Gene: RTKN2

219790
PLEKHK1|bA531F24.1
rhotekin 2
protein-coding
10q21.2
Ensembl:ENSG00000182010 Vega:OTTHUMG00000018299 UniprotKB:Q8IZC4
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.862e-1 (AD)  6.271e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTH2R0.868
STAT40.842
SDR16C50.84
LRFN50.839
ZNF3650.838
TIAM20.836
MLIP0.835
STXBP5L0.835
KCNV10.832
DCBLD10.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.539
BCL7C-0.538
MYL3-0.535
COPZ2-0.524
ACAP1-0.518
AAMDC-0.516
MDFI-0.507
RAB13-0.505
ROM1-0.499
TSPO-0.491

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of RTKN2 mRNA"22952946
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTKN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTKN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RTKN2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RTKN2 mRNA21641981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RTKN2 mRNA21632981
C006780bisphenol Abisphenol A affects the expression of RTKN2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RTKN2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RTKN2 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RTKN2 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of RTKN2 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of RTKN2 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of RTKN2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RTKN2 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RTKN2 mRNA22079256
D004397FonofosFonofos results in increased methylation of RTKN2 promoter22847954
C492448ICG 001ICG 001 results in decreased expression of RTKN2 mRNA26191083
C045463leflunomideleflunomide results in decreased expression of RTKN2 mRNA28988120
D008694MethamphetamineMethamphetamine results in decreased expression of RTKN2 mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of RTKN2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RTKN2 mRNA23179753
C523799MRK 003RTKN2 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of RTKN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RTKN2 mRNA"25554681
D009532NickelNickel results in increased expression of RTKN2 mRNA24768652|2558310
D010126OzoneOzone results in decreased expression of RTKN2 mRNA17095637
D010126OzoneOzone results in decreased expression of RTKN2 mRNA28623178
D010278ParathionParathion results in increased methylation of RTKN2 promoter22847954
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of RTKN2 mRNA26678675
C006253pirinixic acidpirinixic acid results in increased expression of RTKN2 mRNA20813756
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of RTKN2 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RTKN2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RTKN2 mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in increased expression of RTKN2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RTKN2 mRNA25895662
C012568terbufosterbufos results in increased methylation of RTKN2 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RTKN2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RTKN2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTKN2 mRNA17884332
C009495titanium dioxidetitanium dioxide results in decreased expression of RTKN2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of RTKN2 mRNA18230668
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTKN2 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of RTKN2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of RTKN2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RTKN2 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of RTKN2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of RTKN2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RTKN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017049GTP-Rho binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000281mitotic cytokinesis-IBA21873635  
GO:0000915actomyosin contractile ring assembly-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0030097hemopoiesis-IBA21873635  
GO:0030097hemopoiesis-IEA-  
GO:0030865cortical cytoskeleton organization-IBA21873635  
GO:0031106septin ring organization-IBA21873635  
GO:1904498protein localization to mitotic actomyosin contractile ring-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005826actomyosin contractile ring-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics