Gene: SDK1

221935
-
sidekick cell adhesion molecule 1
protein-coding
7p22.2
Ensembl:ENSG00000146555 MIM:607216 Vega:OTTHUMG00000151733 UniprotKB:Q7Z5N4
NG_051298.1
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.916e-1 (AD)  9.102e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17134615chr7:4209049 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs7797803chr7:4181432 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs619672chr7:4156356 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs11978979chr7:3986377 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10235080chr7:3379870 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05642264chr7:4169314SDK19.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH80.816
CUX20.813
PIP5K1B0.812
FAM163A0.808
SSTR40.797
PRDM110.795
IGSF30.791
CDH220.791
KCNK30.791
KCNN20.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.516
FAM107B-0.506
ZFP57-0.5
LPAR1-0.495
TGFB3-0.493
OTUD7B-0.489
MYOT-0.486
BCAS1-0.483
SGMS2-0.472
SLCO1A2-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SDK1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SDK1 mRNA22100608
D001151ArsenicArsenic affects the methylation of SDK1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SDK1 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SDK1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SDK1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of SDK1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of SDK1 mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SDK1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SDK1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of SDK1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of SDK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SDK1 mRNA21592394
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SDK1 mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SDK1 mRNA"25554681
D009532NickelNickel results in increased expression of SDK1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of SDK1 mRNA19167457
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
D010936Plant ExtractsPlant Extracts results in decreased expression of SDK1 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of SDK1 mRNA19690047
D013629TamoxifenTamoxifen results in increased expression of SDK1 mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SDK1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SDK1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SDK1 mRNA20106945
D014212TretinoinTretinoin results in decreased expression of SDK1 mRNA23724009
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SDK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SDK1 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SDK1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-ISS-  
GO:0007416synapse assembly-ISS-  
GO:0010842retina layer formation-ISS-  
GO:0045216cell-cell junction organization-TAS-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0060998regulation of dendritic spine development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-373756SDK interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal