Gene: ALDH3B2

222
ALDH8
aldehyde dehydrogenase 3 family member B2
protein-coding
11q13.2
Ensembl:ENSG00000132746 MIM:601917 Vega:OTTHUMG00000167284 UniprotKB:P48448
NG_012255.2
PubMed
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.802e-1 (AD)  8.113e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DSC30.742
LAD10.741
NCCRP10.731
KRT160.707
SERPINB50.69
TACSTD20.688
SPINK50.676
KRT140.672
KLK110.672
IVL0.669

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSPN-0.317
HIST3H2A-0.301
ZNF574-0.296
SCLY-0.277
CCDC13-0.274
C16orf46-0.269
ZNF835-0.268
CDT1-0.256
UPP2-0.255
RHEBL1-0.254

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB09116Calcium carbimideSmall Molecule156-62-7Approved|WithdrawnTarget
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of ALDH3B2 mRNA"20638727
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
D001151ArsenicArsenic affects the methylation of ALDH3B2 gene25304211
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ALDH3B2 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of ALDH3B2 mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ALDH3B2 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH3B2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ALDH3B2 mRNA28472532
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ALDH3B2 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of ALDH3B2 mRNA19167446
D002117CalcitriolCalcitriol results in increased expression of ALDH3B2 mRNA26485663
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH3B2 mRNA20938992
C071834glycidamideglycidamide results in decreased expression of ALDH3B2 mRNA17822822
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ALDH3B2 mRNA26846883
C042720mercuric bromidemercuric bromide results in increased expression of ALDH3B2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ALDH3B2 mRNA20938992
D015735MifepristoneMifepristone results in decreased expression of ALDH3B2 mRNA17584828
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ALDH3B2 mRNA20660070
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ALDH3B2 mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of ALDH3B2 mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ALDH3B2 mRNA25351596
C009495titanium dioxidetitanium dioxide affects the expression of ALDH3B2 mRNA23557971
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of ALDH3B2 mRNA24096154
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH3B2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ALDH3B2 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of ALDH3B2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00040283-chloroallyl aldehyde dehydrogenase activity-IBA21873635  
GO:00040283-chloroallyl aldehyde dehydrogenase activity-TAS8890755  
GO:0004030aldehyde dehydrogenase [NAD(P)+] activity-EXP25286108  
GO ID GO Term Qualifier Evidence PubMed
GO:0006066alcohol metabolic process-TAS8890755  
GO:0006068ethanol catabolic process-IEA-  
GO:0006629lipid metabolic process-TAS8890755  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005811lipid droplet-TAS-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00340Histidine metabolism
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23387924Genome-wide DNA methylation analysis in alcohol dependence. (2013 Mar)Zhang RAddict Biol
29299137Association of ALDH3B2 gene polymorphism and risk factors with susceptibility of esophageal squamous cell carcinoma in a Chinese population: a case-control study involving 2,358 subjects. (2017 Dec 15)Yin JOncotarget