GO:0006281DNA repair-TAS1574115  
GO:0006289nucleotide-excision repair-IBA21873635  
GO:0007281germ cell development-IEA-  
GO:0019430removal of superoxide radicals-IEA-  
GO:0034599cellular response to oxidative stress-IBA21873635  
GO:0036297interstrand cross-link repair-TAS-  
GO:0048854brain morphogenesis-IEA-  
GO:0065003protein-containing complex assembly-TAS9398857  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9398857  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS9398857  
GO:0005829cytosol-IDA9596688  
GO:0043240Fanconi anaemia nuclear complex-IBA21873635  
GO:0043240Fanconi anaemia nuclear complex-IDA20347428  22266823  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26842001Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility. (2016 Feb 3)Yang SYJ Biomed Sci