Gene: THSD7A

221981
-
thrombospondin type 1 domain containing 7A
protein-coding
7p21.3
Ensembl:ENSG00000005108 MIM:612249 Vega:OTTHUMG00000152346 UniprotKB:Q9UPZ6
NG_027670.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.594e-1 (AD)  9.448e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2526100chr7:11638151 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPR30.744
NDNF0.737
IGF10.702
DAB10.699
NR2F20.693
PDGFD0.692
ADAMTS50.683
ITGA40.68
PKP20.679
GRPR0.67

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAIR2-0.397
FAM178B-0.395
FEZF2-0.388
SH2D1B-0.385
ANKRD23-0.379
NKX6-2-0.377
NRN1L-0.375
C7orf61-0.374
KIF19-0.369
NPFFR2-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of THSD7A mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of THSD7A mRNA22100608|2715375
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of THSD7A mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of THSD7A gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA27858113
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of THSD7A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of THSD7A mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of THSD7A mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of THSD7A mRNA26272509
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA27858113
C031180chrysenechrysene results in decreased expression of THSD7A mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of THSD7A mRNA19376846
C030973cupric oxidecupric oxide results in decreased expression of THSD7A mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of THSD7A mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of THSD7A mRNA20106945
C014347decitabinedecitabine results in decreased methylation of THSD7A gene27923600
C118739entinostatentinostat results in decreased expression of THSD7A mRNA27188386
C118739entinostatentinostat results in increased expression of THSD7A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
D005485FlutamideFlutamide results in decreased expression of THSD7A mRNA24136188
D017313FenretinideFenretinide results in decreased expression of THSD7A mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THSD7A mRNA24435446
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THSD7A mRNA26644586
C042720mercuric bromidemercuric bromide results in increased expression of THSD7A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of THSD7A mRNA28001369
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of THSD7A mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THSD7A mRNA19710929
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of THSD7A mRNA17404688|2086464
D011441PropylthiouracilPropylthiouracil affects the expression of THSD7A mRNA24780913
D012643SeleniumSelenium results in decreased expression of THSD7A mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of THSD7A mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of THSD7A mRNA25895662
D012834SilverSilver results in decreased expression of THSD7A mRNA27131904
D013792ThalidomideThalidomide results in increased expression of THSD7A mRNA28892372
D014212TretinoinTretinoin results in decreased expression of THSD7A mRNA23724009
D014212TretinoinTretinoin results in increased expression of THSD7A mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of THSD7A mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of THSD7A mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of THSD7A mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of THSD7A mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of THSD7A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of THSD7A mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of THSD7A mRNA19101580|2438349
C025643vinclozolinvinclozolin affects the expression of THSD7A mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of THSD7A mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA27214550  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal