Gene: FCAR

2204
CD89|CTB-61M7.2|FcalphaRI
Fc fragment of IgA receptor
protein-coding
19q13.42
Ensembl:ENSG00000186431 MIM:147045 Vega:OTTHUMG00000065936 UniprotKB:P24071
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.578e-1 (AD)  7.811e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FPR20.805
FPR10.775
BCL2A10.764
PSTPIP20.749
LILRA50.747
PTPRC0.747
VNN20.735
FCGR2A0.732
TREML20.724
CSF2RB0.723

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL11A-0.479
ANKRD34A-0.479
RTN4R-0.477
NEUROD6-0.476
DLK2-0.473
TMEM179-0.472
MAGIX-0.468
FAM57B-0.466
MARCH4-0.461
LRTM2-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FCAR mRNA"23146750
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FCAR mRNA24449571
D001564Benzo(a)pyreneAHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA]21911031
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCAR mRNA20064835|2191103
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCAR protein21911031
D001564Benzo(a)pyreneDactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA]21911031
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCAR mRNA21911031
C006780bisphenol Abisphenol A results in decreased expression of FCAR mRNA25181051
D003300CopperCopper deficiency results in increased expression of FCAR mRNA26033743
D003609DactinomycinDactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA]21911031
D002945CisplatinCisplatin results in increased expression of FCAR mRNA27594783
D004391DustDust results in increased expression of FCAR mRNA17805423
C082360fipronilfipronil results in decreased expression of FCAR mRNA27091632
C546771gardiquimodgardiquimod results in decreased expression of FCAR mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FCAR mRNA]28003376
D008748MethylcholanthreneMethylcholanthrene results in increased expression of FCAR mRNA21911031
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FCAR mRNA]28003376
C016766sulforafansulforafan results in increased expression of FCAR mRNA26833863

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019862IgA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS10835685  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2258698  
GO:0035579specific granule membrane-TAS-  
GO:0070821tertiary granule membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26812355RNA-sequencing study of peripheral blood monocytes in chronic periodontitis. (2016 May 1)Liu YZGene