Gene: EFEMP1

2202
DHRD|DRAD|FBLN3|FBNL|FIBL-3|MLVT|MTLV|S1-5
EGF containing fibulin extracellular matrix protein 1
protein-coding
2p16.1
Ensembl:ENSG00000115380 MIM:601548 Vega:OTTHUMG00000129343 UniprotKB:Q12805
NG_009098.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  2.775e-1 (ND)   (Frontal_Cortex)
3.229e-1 (AD)  1.676e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2033316chr2:55913396 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMPR1B0.883
GJA10.875
NPAS30.872
METTL7A0.855
ARHGEF260.852
AGT0.848
WLS0.847
SPON10.846
STK330.846
SOX90.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.451
MCHR1-0.445
CACNA1F-0.435
TYRP1-0.432
PRSS12-0.427
ADRA1D-0.426
PAQR9-0.426
DUSP27-0.425
GABRG3-0.423
RTP1-0.421

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EFEMP1 mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFEMP1 mRNA"19167446
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of EFEMP1 mRNA22193206
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EFEMP1 mRNA"12376462
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of EFEMP1 mRNA"20206263
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of EFEMP1 mRNA"24172598
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IFNG protein results in increased expression of EFEMP1 mRNA]19208748
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of EFEMP1 mRNA19208748
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EFEMP1 mRNA17562736
D000447AldehydesAldehydes results in increased expression of EFEMP1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EFEMP1 mRNA16483693
D018943AnthracyclinesEFEMP1 protein affects the susceptibility to Anthracyclines19115204
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EFEMP1 mRNA24449571
C519728archazolid Barchazolid B results in decreased expression of EFEMP1 mRNA25218289
D001379AzathioprineAzathioprine results in increased expression of EFEMP1 mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EFEMP1 mRNA19770486
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EFEMP1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of EFEMP1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EFEMP1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of EFEMP1 mRNA19619570|2118537
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of EFEMP1 mRNA]21185374
D004958EstradiolEstradiol results in increased expression of EFEMP1 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EFEMP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of EFEMP1 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of EFEMP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EFEMP1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EFEMP1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of EFEMP1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of EFEMP1 mRNA17484886
C039671ciglitazoneciglitazone results in decreased expression of EFEMP1 mRNA22193206
C018021cobaltous chloridecobaltous chloride results in decreased expression of EFEMP1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased secretion of EFEMP1 protein22079246
D003300Copper[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of EFEMP1 mRNA20971185
D003345CorticosteroneCorticosterone results in increased expression of EFEMP1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFEMP1 mRNA"19167446
C030973cupric oxidecupric oxide results in decreased expression of EFEMP1 mRNA22077320
D000069439DasatinibDasatinib results in increased expression of EFEMP1 mRNA20579391
C014347decitabinedecitabine affects the methylation of EFEMP1 promoter17671114
D003907DexamethasoneDexamethasone results in decreased expression of EFEMP1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EFEMP1 mRNA28628672
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EFEMP1 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of EFEMP1 mRNA20705681
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EFEMP1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of EFEMP1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of EFEMP1 mRNA24535843
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EFEMP1 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EFEMP1 mRNA"12376462
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of EFEMP1 mRNA22193206
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA24690739
D004237DiuronDiuron results in decreased expression of EFEMP1 mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EFEMP1 mRNA17557909
C540355fenamidonefenamidone results in increased expression of EFEMP1 mRNA27029645
C039281furanfuran results in increased expression of EFEMP1 mRNA27387713
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of EFEMP1 mRNA19192274
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of EFEMP1 mRNA"26377693
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EFEMP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EFEMP1 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of EFEMP1 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EFEMP1 mRNA24796395
D007840LatexLatex analog results in decreased expression of EFEMP1 mRNA24768652
D008154LucanthoneLucanthone results in decreased expression of EFEMP1 mRNA21148553
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EFEMP1 mRNA20823114
D015122MercaptopurineMercaptopurine results in increased expression of EFEMP1 mRNA23358152
D008727MethotrexateMethotrexate results in increased expression of EFEMP1 mRNA19192274
D008775MethylprednisoloneMethylprednisolone results in increased expression of EFEMP1 mRNA19192274
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EFEMP1 mRNA26924002
C523799MRK 003MRK 003 results in decreased expression of EFEMP1 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFEMP1 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EFEMP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EFEMP1 mRNA"25554681|2562005
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of EFEMP1 mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of EFEMP1 mRNA23665939
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of EFEMP1 mRNA20705681
D000073878Palm OilPalm Oil results in decreased expression of EFEMP1 mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of EFEMP1 mRNA22178795
C046012pentanalpentanal results in increased expression of EFEMP1 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of EFEMP1 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of EFEMP1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of EFEMP1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of EFEMP1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of EFEMP1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EFEMP1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of EFEMP1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of EFEMP1 mRNA23608068
D011239PrednisolonePrednisolone results in increased expression of EFEMP1 mRNA19192274
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of EFEMP1 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of EFEMP1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of EFEMP1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EFEMP1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of EFEMP1 mRNA15309432
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of EFEMP1 mRNA14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of EFEMP1 mRNA]21185374
C059514resveratrolresveratrol affects the secretion of EFEMP1 protein24802182
C078903seocalcitolseocalcitol results in decreased expression of EFEMP1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EFEMP1 mRNA25895662
D013629TamoxifenTamoxifen affects the expression of EFEMP1 mRNA14699072
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EFEMP1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFEMP1 mRNA12377990|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EFEMP1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFEMP1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFEMP1 mRNA22808131
C009495titanium dioxidetitanium dioxide results in decreased expression of EFEMP1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EFEMP1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EFEMP1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of EFEMP1 mRNA23830798
D014212TretinoinTretinoin results in increased expression of EFEMP1 mRNA21934132
C011559tributyltintributyltin results in increased expression of EFEMP1 mRNA21683754
C012589trichostatin Atrichostatin A results in increased expression of EFEMP1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EFEMP1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFEMP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EFEMP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of EFEMP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EFEMP1 mRNA23179753|2352703
D014635Valproic AcidValproic Acid results in increased expression of EFEMP1 mRNA24896083
D014640VancomycinVancomycin results in decreased expression of EFEMP1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of EFEMP1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of EFEMP1 mRNA26682919
C111237vorinostatvorinostat results in increased expression of EFEMP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005006epidermal growth factor-activated receptor activity-IDA19804359  
GO:0005154epidermal growth factor receptor binding-IDA19804359  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI12620389  16189514  16713569  18985028  19275936  25416956  
25910212  26871637  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IDA20005202  
GO:0007173epidermal growth factor receptor signaling pathway-IDA19804359  
GO:0007601visual perception-TAS10369267  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IDA19804359  
GO:0032331negative regulation of chondrocyte differentiation-IDA20005202  
GO:0043010camera-type eye development-IEP25406291  
GO:0048048embryonic eye morphogenesis-IEP25406291  
GO:0048050post-embryonic eye morphogenesis-IEP25406291  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005615extracellular space-IDA20005202  
GO:0031012extracellular matrix-TAS10369267  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal