Gene info: ID 221496

Gene: LEMD2

GENE ID: 221496

Synonyms: CTRCT42|NET25|dJ482C21.1

Description: LEM domain containing 2

Gene type: protein-coding

Location: 6p21.31

dbXrefs: Ensembl:ENSG00000161904 MIM:616312 Vega:OTTHUMG00000014535 UniprotKB:Q8NC56

RefSeq: NG_053042.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : 6.706e-1 (AD) 7.948e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.988e-1 (AD) 1.055e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2296744	chr6:33772605 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM259	0.922
CCDC130	0.914
SNRNP70	0.908
LMF2	0.903
DUS1L	0.897
CLASRP	0.896
RING1	0.896
AKAP8L	0.894
XAB2	0.892
LRCH4	0.892

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.691
OR4F29	-0.673
MTRNR2L9	-0.288
MTRNR2L6	-0.265
OR4F16	-0.252
UNC45B	-0.236
MTRNR2L10	-0.235
TTLL10-AS1	-0.224
MYL1	-0.214
LMOD2	-0.211

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of LEMD2 mRNA"	19162173
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of LEMD2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEMD2 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of LEMD2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of LEMD2 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LEMD2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of LEMD2 mRNA	21839799
C006780	bisphenol A	bisphenol A results in decreased expression of LEMD2 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LEMD2 mRNA	28628672
C584509	C646 compound	C646 compound results in increased expression of LEMD2 mRNA	26191083
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of LEMD2 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEMD2 mRNA]	17585979
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA	24690739
D016572	Cyclosporine	Cyclosporine results in increased expression of LEMD2 mRNA	20106945
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LEMD2 mRNA	28628672
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA	24690739
D005485	Flutamide	Flutamide results in decreased expression of LEMD2 mRNA	24793618
C069837	fullerene C60	fullerene C60 results in increased expression of LEMD2 mRNA	19167457
C492448	ICG 001	ICG 001 results in increased expression of LEMD2 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LEMD2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of LEMD2 mRNA	28628672
D008942	Mitoxantrone	LEMD2 mRNA affects the susceptibility to Mitoxantrone	16044152
C028007	nickel monoxide	nickel monoxide results in increased expression of LEMD2 mRNA	19167457
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of LEMD2 mRNA	21061450
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of LEMD2 protein	23718831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LEMD2 mRNA	21570461
D014520	Urethane	Urethane results in increased expression of LEMD2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased methylation of LEMD2 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of LEMD2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	28242692

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006998	nuclear envelope organization	-	IBA	21873635
GO:0006998	nuclear envelope organization	-	IMP	17097643
GO:0022008	neurogenesis	-	IEA	-
GO:0030514	negative regulation of BMP signaling pathway	-	IBA	21873635
GO:0035914	skeletal muscle cell differentiation	-	IGI	19720741
GO:0043409	negative regulation of MAPK cascade	-	IEA	-
GO:0051898	negative regulation of protein kinase B signaling	-	IEA	-
GO:0060914	heart formation	-	IEA	-
GO:0071168	protein localization to chromatin	-	IMP	28242692

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000785	chromatin	colocalizes_with	IDA	28242692
GO:0005635	nuclear envelope	colocalizes_with	IDA	28242692
GO:0005637	nuclear inner membrane	-	TAS	28242692
GO:0005639	integral component of nuclear inner membrane	-	IBA	21873635
GO:0005639	integral component of nuclear inner membrane	-	IDA	16339967
GO:0005783	endoplasmic reticulum	colocalizes_with	IDA	28242692
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	TAS	28242692
GO:0031965	nuclear membrane	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1640170	Cell Cycle	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2980766	Nuclear Envelope Breakdown	TAS
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	TAS
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	TAS
R-HSA-2995410	Nuclear Envelope Reassembly	TAS
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	TAS
R-HSA-68875	Mitotic Prophase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal