Gene: FCER1A

2205
FCE1A|FcERI
Fc fragment of IgE receptor Ia
protein-coding
1q23.2
Ensembl:ENSG00000179639 MIM:147140 Vega:OTTHUMG00000037176 UniprotKB:P12319
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.145e-1 (AD)  9.539e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VGLL30.706
SLC13A40.7
SLC22A80.692
OGN0.675
ESM10.664
ITIH30.663
CDC20B0.646
OR51E20.64
NTF30.632
MYOCD0.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR6A1-0.288
NTN5-0.266
KRTAP5-1-0.265
DOK7-0.262
PNPLA7-0.258
NR1D1-0.244
CNKSR1-0.24
SLC34A3-0.239
ZFHX2-0.234
DNASE1L2-0.234

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00043OmalizumabBiotechDrug242138-07-4Approved|InvestigationalTarget
DB00895Benzylpenicilloyl PolylysineSmall Molecule31855-75-1ApprovedTarget
DB05797TNX-901Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FCER1A mRNA"18648102
C010395acetylsalicylic acid lysinateacetylsalicylic acid lysinate inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]19767084
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FCER1A mRNA16483693
D001241AspirinAspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]19767084
D001241AspirinFCER1A gene SNP affects the susceptibility to Aspirin20485159
D001241AspirinFCER1A polymorphism affects the susceptibility to Aspirin17125826
D016589AstemizoleAstemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]9088877
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCER1A mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of FCER1A mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCER1A mRNA23735875
C006780bisphenol Abisphenol A results in decreased expression of FCER1A mRNA25181051
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of FCER1A mRNA21852083
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of FCER1A mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FCER1A mRNA15212814
D005419FlavonoidsFlavonoids results in increased expression of FCER1A mRNA18035473
C039281furanfuran results in increased expression of FCER1A mRNA27387713
C010176halofuginonehalofuginone results in increased expression of FCER1A mRNA17180598
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of FCER1A mRNA15159207
D006632HistamineFCER1A polymorphism affects the secretion of Histamine17125826
D020910KetorolacKetorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]19767084
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of FCER1A mRNA15120970
C523799MRK 003FCER1A results in increased susceptibility to MRK 00319903844
C028007nickel monoxidenickel monoxide results in increased expression of FCER1A mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 protein]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF protein]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]"16818790
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]"16818790
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of FCER1A mRNA19176365
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of FCER1A mRNA19176365
C059514resveratrolresveratrol results in decreased expression of FCER1A mRNA25280562
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of FCER1A mRNA21852083
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]16818790
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]16818790
D012524SarinSarin results in increased expression of FCER1A mRNA19522546
D018038Sodium SeleniteSodium Selenite results in increased expression of FCER1A mRNA18175754
C106448tecastemizoletecastemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]9088877
D024505TocopherolsTocopherols results in increased expression of FCER1A mRNA17056531
D014635Valproic AcidValproic Acid results in decreased methylation of FCER1A gene29154799
D014635Valproic AcidValproic Acid affects the expression of FCER1A mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FCER1A gene25560391
D015032Zinc"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]"16818790
D015032ZincZinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]16818790
D015032ZincZinc promotes the reaction [FCER1A protein results in increased expression of IL6 mRNA]16818790
D015032ZincZinc promotes the reaction [FCER1A protein results in increased expression of IL6 protein]16818790
D015032ZincZinc promotes the reaction [FCER1A protein results in increased expression of TNF mRNA]16818790
D015032ZincZinc promotes the reaction [FCER1A protein results in increased expression of TNF protein]16818790
D019287Zinc Sulfate"Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]"16818790

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019863IgE binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2964640  
GO:0009986cell surface-IDA1535625  
KEGG ID KEGG Term
hsa04664Fc epsilon RI signaling pathway
hsa05310Asthma
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationTAS
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationIEA
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27421833Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test. (2016)Zuiker RGEur Clin Respir J