Gene: NAPEPLD

222236
C7orf18|FMP30|NAPE-PLD
N-acyl phosphatidylethanolamine phospholipase D
protein-coding
7q22.1
Ensembl:ENSG00000161048 MIM:612334 Vega:OTTHUMG00000157204 UniprotKB:Q6IQ20
NC_000007.14
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.803e-1 (AD)  7.397e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS410.95
RASA10.946
MTMR40.943
CLCN40.939
COL4A3BP0.939
ADAM220.938
FAM217B0.937
WDR470.936
PIK3CB0.935
DNAJC180.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.493
OR4F29-0.462
TFPI2-0.454
RAB13-0.448
CSAG1-0.448
MDFI-0.438
PRRX2-0.426
RNF135-0.424
AQP5-0.423
S100A16-0.412

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NAPEPLD mRNA28329830
D000082AcetaminophenAcetaminophen results in decreased expression of NAPEPLD mRNA21420995
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NAPEPLD mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NAPEPLD mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NAPEPLD mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAPEPLD mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NAPEPLD mRNA26496021
C006780bisphenol Abisphenol A affects the expression of NAPEPLD mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NAPEPLD mRNA27014939
C006780bisphenol Abisphenol A results in decreased expression of NAPEPLD mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of NAPEPLD mRNA27641926
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NAPEPLD mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NAPEPLD mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NAPEPLD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NAPEPLD promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of NAPEPLD mRNA24752500
D003471CuprizoneCuprizone results in decreased expression of NAPEPLD mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NAPEPLD mRNA20106945|2556210
D013759DronabinolDronabinol results in decreased expression of NAPEPLD mRNA16597638
D004008DiclofenacDiclofenac affects the expression of NAPEPLD mRNA24752500
D004026DieldrinDieldrin results in increased expression of NAPEPLD mRNA28385952
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NAPEPLD mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NAPEPLD mRNA28329830
D006046GoldGold results in decreased expression of NAPEPLD mRNA25523186
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NAPEPLD protein18951874
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NAPEPLD mRNA28001369
C500085muraglitazarmuraglitazar results in increased expression of NAPEPLD mRNA21515302
D009532NickelNickel results in decreased expression of NAPEPLD mRNA23195993
C055122orlistatorlistat results in decreased activity of NAPEPLD protein16466961
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of NAPEPLD mRNA23602845
D010578PetroleumPetroleum affects the expression of NAPEPLD mRNA25208076
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of NAPEPLD mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of NAPEPLD mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NAPEPLD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NAPEPLD mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAPEPLD mRNA24780913
D011794QuercetinQuercetin results in decreased expression of NAPEPLD mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of NAPEPLD mRNA21515302
C501413tesaglitazartesaglitazar results in increased expression of NAPEPLD mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of NAPEPLD mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAPEPLD mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NAPEPLD protein18951874
C009495titanium dioxidetitanium dioxide results in increased expression of NAPEPLD mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NAPEPLD mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of NAPEPLD mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of NAPEPLD mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NAPEPLD mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NAPEPLD mRNA29024780
C057693troglitazonetroglitazone results in increased expression of NAPEPLD mRNA28973697
C057693troglitazonetroglitazone results in increased expression of NAPEPLD mRNA21515302
D014520UrethaneUrethane results in decreased expression of NAPEPLD mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of NAPEPLD mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NAPEPLD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NAPEPLD mRNA24935251|2915479
D014638VanadatesVanadates results in increased expression of NAPEPLD mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NAPEPLD gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of NAPEPLD mRNA"25208076
C088658zoledronic acidzoledronic acid results in increased expression of NAPEPLD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IDA25684574  
GO:0016787hydrolase activity-IBA21873635  
GO:0042802identical protein binding-IPI25684574  
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity-IBA21873635  
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity-IDA25684574  
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity-TAS-  
GO:0102200N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0001659temperature homeostasis-ISS-  
GO:0007568aging-IEA-  
GO:0009395phospholipid catabolic process-IEA-  
GO:0035900response to isolation stress-IEA-  
GO:0050729positive regulation of inflammatory response-ISS-  
GO:0070291N-acylethanolamine metabolic process-IBA21873635  
GO:0070291N-acylethanolamine metabolic process-IEA-  
GO:0070292N-acylphosphatidylethanolamine metabolic process-IBA21873635  
GO:0070292N-acylphosphatidylethanolamine metabolic process-IDA25684574  
GO:0090336positive regulation of brown fat cell differentiation-ISS-  
GO:1903999negative regulation of eating behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-ISS-  
GO:0005654nucleoplasm-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-ISS-  
GO:0005794Golgi apparatus-IDA25684574  
GO:0005829cytosol-IDA-  
GO:0042622photoreceptor outer segment membrane-TAS-  
GO:0043227membrane-bounded organelle-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2453864Retinoid cycle disease eventsTAS
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)TAS
R-HSA-2466712Biosynthesis of A2E, implicated in retinal degradationTAS
R-HSA-2474795Diseases associated with visual transductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28554848Sex- and hormone-dependent alterations in alcohol withdrawal-induced anxiety and corticolimbic endocannabinoid signaling. (2017 Sep 15)Henricks AMNeuropharmacology
27578612Sex differences in alcohol consumption and alterations in nucleus accumbens endocannabinoid mRNA in alcohol-dependent rats. (2016 Oct 29)Henricks AMNeuroscience