Gene: BPTF

2186
FAC1|FALZ|NEDDFL|NURF301
bromodomain PHD finger transcription factor
protein-coding
17q24.2
Ensembl:ENSG00000171634 MIM:601819 Vega:OTTHUMG00000132254 UniprotKB:Q12830
NG_052828.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.939e-5 (AD)  8.932e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11870068chr17:67948399 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8071463chr17:67942539 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA20260.927
WDFY30.915
UBXN70.914
ZKSCAN10.907
SETD20.902
CDC42BPA0.898
GIGYF20.89
ARHGAP210.889
FAM208A0.889
ZNF3970.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.57
OR4F5-0.55
OR4F16-0.287
PLA2G5-0.26
VAX2-0.246
PRRX2-0.239
NANOGNB-0.228
HMX1-0.214
GAST-0.21
MUC12-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BPTF mRNA"27291303
C0127962-butenal2-butenal results in decreased expression of BPTF mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of BPTF mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of BPTF mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BPTF mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BPTF mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BPTF mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of BPTF mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of BPTF mRNA26079696
D002104CadmiumCadmium results in decreased expression of BPTF mRNA24067728
D002737ChloropreneChloroprene results in increased expression of BPTF mRNA23125180
D003024ClozapineClozapine results in decreased expression of BPTF mRNA14647396
D019327Copper SulfateCopper Sulfate results in decreased expression of BPTF mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of BPTF mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of BPTF mRNA19770486
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA"18606552
D013759DronabinolDronabinol results in increased expression of BPTF mRNA16597638
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of BPTF protein23352502
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BPTF mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BPTF mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BPTF mRNA21266533
D002945CisplatinCisplatin results in decreased expression of BPTF mRNA27594783
D002945CisplatinCisplatin results in increased expression of BPTF mRNA21151649
D002945CisplatinCisplatin results in increased expression of BPTF mRNA22023808
D004237DiuronDiuron results in decreased expression of BPTF mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BPTF mRNA28196854
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BPTF mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of BPTF mRNA23649840
D005839GentamicinsGentamicins results in increased expression of BPTF mRNA22061828
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA"18606552
D006220HaloperidolHaloperidol results in decreased expression of BPTF mRNA14647396
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of BPTF mRNA17183730
C544151jinfukangjinfukang results in decreased expression of BPTF mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BPTF mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BPTF mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of BPTF promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BPTF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BPTF mRNA"25554681
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of BPTF mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of BPTF mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BPTF mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of BPTF mRNA24205000
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of BPTF mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of BPTF mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in decreased expression of BPTF mRNA23608068
D011794QuercetinQuercetin results in increased expression of BPTF mRNA19729006
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of BPTF mRNA21427059
D012524SarinSarin results in increased expression of BPTF mRNA19522546
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of BPTF mRNA19244175
D012643SeleniumSelenium results in decreased expression of BPTF mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of BPTF mRNA29191790
D012834SilverSilver results in decreased expression of BPTF mRNA26551752
D020058StyreneStyrene results in decreased expression of BPTF mRNA28951217
C061133tamibarotenetamibarotene affects the expression of BPTF mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of BPTF mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of BPTF mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BPTF mRNA19770486|2135428
D013806TheophyllineTheophylline results in decreased expression of BPTF mRNA18951874
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BPTF mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BPTF mRNA25729387
D014212TretinoinTretinoin affects the expression of BPTF mRNA15498508
D014212TretinoinTretinoin results in decreased expression of BPTF mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of BPTF mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of BPTF mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of BPTF mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BPTF mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BPTF mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BPTF mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of BPTF mRNA19136453|2142705
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of BPTF mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of BPTF mRNA19244175
C111237vorinostatvorinostat results in decreased expression of BPTF mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14609955  15640247  21596426  
GO:0008094DNA-dependent ATPase activitycontributes_toIDA14609955  
GO:0008134transcription factor binding-IDA10727212  
GO:0035064methylated histone binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA10403843  
GO:0043565sequence-specific DNA binding-IMP10575013  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10727212  
GO:0001892embryonic placenta development-IEA-  
GO:0006338chromatin remodeling-IDA14609955  
GO:0006351transcription, DNA-templated-IMP14609955  
GO:0006355regulation of transcription, DNA-templated-IMP10575013  
GO:0007420brain development-IMP14609955  
GO:0007492endoderm development-IEA-  
GO:0009611response to wounding-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IMP14609955  
GO:1990090cellular response to nerve growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA27141965  
GO:0005634nucleus-IDA10403843  14609955  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-TAS7621746  
GO:0016589NURF complex-IDA20850016  
GO:0030425dendrite-IEA-  
GO:0044297cell body-IEA-  
GO:0048188Set1C/COMPASS complexcolocalizes_withIDA27141965  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28025329Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017 Jan 15)Seow WJHum Mol Genet