Gene: SYCP2L

221711
C6orf177|NO145|dJ62D2.1
synaptonemal complex protein 2 like
protein-coding
6p24.2
Ensembl:ENSG00000153157 MIM:616799 Vega:OTTHUMG00000014250 UniprotKB:Q5T4T6
NC_000006.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.331e-1 (AD)  8.041e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4713039chr6:10906023 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNI3K0.733
ABCA100.727
OVGP10.724
DNAH10.717
AMY2B0.713
NR2C10.701
SEC31B0.694
ZNF2510.693
WDR190.692
MFN10.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.364
PDZK1IP1-0.363
TMEM51-0.334
LYPD1-0.318
EVC2-0.313
MTRNR2L8-0.305
G0S2-0.304
FOXJ1-0.297
MDFI-0.285
PGF-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000393Air PollutantsAir Pollutants analog results in decreased expression of SYCP2L mRNA21757418
C006780bisphenol Abisphenol A results in decreased expression of SYCP2L mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SYCP2L mRNA26079696
D002945CisplatinCisplatin results in decreased expression of SYCP2L mRNA27594783
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SYCP2L mRNA27432991
D011374ProgesteroneProgesterone results in increased expression of SYCP2L mRNA19690047
C012589trichostatin Atrichostatin A results in increased expression of SYCP2L mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SYCP2L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SYCP2L mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SYCP2L mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0000780condensed nuclear chromosome, centromeric region-IDA26362258  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer