Gene info: ID 221935

Gene: SDK1

GENE ID: 221935

Synonyms: -

Description: sidekick cell adhesion molecule 1

Gene type: protein-coding

Location: 7p22.2

dbXrefs: Ensembl:ENSG00000146555 MIM:607216 Vega:OTTHUMG00000151733 UniprotKB:Q7Z5N4

RefSeq: NG_051298.1

Retrived from: SNP Mapped

SNPs: 5 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.916e-1 (AD) 9.102e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17134615	chr7:4209049 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs7797803	chr7:4181432 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs619672	chr7:4156356 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs11978979	chr7:3986377 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10235080	chr7:3379870 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05642264	chr7:4169314	SDK1		9.500e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PCDH8	0.816
CUX2	0.813
PIP5K1B	0.812
FAM163A	0.808
SSTR4	0.797
PRDM11	0.795
IGSF3	0.791
CDH22	0.791
KCNK3	0.791
KCNN2	0.79

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CTNNA3	-0.516
FAM107B	-0.506
ZFP57	-0.5
LPAR1	-0.495
TGFB3	-0.493
OTUD7B	-0.489
MYOT	-0.486
BCAS1	-0.483
SGMS2	-0.472
SLCO1A2	-0.462

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SDK1 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SDK1 mRNA	22100608
D001151	Arsenic	Arsenic affects the methylation of SDK1 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SDK1 mRNA	21871943
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of SDK1 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SDK1 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of SDK1 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of SDK1 mRNA	25181051
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SDK1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SDK1 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in decreased expression of SDK1 mRNA	25016146
D002117	Calcitriol	Calcitriol results in increased expression of SDK1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of SDK1 mRNA	21592394
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SDK1 mRNA	27392435
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SDK1 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of SDK1 mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of SDK1 mRNA	19167457
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
D010936	Plant Extracts	Plant Extracts results in decreased expression of SDK1 mRNA	23557933
D011374	Progesterone	Progesterone results in decreased expression of SDK1 mRNA	19690047
D013629	Tamoxifen	Tamoxifen results in increased expression of SDK1 mRNA	25123088
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of SDK1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of SDK1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SDK1 mRNA	20106945
D014212	Tretinoin	Tretinoin results in decreased expression of SDK1 mRNA	23724009
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDK1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SDK1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SDK1 mRNA	19101580\|2317975
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SDK1 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0042802	identical protein binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	ISS	-
GO:0007416	synapse assembly	-	ISS	-
GO:0010842	retina layer formation	-	ISS	-
GO:0045216	cell-cell junction organization	-	TAS	-
GO:0048148	behavioral response to cocaine	-	IEA	-
GO:0060998	regulation of dendritic spine development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0045202	synapse	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-373756	SDK interactions	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-446728	Cell junction organization	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal