Gene: LRRC63

220416
-
leucine rich repeat containing 63
protein-coding
13q14.13
Ensembl:ENSG00000173988 Vega:OTTHUMG00000016866 UniprotKB:Q05C16
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs912784chr13:46211386 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAH170.902
ST180.881
LGR50.88
LRP20.864
NIPAL40.856
C21orf910.855
SLC45A30.852
SH3TC20.851
GALNT60.85
PIEZO20.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.432
PRTN3-0.393
CHRNA2-0.387
NEUROD1-0.387
PCDH8-0.387
POU3F1-0.383
LTK-0.383
SLC29A4-0.377
GPR153-0.377
MGAT5B-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of LRRC63 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LRRC63 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LRRC63 mRNA24982889
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of LRRC63 mRNA26033743
D003300CopperCopper deficiency results in increased expression of LRRC63 mRNA26033743
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of LRRC63 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of LRRC63 mRNA26033743
C069837fullerene C60fullerene C60 results in decreased expression of LRRC63 mRNA19167457
C028007nickel monoxidenickel monoxide results in decreased expression of LRRC63 mRNA19167457
C428725pyridabenpyridaben results in decreased expression of LRRC63 mRNA22563483

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal