Gene: TDRD6

221400
CT41.2|NY-CO-45|SPATA36|TDR2|bA446F17.4
tudor domain containing 6
protein-coding
6p12.3
Ensembl:ENSG00000180113 MIM:611200 Vega:OTTHUMG00000014788 UniprotKB:O60522
NG_051941.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
9.687e-3 (AD)  8.929e-1 (ND)   (Frontal_Cortex)
6.083e-3 (AD)  3.933e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12528857chr6:46702199 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11961117chr6:46686509 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAALAD20.779
MTRF10.745
RBM480.739
HERC40.739
FSD20.735
PRPF390.719
DNA20.716
PCID20.712
DFFB0.711
AGO30.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU-0.393
MAPKAPK3-0.382
HORMAD2-0.352
AQP5-0.35
HPDL-0.343
DIO2-0.342
ALDH1L1-AS2-0.337
HES5-0.331
HPSE2-0.33
KLRB1-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TDRD6 protein20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TDRD6 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of TDRD6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TDRD6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TDRD6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TDRD6 gene28505145
D016572CyclosporineCyclosporine results in decreased expression of TDRD6 mRNA20106945
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TDRD6 mRNA26011545
D009532NickelNickel results in decreased expression of TDRD6 mRNA24768652|2558310
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TDRD6 mRNA"25510870
D011374ProgesteroneProgesterone results in increased expression of TDRD6 mRNA19690047
D013849ThimerosalThimerosal results in increased expression of TDRD6 mRNA27188386
D014212TretinoinTretinoin results in increased expression of TDRD6 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of TDRD6 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TDRD6 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD6 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TDRD6 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of TDRD6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TDRD6 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TDRD6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0033391chromatoid body-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNAIEA
R-HSA-5601884PIWI-interacting RNA (piRNA) biogenesisIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation