Gene info: ID 2180

Gene: ACSL1

GENE ID: 2180

Description: acyl-CoA synthetase long chain family member 1

Gene type: protein-coding

Location: 4q35.1

dbXrefs: Ensembl:ENSG00000151726 MIM:152425 Vega:OTTHUMG00000160547 UniprotKB:P33121

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : 2.017e-1 (AD) 1.327e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.108e-1 (AD) 9.634e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LIPA	0.854
TMEM165	0.839
DIP2B	0.826
TBC1D12	0.826
CD55	0.823
MYO1E	0.819
RFFL	0.816
PRRG1	0.814
SYNGR2	0.812
TMC6	0.807

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.39
OR4F29	-0.388
SLC29A4	-0.366
OR4F5	-0.347
POU3F1	-0.336
CHRNA2	-0.318
WTIP	-0.314
ARSF	-0.311
PRTN3	-0.309
SHISA8	-0.309

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00131	Adenosine monophosphate	Small Molecule	61-19-8	Approved\|Investigational\|Nutraceutical	Target
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ACSL1 mRNA	25596134
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ACSL1 mRNA	25596134
C514353	1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid	1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid results in increased metabolism of ACSL1 protein	22765480
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ACSL1 mRNA"	20453058
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACSL1 mRNA"	19114083
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ACSL1 mRNA"	17547211
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ACSL1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of ACSL1 mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ACSL1 mRNA"	21346803
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ACSL1 protein	26194647
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ACSL1 mRNA]"	19467301
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of ACSL1 mRNA	14610520
C575631	4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile	"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of ACSL1 mRNA"	21218783
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ACSL1 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ACSL1 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of ACSL1 mRNA	20146248
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of ACSL1 mRNA	22230336\|2570463
D000082	Acetaminophen	Acetaminophen affects the expression of ACSL1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL1 mRNA	17585979
D000082	Acetaminophen	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of ACSL1 protein	25499718
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of ACSL1 mRNA	17522070
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ACSL1 mRNA	22100608\|2715375
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of ACSL1 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ACSL1 protein	26597043
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ACSL1 mRNA	16483693
D000965	Antimony	Antimony results in decreased expression of ACSL1 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of ACSL1 mRNA	17547211
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ACSL1 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ACSL1 mRNA	23912714
C015001	arsenite	arsenite results in increased expression of ACSL1 mRNA	23974009
C547126	AZM551248	AZM551248 results in decreased expression of ACSL1 mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of ACSL1 mRNA	23656298
D001554	Benzene	Benzene affects the expression of ACSL1 mRNA	21147609
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of ACSL1 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of ACSL1 mRNA	20146248
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ACSL1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ACSL1 mRNA	19770486
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of ACSL1 mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of ACSL1 mRNA	17404688
C095105	bexarotene	bexarotene results in increased expression of ACSL1 mRNA	23292798
D001629	Bezafibrate	Bezafibrate results in increased expression of ACSL1 mRNA	19682441\|2164070
D001629	Bezafibrate	Bezafibrate results in increased expression of ACSL1 mRNA	17118139\|1912461
D001629	Bezafibrate	Butyrates promotes the reaction [Bezafibrate results in increased expression of ACSL1 mRNA]	22338096
D001629	Bezafibrate	PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA]	19124612
C053541	bicalutamide	bicalutamide results in increased expression of ACSL1 mRNA	15790403
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACSL1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of ACSL1 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of ACSL1 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACSL1 mRNA	28628672
C032036	bromobenzene	bromobenzene results in decreased expression of ACSL1 mRNA	12628495
D002087	Butyrates	Butyrates promotes the reaction [Bezafibrate results in increased expression of ACSL1 mRNA]	22338096
D002087	Butyrates	Butyrates results in increased expression of ACSL1 mRNA	22338096
D002104	Cadmium	Cadmium results in increased oxidation of ACSL1 protein	24496640
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ACSL1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of ACSL1 promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of ACSL1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ACSL1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of ACSL1 mRNA	15963342
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ACSL1 mRNA	17522070
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ACSL1 mRNA	16239168
D002273	Carcinogens	Carcinogens results in decreased expression of ACSL1 mRNA	16316942
D002713	Chlorine	Chlorine results in decreased expression of ACSL1 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of ACSL1 mRNA	18636392
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of ACSL1 mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ACSL1 mRNA	23650126
D002725	Chloroform	Chloroform results in decreased expression of ACSL1 mRNA	17522070
D002794	Choline	Choline deficiency results in increased expression of ACSL1 mRNA	25178843
D002857	Chromium	Chromium results in decreased expression of ACSL1 mRNA	17547211
C059262	cidofovir	cidofovir results in decreased expression of ACSL1 mRNA	25596134
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of ACSL1 mRNA	16197558
C019304	ciprofibrate	ciprofibrate results in increased expression of ACSL1 mRNA	27225895
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of ACSL1 mRNA	25596134
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of ACSL1 mRNA	23811191
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of ACSL1 protein	20118634
D002994	Clofibrate	Clofibrate results in increased expression of ACSL1 mRNA	12851107
D002994	Clofibrate	Clofibrate results in increased expression of ACSL1 protein	16470657
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ACSL1 mRNA	11078357
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of ACSL1 mRNA	20971185
D003300	Copper	Copper deficiency results in decreased expression of ACSL1 mRNA	19821111
D003300	Copper	Copper results in decreased expression of ACSL1 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ACSL1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine affects the expression of ACSL1 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in decreased expression of ACSL1 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased methylation of ACSL1 promoter	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of ACSL1 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in decreased expression of ACSL1 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in decreased expression of ACSL1 mRNA	25596134
C093628	cyproconazole	cyproconazole results in decreased expression of ACSL1 mRNA	22334560
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased expression of ACSL1 mRNA	16940010
D003907	Dexamethasone	Dexamethasone results in increased expression of ACSL1 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACSL1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACSL1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSL1 mRNA	28628672
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACSL1 mRNA	23428407
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA	16054899
D003907	Dexamethasone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of ACSL1 mRNA	17522070
D064730	Dexrazoxane	Dexrazoxane results in decreased expression of ACSL1 mRNA	26873546
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of ACSL1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of ACSL1 mRNA	25596134
D002945	Cisplatin	Cisplatin results in increased expression of ACSL1 mRNA	27594783
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ACSL1 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of ACSL1 mRNA	16357043\|1946730
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ACSL1 mRNA	22672789
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ACSL1 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ACSL1 mRNA	19638242
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ACSL1 mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of ACSL1 mRNA	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of ACSL1 mRNA	25380136
D011397	Promegestone	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of ACSL1 mRNA]	15103026
D011397	Promegestone	Promegestone results in increased expression of ACSL1 mRNA	15103026
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]	24146112
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]	24146112
C550453	dioxinodehydroeckol	dioxinodehydroeckol results in decreased expression of ACSL1 mRNA	20385110
D004237	Diuron	Diuron results in decreased expression of ACSL1 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in decreased expression of ACSL1 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of ACSL1 mRNA	19915844
C071192	entacapone	entacapone binds to ACSL1 protein	19783845
C118739	entinostat	entinostat results in increased expression of ACSL1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of ACSL1 mRNA	16988119
C109476	epoxiconazole	epoxiconazole results in decreased expression of ACSL1 mRNA	22334560
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of ACSL1 mRNA	17522070
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]	24146112
D000431	Ethanol	Ethanol results in decreased expression of ACSL1 protein	24146112
D000431	Ethanol	[Zinc deficiency co-treated with Ethanol] results in increased expression of ACSL1 mRNA	24155903
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]	24146112
D000431	Ethanol	Ethanol results in decreased expression of ACSL1 mRNA	26115886
D000431	Ethanol	Ethanol results in decreased expression of ACSL1 protein	24146112
D000431	Ethanol	Ethanol results in increased expression of ACSL1 mRNA	15353170
D000431	Ethanol	Ethanol results in increased expression of ACSL1 protein	23200777
D000431	Ethanol	Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]	26115886
D000431	Ethanol	Silymarin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]	26115886
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ACSL1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ACSL1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ACSL1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ACSL1 mRNA	17108234
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of ACSL1 mRNA	23649840
D011345	Fenofibrate	Fenofibrate results in increased expression of ACSL1 mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in increased expression of ACSL1 mRNA	17118139
D011345	Fenofibrate	Fenofibrate affects the expression of ACSL1 mRNA	20801182
D011345	Fenofibrate	Fenofibrate results in decreased expression of ACSL1 protein	20118634
D011345	Fenofibrate	Fenofibrate results in increased expression of ACSL1 mRNA	10600944\|2559613
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of ACSL1 mRNA	16197558
D005279	Fenoprofen	ACSL1 protein results in increased metabolism of Fenoprofen	10725307
D005411	Flame Retardants	Flame Retardants results in decreased expression of ACSL1 mRNA	18534652
D005411	Flame Retardants	Flame Retardants results in increased expression of ACSL1 mRNA	18534652
D005485	Flutamide	Flutamide results in decreased expression of ACSL1 mRNA	17702527
D005485	Flutamide	Flutamide results in decreased expression of ACSL1 mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in decreased expression of ACSL1 mRNA	16221962
C039281	furan	furan binds to ACSL1 protein	22240984
C039281	furan	furan results in decreased expression of ACSL1 mRNA	26194646
C039281	furan	furan results in increased methylation of ACSL1 gene	22079235
C546771	gardiquimod	gardiquimod results in increased expression of ACSL1 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ACSL1 mRNA]	28003376
D005839	Gentamicins	Gentamicins results in decreased expression of ACSL1 mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of ACSL1 mRNA	24136188
C046905	glucosamine 6-O-sulfate	glucosamine 6-O-sulfate results in decreased expression of ACSL1 mRNA	19520133
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of ACSL1 mRNA	18534652
C089796	hexabromocyclododecane	hexabromocyclododecane results in increased expression of ACSL1 mRNA	18534652
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ACSL1 mRNA	20044591
D007052	Ibuprofen	Ibuprofen results in increased expression of ACSL1 mRNA	25596134
D007052	Ibuprofen	ACSL1 protein results in increased metabolism of Ibuprofen	10725307
D007052	Ibuprofen	Ibuprofen results in increased expression of ACSL1 mRNA	25596134
D007069	Ifosfamide	Ifosfamide results in decreased expression of ACSL1 mRNA	25596134
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACSL1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACSL1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSL1 mRNA	28628672
D007501	Iron	Iron deficiency results in decreased expression of ACSL1 mRNA	19821111
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACSL1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACSL1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSL1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACSL1 mRNA	23428407
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of ACSL1 mRNA	15618438
C410337	K 7174	K 7174 results in increased expression of ACSL1 mRNA	24086573
D007657	Ketone Bodies	Ketone Bodies results in increased expression of ACSL1 mRNA	15469884
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of ACSL1 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACSL1 mRNA"	20371263
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of ACSL1 mRNA	20359477
D008095	Lithocholic Acid	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]	20359477
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of ACSL1 mRNA	18497975
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
D008628	Mercury	Mercury results in decreased expression of ACSL1 mRNA	17547211
D008687	Metformin	Metformin results in decreased expression of ACSL1 mRNA	25596134
C013598	methoxyacetic acid	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of ACSL1 mRNA]	15103026
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate affects the expression of ACSL1 mRNA	28349193
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ACSL1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ACSL1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ACSL1 mRNA"	20188158
D016685	Mitomycin	ACSL1 protein affects the susceptibility to Mitomycin	16217747
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of ACSL1 protein	27384973
C500085	muraglitazar	muraglitazar results in increased expression of ACSL1 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ACSL1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ACSL1 mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of ACSL1 mRNA	17522070\|2538013
C051752	nefazodone	nefazodone results in decreased expression of ACSL1 mRNA	24136188
C022838	nickel chloride	nickel chloride results in decreased expression of ACSL1 mRNA	17547211
C022838	nickel chloride	nickel chloride affects the expression of ACSL1 mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in decreased expression of ACSL1 mRNA	19167457
D009534	Niclosamide	Niclosamide results in decreased expression of ACSL1 mRNA	22576131
D009538	Nicotine	Nicotine results in increased splicing of ACSL1 mRNA alternative form	23825647
C012655	nimesulide	nimesulide results in decreased expression of ACSL1 mRNA	24136188
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in decreased expression of ACSL1 mRNA	22561872
C025256	nonylphenol	nonylphenol results in increased expression of ACSL1 mRNA	22982499
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of ACSL1 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in decreased expression of ACSL1 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in increased expression of ACSL1 mRNA	16251485
C046627	osthol	osthol results in increased expression of ACSL1 mRNA	19682441
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSL1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of ACSL1 mRNA	25596134
D010100	Oxygen	Oxygen deficiency results in increased expression of ACSL1 mRNA	22629407
D010100	Oxygen	Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of ACSL1 mRNA]	22629407
D010126	Ozone	Ozone results in decreased expression of ACSL1 mRNA	12763052
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of ACSL1 mRNA	18636392
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of ACSL1 mRNA	26272509
C016030	pantogab	pantogab results in increased expression of ACSL1 mRNA	17379144
D010269	Paraquat	Paraquat affects the expression of ACSL1 mRNA	15206577
D010269	Paraquat	Paraquat results in decreased expression of ACSL1 mRNA	18198484
C539348	perfluorobutanesulfonic acid	perfluorobutanesulfonic acid results in increased expression of ACSL1 mRNA	21705711
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of ACSL1 mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of ACSL1 mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of ACSL1 mRNA	21705711
C479228	perfluorohexanoic acid	perfluorohexanoic acid results in increased expression of ACSL1 mRNA	23567314
C101815	perfluoro-n-heptanoic acid	perfluoro-n-heptanoic acid results in increased expression of ACSL1 mRNA	23567314
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of ACSL1 mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ACSL1 mRNA	17560707
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of ACSL1 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ACSL1 mRNA	20936131\|2170571
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ACSL1 mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACSL1 mRNA	23567314
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACSL1 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of ACSL1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACSL1 mRNA	18467677\|2093613
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL1 mRNA]	18467677\|2093613
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ACSL1 mRNA	28511854
D010634	Phenobarbital	Phenobarbital results in decreased expression of ACSL1 mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ACSL1 mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in decreased expression of ACSL1 mRNA	22538082
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSL1 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSL1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ACSL1 mRNA	15302862\|1537516
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of ACSL1 mRNA]	16221962
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACSL1 mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of ACSL1 mRNA	16940010\|1916217
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of ACSL1 mRNA	17547211
D017035	Pravastatin	Pravastatin results in decreased expression of ACSL1 mRNA	27225895
D011239	Prednisolone	Prednisolone results in increased expression of ACSL1 mRNA	17379860
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ACSL1 mRNA	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ACSL1 mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of ACSL1 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of ACSL1 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of ACSL1 mRNA	17404688\|2086464
D011374	Progesterone	Progesterone results in increased expression of ACSL1 mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of ACSL1 mRNA	22334560
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ACSL1 mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ACSL1 mRNA]	28003376
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of ACSL1 mRNA	26100227
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA	19059307
C488333	Ro 65-7199	Ro 65-7199 results in decreased expression of ACSL1 mRNA	14610520
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA	16054899
C089730	rosiglitazone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone affects the expression of ACSL1 mRNA	22013433
C089730	rosiglitazone	rosiglitazone results in increased expression of ACSL1 mRNA	15520860\|1724559
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of ACSL1 mRNA	21515302\|2559613
D012603	Scopoletin	Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]	26115886
C009238	senkirkine	senkirkine results in decreased expression of ACSL1 mRNA	26100227
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ACSL1 mRNA	23221170
D012838	Silymarin	Silymarin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]	26115886
C017947	sodium arsenite	sodium arsenite results in increased expression of ACSL1 mRNA	21457566
C016104	sodium bichromate	sodium bichromate affects the expression of ACSL1 mRNA	22110744
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of ACSL1 mRNA	27862939
C075117	squalestatin 1	squalestatin 1 affects the expression of ACSL1 mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of ACSL1 mRNA	27225895
C016766	sulforafan	sulforafan results in increased expression of ACSL1 mRNA	26833863
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACSL1 mRNA"	20371263
D013629	Tamoxifen	Tamoxifen affects the expression of ACSL1 mRNA	14699072
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA	19059307
D013629	Tamoxifen	Tamoxifen affects the expression of ACSL1 mRNA	17555576
C021751	tanshinone	tanshinone results in increased expression of ACSL1 mRNA	15849732
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of ACSL1 mRNA	15885361
C501413	tesaglitazar	tesaglitazar results in increased expression of ACSL1 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACSL1 gene]	28681081
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ACSL1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ACSL1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNA	19770486\|2253962
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ACSL1 mRNA	17035482
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNA	18796159\|2121527
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ACSL1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of ACSL1 mRNA	24489787
D013752	Tetracycline	Tetracycline results in increased expression of ACSL1 mRNA	16917069
D013752	Tetracycline	Tetracycline results in decreased expression of ACSL1 mRNA	17522070
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ACSL1 mRNA	28943392
C009495	titanium dioxide	titanium dioxide affects the expression of ACSL1 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in decreased expression of ACSL1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ACSL1 protein	22609517
C066340	tolcapone	tolcapone binds to ACSL1 protein	19783845
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSL1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of ACSL1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of ACSL1 mRNA	21934132
C011559	tributyltin	tributyltin results in increased expression of ACSL1 mRNA	23428407
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ACSL1 mRNA	19254012\|2897337
C012589	trichostatin A	trichostatin A results in increased expression of ACSL1 mRNA	24935251
C057693	troglitazone	troglitazone results in increased expression of ACSL1 mRNA	12732648
C057693	troglitazone	troglitazone results in decreased expression of ACSL1 mRNA	9452481
C057693	troglitazone	troglitazone results in increased expression of ACSL1 mRNA	21515302\|2559613
C057693	troglitazone	troglitazone results in increased expression of ACSL1 protein	21315101
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in decreased expression of ACSL1 mRNA]	12732648
D014425	Turpentine	Turpentine results in decreased expression of ACSL1 mRNA	16044259
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSL1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ACSL1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ACSL1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of ACSL1 mRNA	24489787
D014640	Vancomycin	Vancomycin results in increased expression of ACSL1 mRNA	18930951
C025643	vinclozolin	vinclozolin affects the expression of ACSL1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of ACSL1 mRNA	22570695
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of ACSL1 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ACSL1 mRNA	20044591
D015032	Zinc	[Zinc deficiency co-treated with Ethanol] results in increased expression of ACSL1 mRNA	24155903
D015032	Zinc	Zinc deficiency results in decreased expression of ACSL1 mRNA	24155903
D015032	Zinc	Zinc deficiency results in increased expression of ACSL1 mRNA	12672911\|1567121
D015034	Zinc Oxide	Zinc Oxide affects the expression of ACSL1 protein	28648595
C088658	zoledronic acid	zoledronic acid results in decreased expression of ACSL1 mRNA	25596134
C088658	zoledronic acid	zoledronic acid results in decreased expression of ACSL1 protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004467	long-chain fatty acid-CoA ligase activity	-	IDA	21242590 22022213
GO:0004467	long-chain fatty acid-CoA ligase activity	-	TAS	-
GO:0005524	ATP binding	-	IEA	-
GO:0102391	decanoate-CoA ligase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001676	long-chain fatty acid metabolic process	-	IDA	22022213
GO:0007584	response to nutrient	-	IEA	-
GO:0008610	lipid biosynthetic process	-	IDA	21242590
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0019432	triglyceride biosynthetic process	-	IEA	-
GO:0033211	adiponectin-activated signaling pathway	-	IEA	-
GO:0034201	response to oleic acid	-	IEA	-
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	-	TAS	-
GO:0036109	alpha-linolenic acid metabolic process	-	TAS	-
GO:0042178	xenobiotic catabolic process	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0043651	linoleic acid metabolic process	-	TAS	-
GO:0044539	long-chain fatty acid import	-	IDA	22022213
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	22022213
GO:0005741	mitochondrial outer membrane	-	TAS	-
GO:0005778	peroxisomal membrane	-	IEA	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00071	Fatty acid degradation
hsa01100	Metabolic pathways
hsa03320	PPAR signaling pathway
hsa04146	Peroxisome
hsa04920	Adipocytokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	TAS
R-HSA-2046105	Linoleic acid (LA) metabolism	TAS
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-75105	Fatty acyl-CoA biosynthesis	TAS
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28550509	Possible involvement of ACSS2 gene in alcoholism. (2017 Sep)	Ribeiro AF	J Neural Transm (Vienna)