Gene: HEPACAM

220296
GlialCAM|MLC2A|MLC2B
hepatic and glial cell adhesion molecule
protein-coding
11q24.2
Ensembl:ENSG00000165478 MIM:611642 Vega:OTTHUMG00000165938 UniprotKB:Q14CZ8
NG_029603.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.707e-1 (AD)  1.381e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTRK20.918
GJA10.903
SPON10.902
ATP13A40.895
METTL7A0.891
LRP40.89
ACSBG10.887
PBXIP10.883
SLC1A30.881
ZNRF30.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.401
OR4F29-0.385
SULT2B1-0.383
GAL-0.365
QRFPR-0.342
MCHR1-0.328
CACNA1F-0.327
TRABD2A-0.327
AKR1C2-0.326
KLK8-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HEPACAM mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HEPACAM mRNA26238291
C006780bisphenol Abisphenol A results in decreased expression of HEPACAM mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of HEPACAM protein28903499
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of HEPACAM mRNA24763279
D016572CyclosporineCyclosporine results in decreased expression of HEPACAM mRNA20106945|2163298
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HEPACAM mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of HEPACAM mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HEPACAM mRNA21592394
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of HEPACAM mRNA24763279
D007854LeadLead affects the expression of HEPACAM mRNA28903495
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HEPACAM protein26879310
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HEPACAM mRNA25895662
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HEPACAM mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HEPACAM mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HEPACAM mRNA20106945|2163298
C009495titanium dioxidetitanium dioxide results in decreased expression of HEPACAM mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of HEPACAM mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HEPACAM mRNA20133372
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HEPACAM mRNA"26179874
D014520UrethaneUrethane results in decreased expression of HEPACAM mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of HEPACAM gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HEPACAM gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007050cell cycle arrest-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0034613cellular protein localization-IEA-  
GO:0040008regulation of growth-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005911cell-cell junction-IDA21419380  
GO:0016021integral component of membrane-IEA-  
GO:0030424axon-IDA21419380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25110502Effects of smoking cessation on gene expression in human leukocytes of chronic smoker. (2014 Jul)Kim SJPsychiatry Investig