Gene: CCNY

219771
C10orf9|CBCP1|CCNX|CFP1
cyclin Y
protein-coding
10p11.21
Ensembl:ENSG00000108100 MIM:612786 Vega:OTTHUMG00000017955 UniprotKB:Q8ND76
NC_000010.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.027e-1 (AD)  5.439e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNB10.959
CALM10.949
RNF110.945
WSB20.937
PPP2R5C0.928
IDS0.928
ARF30.925
TATDN20.924
RAB6A0.921
MAPK8IP10.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.794
OR4F29-0.763
S100A12-0.33
CSAG1-0.3
KCNJ15-0.285
CXCR2-0.281
IL18RAP-0.279
FCGR3B-0.278
CST7-0.274
IL1R2-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCNY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCNY mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CCNY mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CCNY mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNY mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCNY mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CCNY mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CCNY mRNA25979313
D002737ChloropreneChloroprene results in increased expression of CCNY mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNY gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CCNY mRNA19320972
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of CCNY protein23811945
D002945CisplatinCisplatin results in decreased expression of CCNY mRNA19561079
D004026DieldrinDieldrin affects the expression of CCNY mRNA23041725
D004317DoxorubicinDoxorubicin results in increased expression of CCNY mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCNY mRNA22079256
D018120FinasterideFinasteride results in increased expression of CCNY mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNY gene20938992
D005839GentamicinsGentamicins results in increased expression of CCNY mRNA22061828
D017313FenretinideFenretinide results in increased expression of CCNY mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CCNY mRNA21179406
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CCNY mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CCNY gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCNY mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCNY mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCNY mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of CCNY mRNA26516004
D010634PhenobarbitalPhenobarbital affects the expression of CCNY mRNA23091169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCNY mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CCNY mRNA22079256
C010327salinomycinsalinomycin results in decreased expression of CCNY mRNA19682730
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CCNY mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCNY mRNA22298810
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCNY mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CCNY mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNY mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of CCNY mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCNY gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CCNY mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15324660  17353931  19524571  20059949  24794231  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IDA19524571  20059949  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IDA20059949  
GO:0016055Wnt signaling pathway-IEA-  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IDA19524571  20059949  
GO:0051301cell division-IEA-  
GO:0060828regulation of canonical Wnt signaling pathway-IDA20059949  
GO ID GO Term Qualifier Evidence PubMed
GO:0000308cytoplasmic cyclin-dependent protein kinase holoenzyme complex-IDA19524571  20059949  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA19524571  20059949  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19953089Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease. (2010 May)van der Heide FAm J Gastroenterol
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J