Gene: FDPS

2224
FPPS|FPS|POROK9
farnesyl diphosphate synthase
protein-coding
1q22
Ensembl:ENSG00000160752 MIM:134629 Vega:OTTHUMG00000013909 UniprotKB:P14324
NG_045218.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.542e-1 (AD)  6.179e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAT20.93
ACLY0.915
DCTN20.912
GMPR20.909
PSMC10.902
PSMD70.901
VCP0.897
PRPS10.895
ACTR100.895
ALAS10.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.588
MTRNR2L6-0.4
MTRNR2L9-0.377
MTRNR2L10-0.362
P2RY14-0.327
MTRNR2L8-0.32
MTRNR2L2-0.313
TTLL10-0.303
S100A12-0.294

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00282PamidronateSmall Molecule40391-99-9ApprovedTarget
DB00399Zoledronic acidSmall Molecule118072-93-8ApprovedTarget
DB00630Alendronic acidSmall Molecule66376-36-1ApprovedTarget
DB00710IbandronateSmall Molecule114084-78-5Approved|InvestigationalTarget
DB00884RisedronateSmall Molecule105462-24-6Approved|InvestigationalTarget
DB01785Dimethylallyl DiphosphateSmall Molecule358-72-5ExperimentalTarget
DB02508Isopentyl PyrophosphateSmall MoleculeExperimentalTarget
DB02552Geranyl DiphosphateSmall MoleculeExperimentalTarget
DB04714ISOPENTENYL PYROPHOSPHATESmall MoleculeExperimentalTarget
DB06548Minodronic acidSmall Molecule180064-38-4InvestigationalTarget
DB07780FARNESYL DIPHOSPHATESmall MoleculeExperimentalTarget
DB07841Geranylgeranyl diphosphateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FDPS mRNA"15302862
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FDPS mRNA"19162173
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDPS mRNA26821219
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FDPS mRNA"22698814
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of FDPS mRNA26821219
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FDPS mRNA28329830
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of FDPS mRNA26821219
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDPS mRNA"28433925
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of FDPS mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FDPS mRNA"21346803
C5185762-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate"2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of FDPS mRNA"17327690
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of FDPS protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FDPS mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of FDPS mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of FDPS mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of FDPS mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FDPS mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FDPS mRNA]17585979
C096064acteinactein results in increased expression of FDPS mRNA19527300
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FDPS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FDPS mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FDPS mRNA19770486
C430898AGN 194204AGN 194204 results in increased expression of FDPS mRNA15302862
C000188alachloralachlor results in increased expression of FDPS mRNA12419858
D019386AlendronateAlendronate results in decreased activity of FDPS protein11160603
D019386AlendronateAlendronate results in decreased activity of FDPS protein26073627
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of FDPS protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of FDPS protein26072098
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of FDPS mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of FDPS mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FDPS mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of FDPS mRNA"22863853
D000965AntimonyAntimony results in decreased expression of FDPS mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of FDPS mRNA17547211
C519728archazolid Barchazolid B results in increased expression of FDPS mRNA25218289
C006632arsenic trioxidearsenic trioxide results in decreased expression of FDPS mRNA27829220
C406592azaspiracidazaspiracid results in increased expression of FDPS mRNA28939011
D001507BeclomethasoneBeclomethasone results in increased expression of FDPS mRNA23656298
D001553BenzbromaroneBenzbromarone affects the expression of FDPS mRNA19483382
D001554BenzeneBenzene affects the expression of FDPS mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FDPS mRNA21632981|2217879
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FDPS mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FDPS mRNA19770486|2071347
D004958EstradiolEstradiol results in decreased expression of FDPS mRNA19484750
C006780bisphenol Abisphenol A affects the expression of FDPS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FDPS mRNA25270620
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDPS mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of FDPS mRNA24768697|2518105
C032036bromobenzenebromobenzene results in decreased expression of FDPS mRNA15056800
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FDPS mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FDPS mRNA24527689
D002211CapsaicinCapsaicin results in increased expression of FDPS mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FDPS mRNA16239168
D004390ChlorpyrifosChlorpyrifos results in increased expression of FDPS mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of FDPS mRNA21356183
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FDPS mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of FDPS mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FDPS mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of FDPS mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FDPS mRNA]17585979
D002994ClofibrateClofibrate affects the expression of FDPS mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of FDPS mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FDPS mRNA17602206
D003024ClozapineClozapine results in increased expression of FDPS mRNA17052361
C018021cobaltous chloridecobaltous chloride results in decreased expression of FDPS mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of FDPS mRNA21139344
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of FDPS mRNA21356183
D003300CopperCopper results in increased expression of FDPS mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FDPS mRNA20971185
D003300CopperCopper results in decreased expression of FDPS mRNA17205981
D003300CopperCopper results in decreased expression of FDPS protein23882024
D019327Copper SulfateCopper Sulfate results in decreased expression of FDPS mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FDPS mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FDPS mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of FDPS mRNA19174923
C030973cupric oxidecupric oxide analog results in decreased expression of FDPS protein23882024
D003474CurcuminCurcumin results in increased expression of FDPS mRNA16713233
D003474CurcuminCurcumin affects the expression of FDPS mRNA27208389
D003474CurcuminCurcumin results in decreased expression of FDPS mRNA27208389
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of FDPS mRNA20106945|2556210
C093628cyproconazolecyproconazole affects the expression of FDPS mRNA22045034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FDPS mRNA]27941970
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FDPS mRNA16054899
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FDPS mRNA17379624|2126653
D002945CisplatinCisplatin results in increased expression of FDPS mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FDPS mRNA26924002
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of FDPS mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of FDPS mRNA15238619|2260994
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of FDPS mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of FDPS mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of FDPS mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDPS mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FDPS mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FDPS mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FDPS mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FDPS mRNA15171707
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FDPS mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of FDPS mRNA17547211
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of FDPS mRNA28939011
D004147DioxinsDioxins affects the expression of FDPS mRNA20463971
D004164DiphosphonatesDiphosphonates results in decreased activity of FDPS protein19505369
D004237DiuronDiuron results in decreased expression of FDPS mRNA21551480
D000431EthanolEthanol results in increased expression of FDPS mRNA19167417
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of FDPS mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FDPS mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FDPS mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FDPS mRNA15576828
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FDPS mRNA23550701
D005001EthionineEthionine affects the expression of FDPS mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of FDPS mRNA28189721
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of FDPS mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FDPS mRNA23649840
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of FDPS mRNA"23333450
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of FDPS mRNA17347304
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FDPS mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of FDPS mRNA28329830
C061365flusilazoleflusilazole affects the expression of FDPS mRNA22634333
D005485FlutamideFlutamide results in increased expression of FDPS mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of FDPS mRNA23649840
C056933fumonisin B1fumonisin B1 results in decreased expression of FDPS mRNA16221962
D005897GlafenineGlafenine results in increased expression of FDPS mRNA24136188
C409722hexaconazolehexaconazole affects the expression of FDPS mRNA22045034
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of FDPS mRNA17183730
D006861Hydrogen Peroxide[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA18032389
C073007ibandronic acidibandronic acid results in decreased activity of FDPS protein11160603|1832572
C073007ibandronic acidibandronic acid results in decreased activity of FDPS protein18325729
C073007ibandronic acidibandronic acid results in increased expression of FDPS mRNA18325729
C492448ICG 001ICG 001 results in increased expression of FDPS mRNA26191083
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FDPS mRNA16054899
C004809isopentenyl pyrophosphate[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate19699819
C016527isoquercitrin[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA18032389
C544151jinfukangjinfukang results in increased expression of FDPS mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of FDPS mRNA15618438
C017461lead nitratelead nitrate results in increased expression of FDPS mRNA15475176
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of FDPS mRNA20713471
D008752Methylene ChlorideMethylene Chloride affects the expression of FDPS mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FDPS mRNA23649840
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of FDPS mRNA22401849
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of FDPS mRNA22087261
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FDPS mRNA24625837
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FDPS mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FDPS protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FDPS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FDPS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FDPS mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FDPS mRNA27344345
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of FDPS mRNA26821219
C022838nickel chloridenickel chloride results in increased expression of FDPS mRNA24612858
C022838nickel chloridenickel chloride results in decreased expression of FDPS mRNA17547211
C028007nickel monoxidenickel monoxide results in increased expression of FDPS mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of FDPS mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of FDPS protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FDPS mRNA20971185
C464660obeticholic acidobeticholic acid results in decreased expression of FDPS mRNA27939613
D019319Okadaic AcidOkadaic Acid results in decreased expression of FDPS mRNA28939011
D009853OmeprazoleOmeprazole affects the expression of FDPS mRNA19483382
D010126OzoneOzone results in decreased expression of FDPS mRNA25838073
D017239PaclitaxelFDPS mRNA results in increased susceptibility to Paclitaxel16322897
C019248pamidronatepamidronate results in decreased activity of FDPS protein11160603|1832572
C019248pamidronatepamidronate results in decreased activity of FDPS protein18325729
D052638Particulate MatterParticulate Matter results in decreased expression of FDPS mRNA24769257
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FDPS protein26178269
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of FDPS mRNA19429403|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FDPS mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FDPS mRNA17681415|1942940
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of FDPS mRNA17097637
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FDPS mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of FDPS mRNA19136022
D010634PhenobarbitalPhenobarbital results in increased expression of FDPS mRNA19162173
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of FDPS mRNA27756839
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FDPS mRNA15728792
C049032pinosylvinpinosylvin results in decreased expression of FDPS mRNA23333577
C006253pirinixic acidpirinixic acid affects the expression of FDPS mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of FDPS mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of FDPS mRNA15302862|1846767
C006253pirinixic acidpirinixic acid results in increased expression of FDPS protein15226431
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of FDPS mRNA]18467677
C006253pirinixic acidpirinixic acid affects the expression of FDPS mRNA19483382
C006253pirinixic acidpirinixic acid results in increased expression of FDPS mRNA19162173
D010894PiroxicamPiroxicam results in decreased expression of FDPS mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in increased expression of FDPS mRNA23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of FDPS protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FDPS mRNA28903501
C045362prochlorazprochloraz results in increased expression of FDPS mRNA21470553
D011374ProgesteroneProgesterone results in increased expression of FDPS mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of FDPS mRNA18070364
D011374ProgesteroneProgesterone affects the expression of FDPS mRNA17251523
C045950propiconazolepropiconazole results in decreased expression of FDPS mRNA23339182
D011441PropylthiouracilPropylthiouracil affects the expression of FDPS mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of FDPS mRNA24780913
D011794QuercetinQuercetin results in decreased expression of FDPS mRNA21632981
C502851quinocetonequinocetone results in increased expression of FDPS mRNA27046791
D015125OxyquinolineOxyquinoline results in decreased expression of FDPS mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FDPS mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [Simvastatin results in increased expression of FDPS mRNA]23386644
D015474IsotretinoinIsotretinoin results in decreased expression of FDPS mRNA20436886
D000068296Risedronate SodiumRisedronate Sodium binds to FDPS protein16684881
D000068296Risedronate SodiumRisedronate Sodium results in decreased activity of FDPS protein11160603
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FDPS mRNA16054899
D012822Silicon DioxideSilicon Dioxide results in increased expression of FDPS mRNA25351596
D019821Simvastatinresveratrol inhibits the reaction [Simvastatin results in increased expression of FDPS mRNA]23386644
D019821SimvastatinSimvastatin results in increased expression of FDPS mRNA23386644
C009277sodium arsenatesodium arsenate results in increased expression of FDPS mRNA23922661
D012969Sodium FluorideSodium Fluoride results in decreased expression of FDPS protein28918527
D012999SomanSoman results in decreased expression of FDPS mRNA19281266
D053260SootSoot results in decreased expression of FDPS mRNA22461453
D053260SootSoot results in increased expression of FDPS mRNA22461453
C025462sulindac sulfidesulindac sulfide results in decreased expression of FDPS mRNA16184548
D014284TriiodothyronineTriiodothyronine results in increased expression of FDPS mRNA15953391
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FDPS mRNA20106945|2129612
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FDPS mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDPS mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of FDPS mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FDPS mRNA16054898
D013853ThioacetamideThioacetamide affects the expression of FDPS mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of FDPS mRNA27760801
C423915TO-901317TO-901317 results in increased expression of FDPS mRNA15302862
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FDPS mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FDPS mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FDPS gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FDPS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FDPS mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FDPS mRNA"26179874
C406224valdecoxibvaldecoxib results in increased expression of FDPS mRNA24136188
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of FDPS mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of FDPS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FDPS mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of FDPS gene29154799
D014635Valproic AcidValproic Acid affects the expression of FDPS mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of FDPS mRNA22045034
D014752Vinyl ChlorideVinyl Chloride results in increased expression of FDPS mRNA18579281
C087958YM 529YM 529 results in decreased activity of FDPS protein11160603
C088658zoledronic acidzoledronic acid binds to FDPS protein16684881
C088658zoledronic acidzoledronic acid results in decreased activity of FDPS protein11160603|1720820
C088658zoledronic acid[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate19699819
C088658zoledronic acidzoledronic acid results in increased activity of FDPS protein12846887
C088658zoledronic acidzoledronic acid results in increased expression of FDPS mRNA24714768
C088658zoledronic acidzoledronic acid results in decreased activity of FDPS protein18325729
C088658zoledronic acidzoledronic acid results in increased expression of FDPS mRNA18325729

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004161dimethylallyltranstransferase activity-IBA21873635  
GO:0004161dimethylallyltranstransferase activity-TAS-  
GO:0004337geranyltranstransferase activity-IBA21873635  
GO:0004337geranyltranstransferase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0016032viral process-IEA-  
GO:0033384geranyl diphosphate biosynthetic process-IEA-  
GO:0045337farnesyl diphosphate biosynthetic process-IBA21873635  
GO:0045337farnesyl diphosphate biosynthetic process-IEA-  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00900Terpenoid backbone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25891301Mucosal Manifestations in the Edentulous Maxilla with Implant Supported Prostheses: Clinical Results from a Well-Maintained Patient Cohort. (2016 Aug)Ebinger AClin Implant Dent Relat Res