Gene: JMJD1C

221037
KDM3C|TRIP-8|TRIP8
jumonji domain containing 1C
protein-coding
10q21.3
Ensembl:ENSG00000171988 MIM:604503 Vega:OTTHUMG00000018311 UniprotKB:Q15652
NG_053187.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.404e-1 (AD)  5.963e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFF40.892
RBM270.891
CCNT10.888
SMCHD10.888
CTDSPL20.885
PBRM10.88
KMT2E0.88
WDFY10.88
ARID4B0.878
TNKS20.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.529
PLA2G5-0.253
HES5-0.228
PTGDR2-0.225
BTBD17-0.212
NANOGNB-0.207
OR4F16-0.202
S100A1-0.198
ARSF-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of JMJD1C mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of JMJD1C mRNA"20453058
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of JMJD1C mRNA"20406850
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to JMJD1C protein modified form]"28751236
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JMJD1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JMJD1C mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of JMJD1C mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of JMJD1C mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of JMJD1C gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of JMJD1C mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of JMJD1C mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of JMJD1C mRNA16483693
D001151ArsenicArsenic affects the methylation of JMJD1C gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of JMJD1C mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of JMJD1C mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JMJD1C mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of JMJD1C mRNA21179406
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to JMJD1C protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of JMJD1C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of JMJD1C gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of JMJD1C mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of JMJD1C mRNA19010381
C018021cobaltous chloridecobaltous chloride results in increased expression of JMJD1C mRNA19376846
D003703DemecolcineDemecolcine results in increased expression of JMJD1C mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of JMJD1C mRNA27392435
D002945CisplatinCisplatin results in decreased expression of JMJD1C mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of JMJD1C mRNA28302478
D004237DiuronDiuron results in decreased expression of JMJD1C mRNA21551480|2515243
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of JMJD1C mRNA28329830
D005485FlutamideFlutamide results in increased expression of JMJD1C mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of JMJD1C mRNA20655997
C001277geldanamycingeldanamycin results in increased expression of JMJD1C mRNA26705709
D005897GlafenineGlafenine results in decreased expression of JMJD1C mRNA24136188
D017313FenretinideFenretinide results in increased expression of JMJD1C mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of JMJD1C mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of JMJD1C mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of JMJD1C mRNA27392435
C410337K 7174K 7174 results in increased expression of JMJD1C mRNA24086573
D007649KetamineKetamine results in decreased expression of JMJD1C mRNA20080153
D007854LeadLead results in decreased expression of JMJD1C mRNA19921347
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of JMJD1C mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of JMJD1C mRNA26378955
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of JMJD1C mRNA27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of JMJD1C mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of JMJD1C mRNA"26251327
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form]28751236
D016685MitomycinJMJD1C protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of JMJD1C mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of JMJD1C mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of JMJD1C mRNA25729387
C016030pantogabpantogab results in increased expression of JMJD1C mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of JMJD1C mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of JMJD1C mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of JMJD1C mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of JMJD1C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of JMJD1C mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of JMJD1C mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of JMJD1C mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of JMJD1C mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of JMJD1C mRNA23370395
D012822Silicon DioxideSilicon Dioxide results in increased expression of JMJD1C mRNA19073995
D012834SilverSilver results in increased expression of JMJD1C mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of JMJD1C mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of JMJD1C mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of JMJD1C mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of JMJD1C mRNA"26680231
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of JMJD1C mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of JMJD1C mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of JMJD1C mRNA25729387
D019772TopotecanTopotecan results in decreased expression of JMJD1C mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of JMJD1C mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of JMJD1C mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of JMJD1C mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of JMJD1C mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of JMJD1C mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of JMJD1C mRNA23179753|2519280
D001335Vehicle EmissionsVehicle Emissions affects the methylation of JMJD1C gene25560391
C025643vinclozolinvinclozolin results in increased expression of JMJD1C mRNA23034163|2355583
D014750VincristineVincristine results in increased expression of JMJD1C mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of JMJD1C mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0005515protein binding-IPI17353003  
GO:0031490chromatin DNA binding-IBA21873635  
GO:0032454histone demethylase activity (H3-K9 specific)-IBA21873635  
GO:0032454histone demethylase activity (H3-K9 specific)-TAS-  
GO:0046872metal ion binding-IEA-  
GO:0046966thyroid hormone receptor binding-TAS7776974  
GO:0051213dioxygenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-TAS7776974  
GO:0007596blood coagulation-TAS-  
GO:0033169histone H3-K9 demethylation-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IBA21873635  
GO:0005622intracellular-NAS7776974  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26414697Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. (2016 Mar 1)Ek WEInt J Cancer