Gene: DAGLB

221955
DAGLBETA|KCCR13L
diacylglycerol lipase beta
protein-coding
7p22.1
Ensembl:ENSG00000164535 MIM:614016 Vega:OTTHUMG00000125513 UniprotKB:Q8NCG7
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.427e-2 (AD)  7.315e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PISD0.934
EDC40.933
MKL10.926
ZFYVE270.924
URGCP0.922
AP2A20.918
EFTUD20.918
SIN3B0.913
ATP6AP10.911
BAIAP20.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.545
OR4F29-0.503
ASB4-0.413
RAI14-0.38
MBNL3-0.375
YES1-0.363
HEY2-0.358
FZD10-0.357
LRAT-0.355
MYOM1-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane results in decreased activity of DAGLB protein"18657971
C0758091-stearoyl-2-arachidonoylglycerolDAGLB protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol18657971
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DAGLB mRNA"20702594
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DAGLB mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of DAGLB mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DAGLB mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DAGLB mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DAGLB mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAGLB mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of DAGLB mRNA21179406
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAGLB mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of DAGLB mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of DAGLB mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DAGLB mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAGLB mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DAGLB mRNA27392435
D004041Dietary FatsDietary Fats affects the expression of DAGLB mRNA19680557
C024565ethylene dichlorideethylene dichloride results in decreased expression of DAGLB mRNA28189721
D018120FinasterideFinasteride results in increased expression of DAGLB mRNA24136188
C094503glyceryl 2-arachidonateDAGLB protein results in increased chemical synthesis of glyceryl 2-arachidonate18657971
D017313FenretinideFenretinide results in decreased expression of DAGLB mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAGLB mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAGLB mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of DAGLB mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAGLB mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DAGLB mRNA27392435
D007649KetamineKetamine results in decreased expression of DAGLB mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DAGLB mRNA25613284
C104810methyl arachidonylfluorophosphonatemethyl arachidonylfluorophosphonate results in decreased activity of DAGLB protein18657971
C055122orlistatorlistat results in decreased activity of DAGLB protein18657971
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DAGLB mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DAGLB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DAGLB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DAGLB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DAGLB mRNA]17655762
D000073878Palm OilPalm Oil affects the expression of DAGLB mRNA19680557
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DAGLB mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of DAGLB mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DAGLB mRNA]17655762
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DAGLB mRNA18593933
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DAGLB mRNA19073995
D018038Sodium SeleniteSodium Selenite results in increased expression of DAGLB mRNA18175754
C013698tallowtallow affects the expression of DAGLB mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DAGLB mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DAGLB mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of DAGLB mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DAGLB mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DAGLB mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of DAGLB mRNA28973697
D014520UrethaneUrethane results in increased expression of DAGLB mRNA28818685
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DAGLB mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of DAGLB mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DAGLB mRNA]17655762
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DAGLB mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0047372acylglycerol lipase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007405neuroblast proliferation-IEA-  
GO:0016042lipid catabolic process-IEA-  
GO:0019369arachidonic acid metabolic process-IBA21873635  
GO:0019369arachidonic acid metabolic process-IDA14610053  
GO:0022008neurogenesis-IBA21873635  
GO:0042136neurotransmitter biosynthetic process-IBA21873635  
GO:0042136neurotransmitter biosynthetic process-IEA-  
GO:0046340diacylglycerol catabolic process-IBA21873635  
GO:0071926endocannabinoid signaling pathway-IBA21873635  
GO:0098921retrograde trans-synaptic signaling by endocannabinoid-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IDA14610053  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0045211postsynaptic membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-426048Arachidonate production from DAGTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22879519The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis. (2013 Oct)Tyler ADGut