Gene: FAP

2191
DPPIV|FAPA|FAPalpha|SIMP
fibroblast activation protein alpha
protein-coding
2q24.2
Ensembl:ENSG00000078098 MIM:600403 Vega:OTTHUMG00000153890 UniprotKB:Q12884
NG_027991.1
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.262e-1 (AD)  6.850e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGBD10.792
ZNF2300.772
ST3GAL60.769
WDR190.756
SETDB20.749
ZNF1820.738
ORC20.737
ZNF300.734
RFC40.728
LGALS80.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIO2-0.445
LYPD1-0.443
MDFI-0.402
MMD2-0.399
AQP5-0.394
WNT7B-0.385
TSPAN12-0.38
BTBD17-0.364
NKX6-1-0.36
PLA2G5-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAP gene27153756
C083013alanylproline-4-nitroanilideFAP protein results in increased cleavage of alanylproline-4-nitroanilide17287297|1918848
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FAP mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of FAP mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of FAP mRNA]12205029
C006632arsenic trioxidearsenic trioxide results in increased expression of FAP mRNA25258189
C547126AZM551248AZM551248 results in increased expression of FAP mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAP mRNA27195522
D004958EstradiolEstradiol results in increased expression of FAP mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FAP mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAP mRNA28628672
C006780bisphenol Abisphenol A affects the expression of FAP mRNA25181051
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FAP mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAP mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of FAP mRNA18042831|2501614
D002117CalcitriolCalcitriol results in decreased expression of FAP mRNA26485663
D004237DiuronDiuron results in decreased expression of FAP mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FAP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAP mRNA17942748
C039281furanfuran results in increased expression of FAP mRNA27387713
C042892glycylproline 4-nitroanilideFAP protein results in increased cleavage of glycylproline 4-nitroanilide17287297|1918848
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FAP mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FAP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAP mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAP mRNA24796395
D008713MethimazoleMethimazole results in decreased expression of FAP mRNA17403546
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAP mRNA26011545
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of FAP mRNA19812364
D000073878Palm OilPalm Oil results in decreased expression of FAP mRNA18042831
C494474perchlorateperchlorate results in decreased expression of FAP mRNA17403546
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of FAP mRNA23602845
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FAP mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of FAP mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of FAP mRNA17403546
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of FAP mRNA14699072
D015842Serine Proteinase InhibitorsSerine Proteinase Inhibitors inhibits the reaction [FAP protein results in increased cleavage of FGF21 protein]26797127
D015842Serine Proteinase InhibitorsSerine Proteinase Inhibitors results in decreased activity of FAP protein26797127
D015842Serine Proteinase InhibitorsSerine Proteinase Inhibitors results in decreased activity of FAP protein26797127
D015842Serine Proteinase InhibitorsSerine Proteinase Inhibitors results in decreased activity of FAP protein26797127
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FAP mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of FAP mRNA22714537
D013629TamoxifenTamoxifen affects the expression of FAP mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAP mRNA17942748
D014635Valproic AcidValproic Acid results in decreased methylation of FAP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FAP mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI17317851  
GO:0004175endopeptidase activity-IDA17317851  
GO:0004222metalloendopeptidase activity-TAS9065413  
GO:0004252serine-type endopeptidase activity-IDA10593948  
GO:0005178integrin binding-IPI10455171  
GO:0005515protein binding-IPI16651416  21314817  
GO:0008233peptidase activity-IDA9688278  10455171  
GO:0008236serine-type peptidase activity-IDA16651416  
GO:0008236serine-type peptidase activity-IMP9065413  
GO:0008236serine-type peptidase activity-NAS7911242  9247085  
GO:0008239dipeptidyl-peptidase activity-IDA10593948  
GO:0008239dipeptidyl-peptidase activity-NAS7911242  
GO:0042803protein homodimerization activity-IDA10455171  
GO:0042803protein homodimerization activity-NAS9247085  
GO:0046983protein dimerization activity-NAS9065413  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006508proteolysis-IDA10455171  
GO:0007155cell adhesion-IEA-  
GO:0010710regulation of collagen catabolic process-IDA10455171  
GO:0010716negative regulation of extracellular matrix disassembly-IDA16651416  
GO:0043542endothelial cell migration-IDA16651416  
GO:0051603proteolysis involved in cellular protein catabolic process-IDA10593948  
GO:0051917regulation of fibrinolysis-IC17317851  
GO:0060244negative regulation of cell proliferation involved in contact inhibition-ISS-  
GO:0071158positive regulation of cell cycle arrest-ISS-  
GO:0071850mitotic cell cycle arrest-ISS-  
GO:0097325melanocyte proliferation-ISS-  
GO:1900119positive regulation of execution phase of apoptosis-ISS-  
GO:1902362melanocyte apoptotic process-ISS-  
GO:1903054negative regulation of extracellular matrix organization-IDA10455171  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA17317851  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA10593948  
GO:0005886plasma membrane-NAS10455171  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-ISS-  
GO:0016021integral component of membrane-NAS9065413  
GO:0030027lamellipodium-IDA9065413  16651416  
GO:0031258lamellipodium membrane-IEA-  
GO:0032587ruffle membrane-NAS10455171  
GO:0045177apical part of cell-IEA-  
GO:0045178basal part of cell-IEA-  
GO:0071438invadopodium membrane-IDA10455171  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12670518Epidemiology of pancreatic cancer: an overview. (2003)Ghadirian PCancer Detect Prev
10359544Colorectal cancer: molecules and populations. (1999 Jun 2)Potter JDJ Natl Cancer Inst
15885054Bone mineral density in familial amyloid polyneuropathy and in other neuromuscular disorders. (2005 Jun)Conceicao IMEur J Neurol
23970361APC germline mutations in families with familial adenomatous polyposis. (2013 Nov)De Queiroz Rossanese LBOncol Rep
12048974[Etiopathogenic factors in colorectal cancer. Genetic and clinical features (first of 2 parts)]. (2002 Mar-Apr)Casimiro CNutr Hosp
10675494Both HPV and carcinogen contribute to the development of resistance to apoptosis during oral carcinogenesis. (2000 Mar)Itakura MInt J Oncol
23162625A case of multiple primary malignancies and investigation of family history. (2012 Nov)Huang XYOncol Lett
7982235Glutathione S-transferase Mu phenotype in patients with familial adenomatous polyposis and in unaffected controls. (1994)Spigelman ADCancer Detect Prev
28246467Familial pancreatic cancer: Concept, management and issues. (2017 Feb 14)Matsubayashi HWorld J Gastroenterol