Gene: FANCF

2188
FAF
FA complementation group F
protein-coding
11p14.3
Ensembl:ENSG00000183161 MIM:613897 Vega:OTTHUMG00000166070 UniprotKB:Q9NPI8
NG_007425.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.724e-1 (AD)  6.946e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KBTBD60.892
ARL6IP50.877
ATF20.873
AASDHPPT0.87
GOPC0.869
RAB2A0.866
WASL0.864
SCAMP10.862
PGRMC20.862
MEAF60.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.56
OR4F29-0.502
CSAG1-0.345
MAGEA12-0.343
IL18RAP-0.341
MMP9-0.324
ANPEP-0.323
ZBTB20-0.313
KLRB1-0.311
MTRNR2L10-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of FANCF mRNA"19934314
D000082AcetaminophenAcetaminophen results in increased expression of FANCF mRNA26690555
D001151ArsenicArsenic affects the methylation of FANCF gene25304211
C006780bisphenol Abisphenol A affects the expression of FANCF mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FANCF mRNA25181051
D002104CadmiumCadmium results in decreased expression of FANCF mRNA21120746
D002220CarbamazepineCarbamazepine affects the expression of FANCF mRNA24752500
C018021cobaltous chloridecobaltous chloride results in decreased expression of FANCF mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of FANCF mRNA19549813
D004008DiclofenacDiclofenac affects the expression of FANCF mRNA24752500
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FANCF mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of FANCF mRNA20655997|2364984
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FANCF mRNA25613284
C015329lycopenelycopene results in decreased expression of FANCF mRNA16886892
D008345ManganeseManganese results in decreased expression of FANCF mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of FANCF mRNA17175027
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FANCF mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FANCF mRNA23649840
D010936Plant ExtractsPlant Extracts results in increased expression of FANCF mRNA23557933
D012402RotenoneRotenone results in increased expression of FANCF mRNA18191903
D012906SmokeSmoke results in decreased expression of FANCF mRNA21095227
D010042OuabainOuabain results in decreased expression of FANCF mRNA24124520
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FANCF mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of FANCF mRNA16870260
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FANCF mRNA28065790
D014520UrethaneUrethane results in decreased expression of FANCF mRNA28818685
D014750VincristineVincristine results in decreased expression of FANCF mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of FANCF mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI11063725  11157805  12649160  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0036297interstrand cross-link repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0043240Fanconi anaemia nuclear complex-IDA20347428  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16184554Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer. (2006 Mar 15)Kraunz KSInt J Cancer
29617660Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. (2018 Apr 3)Campbell JDCell Rep