Gene: CDHR3

222256
CDH28
cadherin related family member 3
protein-coding
7q22.3
Ensembl:ENSG00000128536 MIM:615610 Vega:OTTHUMG00000157520 UniprotKB:Q6ZTQ4
NC_000007.14
SNP Mapped
1   ANCO-SNPs
ND
0   
5.400e-1 (AD)  6.820e-1 (ND)   (Frontal_Cortex)
9.743e-1 (AD)  9.818e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17152264chr7:105907952 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UNKL0.741
QSOX20.736
SPEG0.735
URGCP0.731
NRF10.73
ARHGEF170.729
LPIN10.729
ZMYM30.727
GGA20.725
FBXO420.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.389
OR4F5-0.376
TBX21-0.363
CD2-0.36
CD3G-0.357
TFPI2-0.353
GZMK-0.352
CTNNA3-0.348
GZMA-0.347
LCK-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CDHR3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDHR3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CDHR3 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDHR3 mRNA22228805
D004041Dietary FatsDietary Fats results in increased expression of CDHR3 mRNA25016146
D017313FenretinideFenretinide results in increased expression of CDHR3 mRNA28973697
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDHR3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDHR3 mRNA"25554681
D053260SootSoot results in decreased expression of CDHR3 mRNA26551751
D014520UrethaneUrethane results in decreased expression of CDHR3 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA24241537  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal