Gene: PTK2B

2185
CADTK|CAKB|FADK2|FAK2|PKB|PTK|PYK2|RAFTK
protein tyrosine kinase 2 beta
protein-coding
8p21.2
Ensembl:ENSG00000120899 MIM:601212 Vega:OTTHUMG00000102082 UniprotKB:Q14289
NG_029510.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.584e-2 (AD)  6.205e-3 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10345404chr8:27187123PTK2B5.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAMKK10.948
PHYHIP0.947
PRRT20.947
CIT0.944
KIAA1211L0.943
PDE1B0.943
CAMK1G0.942
UNC5A0.941
NCKIPSD0.939
NGEF0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.526
OR4F5-0.524
TFPI2-0.503
ZNF114-0.5
SGMS2-0.491
OR4F29-0.479
HEY2-0.472
HAS2-0.471
C9orf135-0.469
YES1-0.463

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01097LeflunomideSmall Molecule75706-12-6Approved|InvestigationalTarget
DB01645GenisteinSmall Molecule446-72-0InvestigationalTarget
DB083414-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamideSmall MoleculeExperimentalTarget
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]"16948116
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PTK2B protein]"21705713
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PTK2B mRNA"21346803
C4362842-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Acrylamide results in increased phosphorylation of PTK2B protein]11478917
C4362842-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]11478917
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PTK2B mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTK2B mRNA"18648102
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]"16877402
C0030017-ketocholesterol7-ketocholesterol results in increased phosphorylation of and results in increased activity of PTK2B protein15955068
D000082AcetaminophenAcetaminophen results in increased expression of PTK2B mRNA22230336
C056165acetovanilloneacetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]23774252
D000111AcetylcysteineAcetylcysteine inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]23774252
D020106Acrylamide2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Acrylamide results in increased phosphorylation of PTK2B protein]11478917
D020106AcrylamideAcrylamide results in increased phosphorylation of PTK2B protein11478917
D020106AcrylamideAcrylamide results in increased expression of PTK2B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTK2B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTK2B mRNA19770486
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein11978788
C031143AICA ribonucleotidePTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]11978788
C031143AICA ribonucleotidePTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C000188alachlor[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTK2B mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of PTK2B protein modified form16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PTK2B protein16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PTK2B protein modified form16483693
D001151ArsenicArsenic affects the methylation of PTK2B gene25304211
C006632arsenic trioxidearsenic trioxide affects the expression of PTK2B mRNA28786057
D001194AsbestosAsbestos results in decreased expression of PTK2B mRNA22076105
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PTK2B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTK2B mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of PTK2B mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PTK2B mRNA25181051
D0200011-Butanol1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein]15705590
D0200011-Butanol1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]18004999
C018475butyraldehydebutyraldehyde results in decreased expression of PTK2B mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of PTK2B mRNA16122865
D002118CalciumCalcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]16236484
D002118CalciumCalcium affects the phosphorylation of and affects the activity of PTK2B protein16877402
D002215Captan[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D002217Carbachol"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]"16877402
D002217CarbacholCarbachol results in increased phosphorylation of and results in increased activity of PTK2B protein16877402
D002217CarbacholEgtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]16877402
D002217CarbacholPTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]16877402
D002217CarbacholPTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]16877402
D002217CarbacholSRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]16877402
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of PTK2B mRNA27793765
D060729Coal AshCoal Ash results in decreased expression of PTK2B mRNA19000753
D003042CocaineCocaine results in increased expression of PTK2B mRNA11299316
D003042CocaineCocaine results in increased expression of PTK2B protein11299316
D003042CocaineCocaine results in increased expression of PTK2B protein12117546
D003078Colchicine2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]11478917
D003078ColchicineColchicine results in increased phosphorylation of PTK2B protein11478917
D003471CuprizoneCuprizone results in decreased expression of PTK2B mRNA26577399
D003907DexamethasoneDexamethasone results in increased expression of PTK2B mRNA12782123|2504701
D003907DexamethasoneNR3C1 protein affects the reaction [Dexamethasone results in increased phosphorylation of PTK2B protein]18515658
D003976Diazinon[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTK2B mRNA17361019|2126653
C000944dicrotophosdicrotophos results in increased expression of PTK2B mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of PTK2B mRNA25016146
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]23774252
D004317DoxorubicinPTK2B protein inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]16168102
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]16877402
D004726Endosulfan[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D000431EthanolEthanol results in increased phosphorylation of PTK2B protein18182400
D000431Ethanolsodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein]18182400
D005419FlavonoidsFlavonoids results in decreased expression of PTK2B mRNA18035473
C053629fluoroaluminumfluoroaluminum results in increased phosphorylation of PTK2B protein11792571
D005473FluoxetineFluoxetine results in decreased expression of PTK2B mRNA17033635
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA20938992
C039281furanfuran results in decreased expression of PTK2B mRNA24183702
C039281furanfuran results in increased expression of PTK2B mRNA25539665
C010176halofuginonehalofuginone results in increased expression of PTK2B mRNA17180598
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNA17183730
D006861Hydrogen Peroxide1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein]15705590
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [CRK protein binds to PTK2B protein]16187300
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]15705590
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of PTK2B protein15705590
D006861Hydrogen PeroxidePLD2 protein affects the reaction [Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]]15705590
D006861Hydrogen PeroxidePTK2B protein affects the reaction [Hydrogen Peroxide results in increased activity of and results in increased phosphorylation of AKT1 protein]15705590
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTK2B mRNA25613284
D015759IonomycinIonomycin results in increased phosphorylation of and results in increased activity of PTK2B protein16877402
D007854LeadLead results in decreased expression of PTK2B mRNA19921347
D008094Lithium[Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein16600505
C032881lysophosphatidic acidlysophosphatidic acid results in increased phosphorylation of PTK2B protein11792571
C013099mancozeb[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D008344Maneb[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form19883720
D008345ManganeseManganese results in decreased expression of PTK2B mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of PTK2B mRNA17175027
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]16948116
D015767MefloquinePTK2B protein results in increased susceptibility to Mefloquine21241737
D008713MethimazoleMethimazole results in increased expression of PTK2B mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTK2B mRNA20938992
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PTK2B mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTK2B mRNA"22076105
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTK2B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTK2B mRNA"25620056
C031721naphthalenenaphthalene results in increased expression of PTK2B mRNA18978301
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PTK2B mRNA19812364
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased activity of PTK2B protein]19556728
C511689(N)-methanocarba-2MeSADPCalcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]16236484
C511689(N)-methanocarba-2MeSADPIGF1 protein affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]16236484
C511689(N)-methanocarba-2MeSADP(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein16236484
C511689(N)-methanocarba-2MeSADPPLD2 protein affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]16236484
C507134ON 01910ON 01910 results in increased phosphorylation of PTK2B protein25472472
C016030pantogabpantogab results in decreased expression of PTK2B mRNA17379144
D010261ParaoxonParaoxon results in increased expression of PTK2B mRNA24413757
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTK2B mRNA"25510870
D010862Pilocarpine[Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein16600505
C006253pirinixic acidpirinixic acid results in decreased expression of PTK2B mRNA23811191
C545373ponatinibponatinib results in decreased activity of PTK2B protein19878872
