Gene: LNX2

222484
PDZRN1
ligand of numb-protein X 2
protein-coding
13q12.2
Ensembl:ENSG00000139517 MIM:609733 Vega:OTTHUMG00000016634 UniprotKB:Q8N448
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.334e-1 (AD)  5.826e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06394460chr13:28130393LNX26.510e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDFY10.83
SCYL20.818
CTDSPL20.814
EDEM10.808
DIS30.808
SEC24B0.806
FAM160B10.797
TBC1D230.794
MED230.793
IREB20.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.43
OR4F29-0.414
S100A1-0.269
BTBD17-0.249
NEU4-0.236
PLA2G5-0.232
C16orf74-0.22
GSX1-0.217
NXNL1-0.216
NR0B1-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of LNX2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LNX2 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LNX2 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LNX2 gene27153756
D001280AtrazineAtrazine results in increased expression of LNX2 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of LNX2 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LNX2 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of LNX2 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of LNX2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of LNX2 mRNA25562108
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LNX2 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of LNX2 mRNA27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LNX2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of LNX2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of LNX2 mRNA19167457
C039281furanfuran results in increased methylation of LNX2 gene22079235
D005897GlafenineGlafenine results in decreased expression of LNX2 mRNA24136188
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of LNX2 mRNA25270620
C410337K 7174K 7174 results in increased expression of LNX2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of LNX2 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LNX2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LNX2 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LNX2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LNX2 mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LNX2 mRNA"29244179
C028007nickel monoxidenickel monoxide results in decreased expression of LNX2 mRNA19167457
D010634PhenobarbitalPhenobarbital results in decreased expression of LNX2 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of LNX2 mRNA23811191
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of LNX2 mRNA21334430
D011441PropylthiouracilPropylthiouracil results in increased expression of LNX2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of LNX2 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LNX2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LNX2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of LNX2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LNX2 mRNA22298810
C012589trichostatin Atrichostatin A affects the expression of LNX2 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LNX2 mRNA"26179874
D014520UrethaneUrethane results in increased expression of LNX2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of LNX2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LNX2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22458338  23088713  27107012  
GO:0030165PDZ domain binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0051260protein homooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26829059Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study. (2015)Sayols-Baixeras SEpigenetics