Gene: PHACTR1

221692
RPEL|RPEL1|dJ257A7.2
phosphatase and actin regulator 1
protein-coding
6p24.1
Ensembl:ENSG00000112137 MIM:608723 Vega:OTTHUMG00000014270 UniprotKB:Q9C0D0
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.423e-1 (AD)  2.334e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL180.926
LHFPL40.926
SCN8A0.924
MMP240.917
FAM78B0.916
SHC30.914
TMEM178B0.911
PCDHGC50.909
PCDHAC20.907
RGS7BP0.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.572
MYL3-0.571
RAB13-0.563
COPZ2-0.559
SNHG18-0.549
CSAG1-0.543
FLT3LG-0.523
HEY2-0.516
HEBP2-0.516
AGTRAP-0.512

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PHACTR1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PHACTR1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PHACTR1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PHACTR1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PHACTR1 gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PHACTR1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHACTR1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of PHACTR1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of PHACTR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PHACTR1 gene28505145
D002104CadmiumCadmium results in decreased expression of PHACTR1 mRNA24067728
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PHACTR1 mRNA24374135
D003024ClozapineClozapine results in increased expression of PHACTR1 mRNA14647396
D016572CyclosporineCyclosporine results in increased expression of PHACTR1 mRNA20106945
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of PHACTR1 promoter27415467
D019833GenisteinGenistein results in decreased methylation of PHACTR1 gene28505145
D019833GenisteinGenistein results in increased methylation of PHACTR1 gene28505145
D006220HaloperidolHaloperidol results in increased expression of PHACTR1 mRNA14647396
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PHACTR1 mRNA24796395
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to PHACTR1 promoter]20348232
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PHACTR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHACTR1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of PHACTR1 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PHACTR1 mRNA27935865
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of PHACTR1 mRNA23602845
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PHACTR1 mRNA27935865
D011441PropylthiouracilPropylthiouracil results in increased expression of PHACTR1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PHACTR1 mRNA23806026
C009495titanium dioxidetitanium dioxide results in decreased expression of PHACTR1 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PHACTR1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PHACTR1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of PHACTR1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PHACTR1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PHACTR1 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of PHACTR1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-ISS-  
GO:0004864protein phosphatase inhibitor activity-IEA-  
GO:0008157protein phosphatase 1 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031032actomyosin structure organization-IMP22976292  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO:0043149stress fiber assembly-IMP22976292  
GO:0048870cell motility-IMP22976292  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005829cytosol-ISS-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22513829A genetic risk variant for myocardial infarction on chromosome 6p24 is associated with impaired central hemodynamic indexes. (2012 Jul)Patel RSAm J Hypertens
25469260Association of a transcription factor 21 gene polymorphism with hypertension. (2015 Jan)Fujimaki TBiomed Rep