Gene: ALDH3A1

218
ALDH3|ALDHIII
aldehyde dehydrogenase 3 family member A1
protein-coding
17p11.2
Ensembl:ENSG00000108602 MIM:100660 Vega:OTTHUMG00000059469 UniprotKB:P30838
NG_012251.1
PubMed
0   ANCO-SNPs
CD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.440e-1 (AD)  1.013e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKN1C0.502
CD550.502
S100A20.484
KLK130.466
CSTA0.465
ANXA10.463
LGALS20.456
DYRK40.448
SERPINB30.447
AATF0.446

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POU3F4-0.284
DIO2-0.256
KIF26B-0.247
CCDC85C-0.245
SALL3-0.244
NTN3-0.242
HKDC1-0.237
ZNF469-0.234
FAM151A-0.227
WNT7B-0.227

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0407561,2-naphthoquinone"1,2-naphthoquinone results in increased expression of ALDH3A1 mRNA"26558468
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ALDH3A1 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ALDH3A1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ALDH3A1 mRNA"20566336
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH3A1 mRNA"19114083
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased expression of ALDH3A1 mRNA"21724226|2404627
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased expression of ALDH3A1 mRNA"21724226|2404627
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ALDH3A1 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH3A1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDH3A1 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ALDH3A1 mRNA"20816883
C0517502-hexenalALDH3A1 protein affects the metabolism of 2-hexenal11306050
C0517502-hexenalALDH3A1 protein results in decreased susceptibility to 2-hexenal11306050
C0517502-hexenalALDH3A1 protein results in increased metabolism of 2-hexenal21256123
C0498262-methoxyacetaldehydeALDH3A1 protein results in increased oxidation of 2-methoxyacetaldehyde18940187
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ALDH3A1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ALDH3A1 mRNA]28655636
C0131662-nonenalALDH3A1 protein affects the metabolism of 2-nonenal11306050
C0131662-nonenalALDH3A1 protein results in decreased susceptibility to 2-nonenal11306050
C0573482-octenalALDH3A1 protein affects the metabolism of 2-octenal11306050
C0573482-octenalALDH3A1 protein results in decreased susceptibility to 2-octenal11306050
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALDH3A1 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALDH3A1 mRNA"23994337
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALDH3A1 mRNA"19692669|2095900
C0555064-(diethylamino)benzaldehydeALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde25512087
C0275764-hydroxy-2-nonenalALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal15905174
C0275764-hydroxy-2-nonenalALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal11306050
C0275764-hydroxy-2-nonenalALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal22339434
C0275764-hydroxy-2-nonenalALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal21256123
C0275764-hydroxy-2-nonenal[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal21967605
C0275764-hydroxy-2-nonenalALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal11018474
C0086424-nitrophenyl acetateALDH3A1 protein results in increased hydrolysis of 4-nitrophenyl acetate21349255
D000079AcetaldehydeALDH3A1 protein results in increased oxidation of Acetaldehyde18940187
D000079AcetaldehydeALDH3A1 protein results in increased metabolism of Acetaldehyde21256123
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH3A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ALDH3A1 mRNA17562736
D000171AcroleinALDH3A1 protein results in increased metabolism of Acrolein21256123
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ALDH3A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ALDH3A1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ALDH3A1 mRNA23630614
D000393Air PollutantsAir Pollutants results in increased expression of ALDH3A1 mRNA18079490
C006446aldophosphamide[ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamide10856427
C006446aldophosphamide[ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide10856427
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALDH3A1 mRNA16483693
D001151ArsenicArsenic results in decreased expression of ALDH3A1 protein19818359
C006632arsenic trioxideALDH3A1 protein inhibits the reaction [PML mutant form results in increased susceptibility to arsenic trioxide]26118777
C006632arsenic trioxideALDH3A1 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in decreased methylation of ALDH3A1 promoter23974009
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ALDH3A1 mRNA15894712
C015001arsenitearsenite results in increased expression of ALDH3A1 mRNA15894712
D001374Azacitidine[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D001374AzacitidineAzacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
C032175benzaldehyde[ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde10856427
C032175benzaldehyde[ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde10856427
C032175benzaldehydeALDH3A1 protein results in increased oxidation of benzaldehyde21349255|2322059
C032175benzaldehydeCimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]23220590
C032175benzaldehydeALDH3A1 protein results in increased metabolism of benzaldehyde21256123
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ALDH3A1 mRNA25218365|2860143
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ALDH3A1 mRNA17998271|2399433
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ALDH3A1 mRNA1416978
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3A1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH3A1 mRNA14645679|1654541
D001564Benzo(a)pyrenecobaltous chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D001564Benzo(a)pyreneDeferoxamine inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D001564Benzo(a)pyrenenickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D001564Benzo(a)pyreneOxygen deficiency inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ALDH3A1 mRNA15894712
D001564Benzo(a)pyrene[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D001564Benzo(a)pyreneAzacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ALDH3A1 mRNA22613061
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ALDH3A1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [sodium bichromate results in decreased expression of ALDH3A1 mRNA]22613061
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH3A1 mRNA14625279|1503420
D001564Benzo(a)pyreneButyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D001564Benzo(a)pyreneChromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]17682057
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14625279
C031403benzyl isothiocyanateALDH3A1 protein results in increased susceptibility to benzyl isothiocyanate28821405
C031403benzyl isothiocyanatebenzyl isothiocyanate results in increased expression of ALDH3A1 mRNA28821405
C031403benzyl isothiocyanatebenzyl isothiocyanate results in increased expression of ALDH3A1 protein28821405
C031403benzyl isothiocyanateNFE2L2 protein promotes the reaction [benzyl isothiocyanate results in increased expression of ALDH3A1 mRNA]28821405
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ALDH3A1 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]18691609
C006780bisphenol Abisphenol A affects the expression of ALDH3A1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of ALDH3A1 mRNA25181051
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of ALDH3A1 mRNA17998271
D002087Butyrates[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D002087ButyratesButyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D002211CapsaicinCapsaicin results in decreased expression of ALDH3A1 mRNA16278290
D002509CephaloridineCephaloridine results in increased expression of ALDH3A1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ALDH3A1 mRNA18178546
C100187chloropicrinchloropicrin results in increased expression of ALDH3A1 mRNA26352163|2847649
D002737ChloropreneChloroprene results in increased expression of ALDH3A1 mRNA23125180
D002857Chromium[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D002857ChromiumAzacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D002857ChromiumButyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]17682057
D002857ChromiumChromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]17682057
D002927CimetidineCimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]23220590
D002994ClofibrateClofibrate results in decreased expression of ALDH3A1 mRNA12604186
D002994ClofibratePPARG protein promotes the reaction [Clofibrate results in decreased expression of ALDH3A1 mRNA]12604186
C018021cobaltous chloridecobaltous chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALDH3A1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDH3A1 mRNA24386269
D009243NAD[ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamide10856427
D009243NAD[ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde10856427
D009243NADNAD results in increased activity of ALDH3A1 protein21256123
D009249NADP[ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamide10856427
D009249NADP[ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde10856427
D009249NADPNADP results in increased activity of ALDH3A1 protein21256123
D003513CycloheximideCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]1953764
D003520CyclophosphamideALDH3A1 protein affects the susceptibility to Cyclophosphamide18854779
D003520CyclophosphamideALDH3A1 protein affects the susceptibility to Cyclophosphamide25641190
D016572CyclosporineCyclosporine results in decreased expression of ALDH3A1 mRNA20106945
D003671DEETDEET results in increased expression of ALDH3A1 mRNA27091632
D003676DeferoxamineDeferoxamine inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D003676DeferoxamineDeferoxamine results in decreased expression of ALDH3A1 mRNA14645679
D003907DexamethasoneDexamethasone results in decreased expression of ALDH3A1 mRNA22733784
D016190CarboplatinALDH3A1 protein affects the susceptibility to Carboplatin18854779
C023614dibenzofurandibenzofuran analog results in increased expression of ALDH3A1 mRNA20566336
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ALDH3A1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ALDH3A1 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ALDH3A1 mRNA18042831|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3A1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDH3A1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ALDH3A1 mRNA19638242
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ALDH3A1 mRNA22129741
D004221DisulfiramALDH3A1 protein results in increased metabolism of Disulfiram18591790
D004050DitiocarbALDH3A1 protein results in increased chemical synthesis of Ditiocarb18591790
D004237DiuronDiuron metabolite results in decreased expression of ALDH3A1 mRNA24172598
D004237DiuronDiuron results in decreased expression of ALDH3A1 mRNA25152437
D004237DiuronDiuron results in increased expression of ALDH3A1 mRNA21551480
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNA26159488
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ALDH3A1 mRNA24534155
D000431Ethanol[Ethanol co-treated with Zinc Sulfate] results in increased activity of ALDH3A1 protein15920153
D000431EthanolEthanol results in increased activity of ALDH3A1 protein15920153
D005047EtoposideALDH3A1 protein affects the susceptibility to Etoposide15905174
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ALDH3A1 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of ALDH3A1 mRNA28329830
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]17317680
D005557FormaldehydeFormaldehyde results in decreased expression of ALDH3A1 mRNA27664576
C004312glycidolglycidol results in decreased expression of ALDH3A1 mRNA24915197
C057286indenoindoleindenoindole results in increased activity of ALDH3A1 protein7955076
C016517indole-3-carbinolindole-3-carbinol affects the expression of ALDH3A1 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ALDH3A1 mRNA22129741
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of ALDH3A1 mRNA"23994337
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ALDH3A1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ALDH3A1 mRNA28988120
D008315MalondialdehydeALDH3A1 protein results in increased metabolism of Malondialdehyde21256123
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ALDH3A1 mRNA28601433
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ALDH3A1 mRNA20713471
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ALDH3A1 mRNA1416978
D020366MethylmethacrylateMethylmethacrylate results in increased expression of ALDH3A1 mRNA16916219
D016685MitomycinALDH3A1 protein affects the susceptibility to Mitomycin15905174
D009151Mustard GasMustard Gas results in increased expression of ALDH3A1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ALDH3A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALDH3A1 mRNA"25554681
C053320n-butoxyacetaldehydeALDH3A1 protein results in increased oxidation of n-butoxyacetaldehyde18940187
C010463n-hexanalALDH3A1 protein affects the metabolism of n-hexanal11306050
C010463n-hexanalALDH3A1 protein results in decreased susceptibility to n-hexanal11306050
D009532NickelNickel results in increased expression of ALDH3A1 mRNA25583101
C022838nickel chloridenickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
C022838nickel chloridenickel chloride affects the expression of ALDH3A1 mRNA22110744
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ALDH3A1 mRNA17616710
D009853OmeprazoleOmeprazole results in increased expression of ALDH3A1 mRNA12040753
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of ALDH3A1 mRNA23212921
D010100OxygenOxygen deficiency inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14645679
D010100OxygenOxygen deficiency results in decreased expression of ALDH3A1 mRNA14645679
D000073878Palm OilPalm Oil results in increased expression of ALDH3A1 mRNA18042831
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of ALDH3A1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of ALDH3A1 mRNA19410595|2217879
C011272perfosfamideALDH3A1 protein results in decreased susceptibility to perfosfamide16614850
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ALDH3A1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ALDH3A1 mRNA23557933
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]14625279
D011374ProgesteroneProgesterone results in decreased expression of ALDH3A1 mRNA18037150
C005556propionaldehydeALDH3A1 protein results in increased metabolism of propionaldehyde19822198
C005556propionaldehydeALDH3A1 protein results in increased metabolism of propionaldehyde21256123
D011441PropylthiouracilPropylthiouracil results in increased expression of ALDH3A1 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of ALDH3A1 protein17337753
D011691PuromycinPuromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]1953764
D012172RetinaldehydeRetinaldehyde results in increased activity of ALDH3A1 protein17126819
C541923sandostatinLARsandostatinLAR results in increased expression of ALDH3A1 mRNA17210224
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ALDH3A1 mRNA23806026
D012834SilverSilver results in increased expression of ALDH3A1 mRNA27131904
D019821SimvastatinSimvastatin results in increased expression of ALDH3A1 mRNA17428261
C017947sodium arsenitesodium arsenite results in increased expression of and affects the splicing of ALDH3A1 mRNA25879800
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ALDH3A1 mRNA22613061
C016104sodium bichromateBenzo(a)pyrene promotes the reaction [sodium bichromate results in decreased expression of ALDH3A1 mRNA]22613061
C016104sodium bichromatesodium bichromate results in decreased expression of ALDH3A1 mRNA22613061
C016104sodium bichromatesodium bichromate results in increased expression of ALDH3A1 mRNA12325037
D053260SootSoot results in decreased expression of ALDH3A1 mRNA19165387|2655175
C561322sparstolonin Bsparstolonin B results in increased expression of ALDH3A1 mRNA23940584
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNA26159488
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH3A1 mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR mRNA] affects the expression of ALDH3A1 mRNA20619336
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA12377990|1534536
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]1416978
D013749TetrachlorodibenzodioxinARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]7828219
D013749TetrachlorodibenzodioxinCHUK protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]24519526
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH3A1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to ALDH3A1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of ALDH3A1 protein7828219|7955076
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA10677587|1416978
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH3A115993909
D013749TetrachlorodibenzodioxinCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]1953764
D013749TetrachlorodibenzodioxinPuromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]1953764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH3A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA1416978|16054898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH3A1 protein16497791|1654806
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased activity of ALDH3A1 protein1416978
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ALDH3A1 mRNA28943392
D013852ThiotepaALDH3A1 protein affects the susceptibility to Thiotepa18854779
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ALDH3A1 mRNA27404394|2745050
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of ALDH3A1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALDH3A1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ALDH3A1 protein26609137
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ALDH3A1 protein27818348
D014212TretinoinTretinoin results in decreased activity of ALDH3A1 protein16614850
D014212TretinoinTretinoin results in decreased expression of ALDH3A1 protein16614850
D014212TretinoinTretinoin results in decreased expression of and results in decreased activity of ALDH3A1 protein15470086
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ALDH3A1 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALDH3A1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ALDH3A1 mRNA28818685
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of ALDH3A1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ALDH3A1 mRNA28655636
D014752Vinyl ChlorideVinyl Chloride results in increased activity of ALDH3A1 protein15211785
D002762CholecalciferolCholecalciferol results in increased expression of ALDH3A1 mRNA17170073
D019287Zinc Sulfate[Ethanol co-treated with Zinc Sulfate] results in increased activity of ALDH3A1 protein15920153

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00040283-chloroallyl aldehyde dehydrogenase activity-IBA21873635  
GO:00040283-chloroallyl aldehyde dehydrogenase activity-IEA-  
GO:0004029aldehyde dehydrogenase (NAD) activity-IDA1737758  
GO:0004030aldehyde dehydrogenase [NAD(P)+] activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO:0008106alcohol dehydrogenase (NADP+) activity-IDA1737758  
GO:0018479benzaldehyde dehydrogenase (NAD+) activity-IDA4015840  
GO ID GO Term Qualifier Evidence PubMed
GO:0006081cellular aldehyde metabolic process-IDA1737758  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0055114oxidation-reduction process-IDA1737758  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00340Histidine metabolism
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology
17920722ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors. (2008 Mar)Patel MLung Cancer
25218365Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with beta-naphthoflavone. (2014 Nov 18)Brauze DToxicol Lett
27542180A Graphical Model of Smoking-Induced Global Instability in Lung Cancer. (2018 Jan-Feb)Wang YIEEE/ACM Trans Comput Biol Bioinform
19894643The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method. (2009 Sep-Oct)Bogucka MActa Pol Pharm
21229876Salivary aldehyde dehydrogenase activity--influence of drugs intake, preliminary research. (2010 Nov-Dec)Giebultowicz JActa Pol Pharm
21349255Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. (2011 May 30)Parajuli BChem Biol Interact
20931090Salivary aldehyde dehydrogenase - temporal and population variability, correlations with drinking and smoking habits and activity towards aldehydes contained in food. (2010)Giebultowicz JActa Biochim Pol
25036363Susceptibility to COPD: differential proteomic profiling after acute smoking. (2014)Franciosi LPLoS One