D011189Potassium Chloride1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]18004999
D011189Potassium ChloridePLD2 protein promotes the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]18004999
D011189Potassium ChloridePotassium Chloride results in increased phosphorylation of PTK2B protein18004999
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTK2B mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of PTK2B mRNA23012394|2301818
C045950propiconazolepropiconazole results in decreased expression of PTK2B mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of PTK2B mRNA22504374
D015237DinoprostDinoprost results in increased expression of PTK2B mRNA11517196
C012526quercitrinquercitrin affects the expression of PTK2B mRNA25193878
C059514resveratrolresveratrol results in increased expression of PTK2B mRNA23419489
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PTK2B mRNA23623845
D012906SmokeSmoke results in decreased expression of PTK2B mRNA21095227
C017947sodium arsenitesodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein]18182400
C017947sodium arsenitesodium arsenite results in increased expression of PTK2B protein19072884
D012999SomanSoman results in decreased expression of PTK2B mRNA19281266
C061133tamibarotenetamibarotene results in increased expression of PTK2B mRNA15498508
D013629TamoxifenTamoxifen results in decreased expression of PTK2B mRNA15590111
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of PTK2B mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTK2B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTK2B mRNA25613284
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of PTK2B protein16877402
C009495titanium dioxidetitanium dioxide results in increased expression of PTK2B mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PTK2B mRNA28065790
D014212Tretinoin[Tretinoin co-treated with CXCL12 protein] results in increased expression of PTK2B protein17656649
D014212TretinoinTretinoin results in increased expression of PTK2B mRNA15498508|1589460
C447082tricarbonyldichlororuthenium (II) dimerPTK2B protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]26385185
C447082tricarbonyldichlororuthenium (II) dimerPTK2B protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased phosphorylation of PTK2B protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer promotes the reaction [PDGFRA protein binds to PTK2B protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PTK2B protein26385185
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PTK2B mRNA25549359
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]16948116
D014520UrethaneUrethane results in decreased expression of PTK2B mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNA17183730
D014639VanadiumVanadium results in decreased expression of PTK2B mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTK2B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PTK2B mRNA23034163
D014750VincristineVincristine results in increased phosphorylation of PTK2B protein11478917
D015032ZincZinc deficiency results in increased expression of PTK2B mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004683calmodulin-dependent protein kinase activity-ISS-  
GO:0004713protein tyrosine kinase activity-IDA12771146  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA7544443  10518561  
GO:0004972NMDA glutamate receptor activitycontributes_toISS-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI8849729  9020138  10521452  11149930  15661758  18086875  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IMP10022914  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:00434233-phosphoinositide-dependent protein kinase binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0001525angiogenesis-IBA21873635  
GO:0001556oocyte maturation-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001954positive regulation of cell-matrix adhesion-IMP18765415  
GO:0002040sprouting angiogenesis-ISS-  
GO:0002250adaptive immune response-IEA-  
GO:0002315marginal zone B cell differentiation-ISS-  
GO:0006468protein phosphorylation-TAS7529876  
GO:0006915apoptotic process-TAS10880513  
GO:0006968cellular defense response-ISS-  
GO:0006970response to osmotic stress-IEA-  
GO:0007165signal transduction-TAS7499242  10867021  
GO:0007166cell surface receptor signaling pathway-IMP8849729  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007172signal complex assembly-IEA-  
GO:0007173epidermal growth factor receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007229integrin-mediated signaling pathway-IMP15050747  
GO:0008284positive regulation of cell proliferation-IMP18765415  
GO:0008285negative regulation of cell proliferation-IMP15050747  
GO:0008360regulation of cell shape-IMP19086031  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009725response to hormone-IEA-  
GO:0009749response to glucose-IEA-  
GO:0010226response to lithium ion-IEA-  
GO:0010595positive regulation of endothelial cell migration-IDA21245381  
GO:0010656negative regulation of muscle cell apoptotic process-IEA-  
GO:0010752regulation of cGMP-mediated signaling-IEA-  
GO:0010758regulation of macrophage chemotaxis-ISS-  
GO:0010976positive regulation of neuron projection development-IMP17910947  
GO:0014009glial cell proliferation-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IDA7544443  
GO:0030154cell differentiation-IBA21873635  
GO:0030155regulation of cell adhesion-IBA21873635  
GO:0030155regulation of cell adhesion-IMP19086031  
GO:0030307positive regulation of cell growth-IEA-  
GO:0030335positive regulation of cell migration-IMP18765415  
GO:0030502negative regulation of bone mineralization-ISS-  
GO:0030838positive regulation of actin filament polymerization-IMP18765415  
GO:0031175neuron projection development-IEA-  
GO:0032960regulation of inositol trisphosphate biosynthetic process-ISS-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP8670418  
GO:0035235ionotropic glutamate receptor signaling pathway-ISS-  
GO:0035902response to immobilization stress-IEA-  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IDA9545257  10518561  
GO:0038083peptidyl-tyrosine autophosphorylation-ISS-  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042220response to cocaine-IEA-  
GO:0042542response to hydrogen peroxide-IEA-  
GO:0042976activation of Janus kinase activity-IMP8670418  
GO:0043066negative regulation of apoptotic process-IMP19880522  
GO:0043149stress fiber assembly-IEA-  
GO:0043267negative regulation of potassium ion transport-IDA7544443  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043534blood vessel endothelial cell migration-IEA-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-ISS-  
GO:0045087innate immune response-IBA21873635  
GO:0045429positive regulation of nitric oxide biosynthetic process-IEA-  
GO:0045453bone resorption-ISS-  
GO:0045471response to ethanol-IEA-  
GO:0045638negative regulation of myeloid cell differentiation-IMP15050747  
GO:0045727positive regulation of translation-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045860positive regulation of protein kinase activity-IMP7544443  
GO:0046330positive regulation of JNK cascade-IMP8670418  
GO:0046777protein autophosphorylation-TAS8849729  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP21245381  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048041focal adhesion assembly-IEA-  
GO:0048167regulation of synaptic plasticity-TAS25707991  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA10022914  10518561  21245381  
GO:0050848regulation of calcium-mediated signaling-IEA-  
GO:0051000positive regulation of nitric-oxide synthase activity-IEA-  
GO:0051279regulation of release of sequestered calcium ion into cytosol-ISS-  
GO:0051591response to cAMP-IEA-  
GO:0051592response to calcium ion-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-ISS-  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0060292long term synaptic depression-IEA-  
GO:0065003protein-containing complex assembly-TAS10867021  
GO:0070098chemokine-mediated signaling pathway-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP7544443  
GO:0071300cellular response to retinoic acid-IMP17910947  
GO:0071498cellular response to fluid shear stress-IEA-  
GO:0090630activation of GTPase activity-IEA-  
GO:2000058regulation of ubiquitin-dependent protein catabolic process-IDA19880522  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-IEA-  
GO:2000114regulation of establishment of cell polarity-ISS-  
GO:2000249regulation of actin cytoskeleton reorganization-ISS-  
GO:2000310regulation of NMDA receptor activity-ISS-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO:2000538positive regulation of B cell chemotaxis-ISS-  
GO:2000573positive regulation of DNA biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19880522  
GO:0005737cytoplasm-TAS7499242  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-IBA21873635  
GO:0005925focal adhesion-IDA18765415  
GO:0005938cell cortex-IEA-  
GO:0014069postsynaptic density-ISS-  
GO:0014069postsynaptic density-TAS25707991  
GO:0017146NMDA selective glutamate receptor complex-ISS-  
GO:0030027lamellipodium-IDA18765415  
GO:0030425dendrite-ISS-  
GO:0030426growth cone-ISS-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0043025neuronal cell body-ISS-  
GO:0043197dendritic spine-IBA21873635  
GO:0043197dendritic spine-IEA-  
GO:0044297cell body-ISS-  
GO:0045121membrane raft-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA18765415  
GO:0097440apical dendrite-ISS-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-391160Signal regulatory protein family interactionsTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020558Interleukin-2 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
18075463Protein tyrosine kinase 2beta as a candidate gene for hypertension. (2007 Nov)Kamide KPharmacogenet Genomics