Gene: FAT2

2196
CDHF8|CDHR9|HFAT2|MEGF1|SCA45
FAT atypical cadherin 2
protein-coding
5q33.1
Ensembl:ENSG00000086570 MIM:604269 Vega:OTTHUMG00000130126 UniprotKB:Q9NYQ8
NG_046979.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.835e-1 (AD)  3.220e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMC20.801
GPR10.79
SAG0.788
GPR1010.788
DRD30.786
AMBN0.783
OTOF0.779
ENTHD10.77
COCH0.769
DGKK0.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1A1-0.397
CDKN2C-0.354
RNF182-0.279
ASCL1-0.279
ZIC2-0.26
NANOS3-0.25
HPSE2-0.237
CTSH-0.233
HSPB6-0.232
FOXJ1-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FAT2 mRNA"28973690
D020106AcrylamideAcrylamide results in decreased expression of FAT2 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FAT2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAT2 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of FAT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAT2 gene28505145
C031180chrysenechrysene results in increased expression of FAT2 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of FAT2 mRNA17553155
D003976DiazinonDiazinon results in increased expression of FAT2 mRNA29108742
D004041Dietary FatsDietary Fats results in increased expression of FAT2 mRNA25016146
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FAT2 mRNA27776689
D019833GenisteinGenistein results in decreased expression of FAT2 mRNA26865667
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of FAT2 protein17337753
D009538NicotineNicotine results in increased expression of FAT2 mRNA23825647
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of FAT2 mRNA17616710
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FAT2 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FAT2 mRNA16221955
C006253pirinixic acidpirinixic acid results in increased expression of FAT2 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of FAT2 mRNA18037150
D011374ProgesteroneProgesterone results in decreased expression of FAT2 mRNA22238285
D018038Sodium SeleniteSodium Selenite results in decreased expression of FAT2 mRNA18175754
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of FAT2 mRNA28973375
D014520UrethaneUrethane results in decreased expression of FAT2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-ISS-  
GO:0010631epithelial cell migration-IMP17900869  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0005913cell-cell adherens junction-IDA17900869  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis