Gene: FANCD2

2177
FA-D2|FA4|FACD|FAD|FAD2|FANCD
FA complementation group D2
protein-coding
3p25.3
Ensembl:ENSG00000144554 MIM:613984 Vega:OTTHUMG00000128670 UniprotKB:Q9BXW9
NG_007311.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.135e-1 (AD)  2.653e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KNTC10.779
PIGL0.762
WDR110.762
ALG90.753
NHLRC30.752
PLAG10.749
CCDC140.746
TTC130.744
TUBGCP30.742
ALG130.741

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7B-0.465
LYPD1-0.407
BTBD17-0.397
PYGM-0.393
EYA2-0.393
S100A1-0.386
PPP1R3G-0.379
NWD1-0.371
SLC22A6-0.368
DIO2-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased ubiquitination of FANCD2 protein26208482
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FANCD2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of FANCD2 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FANCD2 mRNA"23196670
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of FANCD2 mRNA"19934314
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA19191707
D000079AcetaldehydeFANCD2 gene mutant form results in increased susceptibility to Acetaldehyde18056434
D000079AcetaldehydeAcetaldehyde results in increased expression of FANCD2 protein18482162
D000082AcetaminophenAcetaminophen results in decreased expression of FANCD2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of FANCD2 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of FANCD2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FANCD2 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FANCD2 mRNA24449571
C006632arsenic trioxide[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to erythritol anhydride25092648
C006632arsenic trioxide[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea25092648
C006632arsenic trioxide[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin25092648
C547126AZM551248AZM551248 results in increased expression of FANCD2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FANCD2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FANCD2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FANCD2 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of FANCD2 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of FANCD2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FANCD2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of FANCD2 mRNA25181051|2698221
D000069286BortezomibBortezomib results in decreased expression of FANCD2 mRNA19934314|2191775
D000069286BortezomibBortezomib results in decreased expression of FANCD2 protein19934314
C018475butyraldehydebutyraldehyde results in decreased expression of FANCD2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FANCD2 mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of FANCD2 mRNA25979313
D002330CarmustineCarmustine affects the localization of FANCD2 protein17221219
D002330CarmustineCarmustine results in increased ubiquitination of FANCD2 protein17221219
D002509CephaloridineCephaloridine results in increased expression of FANCD2 mRNA18500788
C074702chromium hexavalent ionchromium hexavalent ion results in increased ubiquitination of and results in increased activity of FANCD2 protein16893675
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FANCD2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FANCD2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FANCD2 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of FANCD2 mRNA21878529
C029892cupric chloridecupric chloride results in decreased expression of FANCD2 mRNA24650576
D003474CurcuminCurcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D003474CurcuminCurcumin results in decreased expression of FANCD2 mRNA24124520
D016572CyclosporineCyclosporine results in decreased expression of FANCD2 mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of FANCD2 mRNA20579391
D002945CisplatinCisplatin results in increased expression of FANCD2 mRNA27594783
D002945CisplatinCisplatin results in increased ubiquitination of FANCD2 protein21324906
D004074DigitoxinDigitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D004077DigoxinDigoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D002117CalcitriolCalcitriol results in decreased expression of FANCD2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FANCD2 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of FANCD2 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of FANCD2 mRNA]27181935
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FANCD2 protein23301498
C007366erythritol anhydride[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to erythritol anhydride25092648
C007366erythritol anhydride[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to erythritol anhydride25092648
D000431EthanolEthanol results in increased expression of FANCD2 mRNA18482162
D000431EthanolEthanol results in increased expression of FANCD2 protein18482162
D000431EthanolEthanol results in increased expression of FANCD2 mRNA18482162
D000431EthanolEthanol results in increased expression of FANCD2 protein18482162
D005485FlutamideFlutamide results in increased expression of FANCD2 mRNA24793618
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of FANCD2 mRNA24657277
D005557FormaldehydeFANCD2 gene mutant form results in increased susceptibility to Formaldehyde18056434
D005557FormaldehydeFormaldehyde results in decreased expression of FANCD2 mRNA23649840
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of FANCD2 mRNA]27181935
C039281furanfuran results in increased expression of FANCD2 mRNA25539665
D006918Hydroxyurea[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea25092648
D006918Hydroxyurea[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea25092648
