Gene: FCN2

2220
EBP-37|FCNL|P35|ficolin-2
ficolin 2
protein-coding
9q34.3
Ensembl:ENSG00000160339 MIM:601624 Vega:OTTHUMG00000020892 UniprotKB:Q15485
NG_011649.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.739e-1 (AD)  8.386e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01748082chr9:137772580FCN22.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COLCA20.636
PAPLN0.626
ERBB20.616
PIK3IP10.6
TTLL60.599
NEK80.593
CPT20.591
ALDH1L10.591
WLS0.588
EHHADH0.585

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.34
VIT-0.31
KLRG1-0.307
FAM19A4-0.303
CRH-0.297
FIBCD1-0.292
VGF-0.287
LAMB3-0.287
FLRT1-0.286
SMIM18-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FCN2 mRNA"23146750
D000082AcetaminophenAcetaminophen results in decreased expression of FCN2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FCN2 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of FCN2 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FCN2 mRNA22316170
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FCN2 mRNA26472689
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of FCN2 protein28596144
D003976DiazinonDiazinon results in increased methylation of FCN2 gene22964155
D008727MethotrexateMethotrexate results in increased expression of FCN2 mRNA24449571
D014635Valproic AcidValproic Acid results in increased methylation of FCN2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003823antigen binding-IDA8576206  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI19632990  21054788  21490156  
GO:0043394proteoglycan binding-IDA8576206  
GO:0046872metal ion binding-IEA-  
GO:0048306calcium-dependent protein binding-IPI12421953  
GO:2001065mannan binding-IDA8576206  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IDA14707097  15804047  
GO:0001867complement activation, lectin pathway-TAS-  
GO:0006508proteolysis-IEA-  
GO:0006956complement activation-TAS-  
GO:0008228opsonization-IDA8576206  
GO:0043654recognition of apoptotic cell-IDA15804047  
GO:0050829defense response to Gram-negative bacterium-IDA8576206  
GO:0050830defense response to Gram-positive bacterium-IDA14707097  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166662Lectin pathway of complement activationTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-166786Creation of C4 and C2 activatorsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2855086Ficolins bind to repetitive carbohydrate structures on the target cell surfaceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490795Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF. (2016)Ashley SLPLoS One