Gene: ALDH1B1

219
ALDH5|ALDHX
aldehyde dehydrogenase 1 family member B1
protein-coding
9p13.1
Ensembl:ENSG00000137124 MIM:100670 Vega:OTTHUMG00000019938 UniprotKB:P30837
NG_012253.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.062e-1 (AD)  5.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACLY0.874
CHP10.873
MIEF10.868
METTL130.866
CLTC0.864
DLAT0.864
PRPS10.86
PSME30.86
DYNC1LI10.86
RANBP60.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.515
OR4F29-0.45
VNN3-0.388
MTRNR2L6-0.385
CSAG1-0.38
S100A12-0.371
PPBP-0.361
MTRNR2L10-0.352
MTRNR2L9-0.349
P2RY14-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein mutant form] results in increased expression of ALDH1B1 mRNA"22496397
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ALDH1B1 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH1B1 mRNA"21346803
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of ALDH1B1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ALDH1B1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1B1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ALDH1B1 mRNA"21346803
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of ALDH1B1 mRNA20932894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1B1 mRNA"27188386
D000079Acetaldehyde[ALDH1B1 protein co-treated with NAD] results in increased metabolism of Acetaldehyde7779080
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH1B1 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of ALDH1B1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ALDH1B1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH1B1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ALDH1B1 mRNA24449571
C004984apocarotenalapocarotenal results in decreased expression of ALDH1B1 mRNA17034753
C006632arsenic trioxidearsenic trioxide results in increased expression of ALDH1B1 mRNA22521957
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ALDH1B1 mRNA17998271
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDH1B1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of ALDH1B1 mRNA29275510
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ALDH1B1 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Butter] affects the expression of ALDH1B1 mRNA28487351
D002065BuspironeBuspirone results in decreased expression of ALDH1B1 mRNA24136188
D002079Butter[bisphenol A co-treated with Butter] affects the expression of ALDH1B1 mRNA28487351
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of ALDH1B1 mRNA17998271
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALDH1B1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ALDH1B1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALDH1B1 protein15650968
D002738ChloroquineChloroquine results in decreased expression of ALDH1B1 mRNA19393257
D002994Clofibrate[Clofibrate co-treated with PPARA protein mutant form] results in increased expression of ALDH1B1 mRNA22496397
D002995Clofibric AcidClofibric Acid results in increased expression of ALDH1B1 mRNA17998271
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALDH1B1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALDH1B1 mRNA24386269
D009243NAD[ALDH1B1 protein co-treated with NAD] results in increased metabolism of Acetaldehyde7779080
D009243NAD[ALDH1B1 protein co-treated with NAD] results in increased metabolism of propionaldehyde7779080
D019327Copper SulfateCopper Sulfate results in decreased expression of ALDH1B1 mRNA19549813
D003407CreosoteCreosote results in increased expression of ALDH1B1 mRNA19389177
D016572CyclosporineCyclosporine results in decreased expression of ALDH1B1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of ALDH1B1 mRNA17998271
D003907DexamethasoneDexamethasone affects the expression of ALDH1B1 mRNA15102944
D003976DiazinonDiazinon results in increased methylation of ALDH1B1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH1B1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH1B1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ALDH1B1 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of ALDH1B1 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ALDH1B1 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of ALDH1B1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of ALDH1B1 mRNA22447684
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of ALDH1B1 mRNA]22447684
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ALDH1B1 mRNA17998271
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ALDH1B1 mRNA"28433925
C014476diethyl maleatediethyl maleate results in decreased expression of ALDH1B1 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of ALDH1B1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ALDH1B1 mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of ALDH1B1 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of ALDH1B1 mRNA26924002
C118739entinostatentinostat results in increased expression of ALDH1B1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1B1 mRNA"27188386
D005015EthoxyquinEthoxyquin results in increased expression of ALDH1B1 mRNA17998271
C082360fipronilfipronil results in decreased expression of ALDH1B1 mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of ALDH1B1 mRNA23649840
C039281furanfuran results in increased expression of ALDH1B1 mRNA25539665
C039281furanfuran results in increased methylation of ALDH1B1 gene22079235
D019833GenisteinGenistein results in decreased expression of ALDH1B1 mRNA24967385
D005947GlucoseGlucose deficiency results in increased expression of ALDH1B1 protein22314686
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ALDH1B1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ALDH1B1 mRNA20044591
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ALDH1B1 mRNA21889194|2479639
C410337K 7174K 7174 results in decreased expression of ALDH1B1 mRNA24086573
C099406L 742694L 742694 affects the expression of ALDH1B1 mRNA15102944
D007854LeadLead results in decreased expression of ALDH1B1 mRNA19921347
C045463leflunomideleflunomide results in increased expression of ALDH1B1 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of ALDH1B1 mRNA24136188
D064704LevofloxacinLevofloxacin results in decreased expression of ALDH1B1 mRNA24136188
D015122MercaptopurineMercaptopurine results in decreased expression of ALDH1B1 mRNA23358152
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALDH1B1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ALDH1B1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALDH1B1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALDH1B1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ALDH1B1 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of ALDH1B1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of ALDH1B1 mRNA22110744
C012655nimesulidenimesulide results in decreased expression of ALDH1B1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ALDH1B1 protein19716841
D000073878Palm OilPalm Oil affects the expression of ALDH1B1 mRNA19680557
C016030pantogabpantogab results in decreased expression of ALDH1B1 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ALDH1B1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ALDH1B1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ALDH1B1 mRNA17681415
C011272perfosfamideALDH1B1 protein affects the susceptibility to perfosfamide18473730
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of ALDH1B1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ALDH1B1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ALDH1B1 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of ALDH1B1 mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ALDH1B1 mRNA17998271
C005556propionaldehyde[ALDH1B1 protein co-treated with NAD] results in increased metabolism of propionaldehyde7779080
D011794QuercetinQuercetin results in decreased expression of ALDH1B1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of ALDH1B1 mRNA]22447684
C059514resveratrolresveratrol results in decreased expression of ALDH1B1 mRNA18930334
D012643SeleniumSelenium deficiency results in increased expression of ALDH1B1 mRNA16170372
D012834SilverSilver results in decreased expression of ALDH1B1 mRNA26014281
D012834SilverSilver results in decreased expression of ALDH1B1 mRNA27131904
C016104sodium bichromatesodium bichromate affects the expression of ALDH1B1 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of ALDH1B1 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of ALDH1B1 mRNA27862939
D012999SomanSoman results in decreased expression of ALDH1B1 mRNA19281266
D013148SpironolactoneSpironolactone results in increased expression of ALDH1B1 mRNA17998271
C013698tallowtallow affects the expression of ALDH1B1 mRNA19680557
C061133tamibarotenetamibarotene affects the expression of ALDH1B1 mRNA15498508
D013629TamoxifenTamoxifen results in decreased expression of ALDH1B1 mRNA25123088
C004648testosterone enanthatetestosterone enanthate affects the expression of ALDH1B1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH1B1 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH1B1 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ALDH1B1 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in increased expression of ALDH1B1 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH1B1 mRNA17998271|2386450
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALDH1B1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDH1B1 mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of ALDH1B1 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ALDH1B1 protein22609517
C066340tolcaponetolcapone binds to ALDH1B1 protein19783845
D014212TretinoinTretinoin affects the expression of ALDH1B1 mRNA15498508
D014241TrichloroethyleneTrichloroethylene results in increased expression of ALDH1B1 mRNA19254012
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALDH1B1 mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of ALDH1B1 mRNA24136188
D014520UrethaneUrethane results in decreased expression of ALDH1B1 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of ALDH1B1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ALDH1B1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ALDH1B1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ALDH1B1 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ALDH1B1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ALDH1B1 mRNA20566332
C029297vinylidene chloridevinylidene chloride results in increased expression of ALDH1B1 mRNA26682919
C574123walrycin Awalrycin A results in increased expression of ALDH1B1 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004029aldehyde dehydrogenase (NAD) activity-IBA21873635  
GO:0004029aldehyde dehydrogenase (NAD) activity-TAS-  
GO:0043878glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity-IEA-  
GO:0051287NAD binding-ISS12693930  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-NAS1306115  
GO:0006068ethanol catabolic process-IEA-  
GO:0006069ethanol oxidation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa00330Arginine and proline metabolism
hsa00340Histidine metabolism
hsa00380Tryptophan metabolism
hsa00410beta-Alanine metabolism
hsa00561Glycerolipid metabolism
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology
28594837Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. (2017)Way MJPLoS One