C544151jinfukangjinfukang results in increased expression of FANCD2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FANCD2 mRNA24796395
D007854LeadLead affects the expression of FANCD2 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of FANCD2 mRNA28988120
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of FANCD2 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of FANCD2 mRNA24657277
D016685Mitomycin[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin25092648
D016685MitomycinCurcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D016685MitomycinDigitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D016685MitomycinDigoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D016685MitomycinMitomycin results in increased expression of and results in increased ubiquitination of FANCD2 protein24124520
D016685MitomycinMitomycin results in increased ubiquitination of FANCD2 protein26208482
D016685Mitomycin[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin25092648
D016685MitomycinOuabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D016685MitomycinSB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]24124520
C020300monomethylarsonic acid[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to erythritol anhydride25092648
C020300monomethylarsonic acid[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Hydroxyurea25092648
C020300monomethylarsonic acid[monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin25092648
D009151Mustard GasMustard Gas results in decreased expression of FANCD2 mRNA25102026
C022838nickel chloridenickel chloride results in decreased expression of FANCD2 mRNA28472268
C022838nickel chloridenickel chloride results in decreased expression of FANCD2 protein28472268
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in increased expression of FANCD2 mRNA27342729
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in increased expression of FANCD2 protein27342729
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FANCD2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of FANCD2 mRNA26516004
D010100OxygenOxygen deficiency results in decreased expression of FANCD2 protein28472268
D010126OzoneOzone results in decreased expression of FANCD2 mRNA24336422
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FANCD2 mRNA"25510870
C046012pentanalpentanal results in decreased expression of FANCD2 mRNA26079696
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of FANCD2 mRNA26678675
D010936Plant ExtractsPlant Extracts results in increased expression of FANCD2 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of FANCD2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FANCD2 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FANCD2 mRNA19167446
C059514resveratrolresveratrol results in decreased susceptibility to FANCD2 gene mutant form22628295
D012402RotenoneRotenone results in increased expression of FANCD2 mRNA18191903
C093642SB 203580SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]24124520
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FANCD2 mRNA25895662
D010042OuabainOuabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]24124520
D010042OuabainOuabain results in decreased expression of FANCD2 mRNA24124520
D010042OuabainSB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]24124520
C047246temozolomidetemozolomide affects the localization of FANCD2 protein17221219
C047246temozolomidetemozolomide results in increased ubiquitination of FANCD2 protein17221219
C001803tempoltempol results in decreased susceptibility to FANCD2 gene mutant form22628295
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FANCD2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FANCD2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FANCD2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FANCD2 mRNA19465110
D013853ThioacetamideThioacetamide results in increased expression of FANCD2 mRNA22659510
D013893ThiramThiram results in decreased expression of FANCD2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of FANCD2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FANCD2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FANCD2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FANCD2 mRNA20530235
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FANCD2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FANCD2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FANCD2 mRNA19140230
D014520UrethaneUrethane results in decreased expression of FANCD2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of FANCD2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FANCD2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12093742  12874027  15115758  17460694  18212739  19609304  
20603015  20603016  20603073  20805509  
GO:0070182DNA polymerase binding-IBA21873635  
GO:0070182DNA polymerase binding-IPI19995904  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IBA21873635  
GO:0007129synapsis-IEA-  
GO:0007276gamete generation-IEA-  
GO:0010332response to gamma radiation-IDA12874027  
GO:0034599cellular response to oxidative stress-IEA-  
GO:0036297interstrand cross-link repair-TAS-  
GO:0045589regulation of regulatory T cell differentiation-IEA-  
GO:0048854brain morphogenesis-IEA-  
GO:0050727regulation of inflammatory response-IEA-  
GO:0051090regulation of DNA-binding transcription factor activity-IEA-  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO:2000348regulation of CD40 signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000793condensed chromosome-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA26323318  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28729482BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. (2017 Oct)Tacconi EMEMBO Mol Med