Gene: FAT1

2195
CDHF7|CDHR8|FAT|ME5|hFat1
FAT atypical cadherin 1
protein-coding
4q35.2
Ensembl:ENSG00000083857 MIM:600976 Vega:OTTHUMG00000160320 UniprotKB:Q14517
NG_046994.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.015e-1 (AD)  7.072e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6553017chr4:186660322 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELOVL20.907
HEPH0.9
PPARA0.89
LRP40.889
SLC4A40.888
NTRK20.885
ATP13A40.884
ACSBG10.882
HEPACAM0.88
SPON10.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.395
NRG1-0.389
SULT2B1-0.355
DPP4-0.354
CD163L1-0.353
TRABD2A-0.343
FHL2-0.341
HS3ST2-0.341
SMPX-0.336
OR51Q1-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FAT1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FAT1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of FAT1 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FAT1 mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of FAT1 mRNA16460773
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FAT1 mRNA"25380136
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of FAT1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of FAT1 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of FAT1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FAT1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAT1 mRNA27153756
D000638AmiodaroneAmiodarone affects the expression of FAT1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FAT1 mRNA16483693
C006632arsenic trioxide[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of FAT1 mRNA25555879
C006632arsenic trioxidearsenic trioxide results in increased expression of FAT1 mRNA25555879
D001205Ascorbic Acid[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of FAT1 mRNA25555879
D001205Ascorbic AcidAscorbic Acid results in increased expression of FAT1 mRNA25555879
D001280AtrazineAtrazine results in decreased expression of FAT1 mRNA23358194|2592983
D001280AtrazineAtrazine results in increased expression of FAT1 mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAT1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAT1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAT1 mRNA19770486|2261060
D004958EstradiolEstradiol results in decreased expression of FAT1 mRNA21185374
D004958EstradiolEstradiol results in increased expression of FAT1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of FAT1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAT1 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FAT1 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of FAT1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of FAT1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAT1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FAT1 mRNA28628672
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of FAT1 mRNA16460773
D002065BuspironeBuspirone results in decreased expression of FAT1 mRNA24136188
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA12634122
C100187chloropicrinchloropicrin results in decreased expression of FAT1 mRNA26352163|2847649
D002746ChlorpromazineChlorpromazine affects the expression of FAT1 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FAT1 gene20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA12634122
D002994ClofibrateClofibrate results in decreased expression of FAT1 mRNA23811191
D002995Clofibric AcidClofibric Acid affects the expression of FAT1 mRNA17602206
D019327Copper SulfateCopper Sulfate results in increased expression of FAT1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of FAT1 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of FAT1 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of FAT1 mRNA20106945|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAT1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FAT1 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in increased expression of FAT1 mRNA23656968
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FAT1 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FAT1 mRNA17379624
C000944dicrotophosdicrotophos results in increased expression of FAT1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of FAT1 mRNA18042831
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FAT1 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of FAT1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FAT1 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FAT1 mRNA25380136
D004221DisulfiramDisulfiram results in decreased expression of FAT1 mRNA20530235
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of FAT1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FAT1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FAT1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FAT1 mRNA17557909
C540355fenamidonefenamidone results in increased expression of FAT1 mRNA27029645
D005485FlutamideFlutamide results in decreased expression of FAT1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of FAT1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FAT1 gene20938992
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of FAT1 gene28505145
D019833GenisteinGenistein results in decreased expression of FAT1 mRNA12075121
D017313FenretinideFenretinide results in increased expression of FAT1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAT1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FAT1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FAT1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FAT1 mRNA28628672
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA12634122
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FAT1 gene20938992
D016685MitomycinFAT1 protein affects the susceptibility to Mitomycin16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of FAT1 mRNA22087261
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of FAT1 mRNA11494140
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FAT1 mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of FAT1 mRNA19812364
D009538NicotineNicotine results in increased expression of FAT1 mRNA16949557
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of FAT1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of FAT1 mRNA19716841
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FAT1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FAT1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of FAT1 mRNA18042831
D010269ParaquatParaquat affects the expression of FAT1 mRNA25064622
D052638Particulate MatterParticulate Matter results in decreased expression of FAT1 mRNA22178795
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAT1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of FAT1 mRNA19482888
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FAT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FAT1 mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in increased expression of FAT1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of FAT1 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of FAT1 mRNA23274088
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of FAT1 mRNA16014031
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of FAT1 protein16014031
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FAT1 mRNA27029645
C030984pyrenepyrene results in increased expression of FAT1 mRNA23656968
D011794QuercetinQuercetin results in decreased expression of FAT1 protein19207037
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA12634122
C105686SU 5402SU 5402 affects the expression of FAT1 mRNA15298682
C061133tamibarotenetamibarotene affects the expression of FAT1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAT1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAT1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAT1 mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of FAT1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAT1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAT1 mRNA21215274
D013752TetracyclineTetracycline affects the expression of FAT1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of FAT1 mRNA25064622
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of FAT1 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of FAT1 mRNA23411599
D013893ThiramThiram results in decreased expression of FAT1 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FAT1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FAT1 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FAT1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FAT1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FAT1 mRNA15498508|2372400
D014635Valproic AcidValproic Acid affects the expression of FAT1 mRNA25064622
D014635Valproic AcidValproic Acid results in decreased expression of FAT1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of FAT1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FAT1 mRNA23179753
C029297vinylidene chloridevinylidene chloride results in increased expression of FAT1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16979624  19131340  
GO ID GO Term Qualifier Evidence PubMed
GO:0007015actin filament organization-ISS-  
GO:0007155cell adhesion-TAS8586420  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007163establishment or maintenance of cell polarity-ISS-  
GO:0007267cell-cell signaling-TAS8586420  
GO:0009653anatomical structure morphogenesis-TAS8586420  
GO:0016477cell migration-ISS-  
GO:0098609cell-cell adhesion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15922730  
GO:0005886plasma membrane-IDA15922730  
GO:0005887integral component of plasma membrane-TAS8586420  
GO:0005911cell-cell junction-IDA15148305  
GO:0005925focal adhesion-HDA21423176  
GO:0030027lamellipodium-IEA-  
GO:0030175filopodium-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA15922730  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29302581Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure. (2017 Dec)Choi JRJ Cancer Prev
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
26900290Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. (2016 Feb 21)Sasaki YWorld J Gastroenterol
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology