Gene: ALDH9A1

223
ALDH4|ALDH7|ALDH9|E3|TMABADH
aldehyde dehydrogenase 9 family member A1
protein-coding
1q24.1
Ensembl:ENSG00000143149 MIM:602733 Vega:OTTHUMG00000034677 UniprotKB:P49189
NG_012256.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.721e-1 (AD)  4.877e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLUD10.938
HSDL20.922
ALDH6A10.913
MSI20.912
GOLIM40.91
HADHB0.908
ADD30.906
ALDH7A10.905
GPR137B0.902
PON20.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.611
OR4F29-0.592
RHO-0.306
QRFPR-0.294
ADTRP-0.29
NPBWR2-0.287
CACNA1F-0.284
PROKR2-0.282
TRABD2A-0.282
OPRD1-0.28

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALDH9A1 mRNA"20056577
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH9A1 mRNA"21346803
C0065094-aminobutyraldehydeALDH9A1 protein results in increased metabolism of 4-aminobutyraldehyde8645224
D000079AcetaldehydeALDH9A1 protein results in increased oxidation of Acetaldehyde18940187
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH9A1 mRNA22285649
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH9A1 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH9A1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH9A1 mRNA]17585979
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog affects the expression of ALDH9A1 protein26072098|2659704
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ALDH9A1 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALDH9A1 mRNA16483693
D001115ArecolineArecoline results in decreased expression of ALDH9A1 mRNA17682004
D001280AtrazineAtrazine results in increased expression of ALDH9A1 mRNA25929836
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of ALDH9A1 protein modified form24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH9A1 mRNA20127859
C006780bisphenol Abisphenol A results in increased expression of ALDH9A1 mRNA25181051
C032036bromobenzenebromobenzene metabolite binds to ALDH9A1 protein17305373
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALDH9A1 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALDH9A1 mRNA23741332
D002110CaffeineCaffeine results in increased expression of ALDH9A1 mRNA20864626
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH9A1 gene20938992
C019304ciprofibrateciprofibrate results in increased expression of ALDH9A1 mRNA17998271
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH9A1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ALDH9A1 mRNA22496397
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH9A1 mRNA]17585979
D002994ClofibratePPARA protein affects the reaction [Clofibrate results in increased expression of ALDH9A1 mRNA]22496397
D002995Clofibric AcidClofibric Acid results in increased expression of ALDH9A1 mRNA17998271
D003300CopperCopper results in decreased expression of ALDH9A1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ALDH9A1 mRNA19549813
D003407CreosoteCreosote results in increased expression of ALDH9A1 mRNA19389177
D016572CyclosporineCyclosporine results in decreased expression of ALDH9A1 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH9A1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ALDH9A1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ALDH9A1 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of ALDH9A1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ALDH9A1 mRNA17998271
D000431EthanolEthanol results in increased expression of ALDH9A1 mRNA28069986
D005485FlutamideFlutamide results in increased expression of ALDH9A1 protein17311803
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH9A1 gene20938992
D005897GlafenineGlafenine results in decreased expression of ALDH9A1 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ALDH9A1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH9A1 mRNA25613284
D007854LeadLead results in decreased expression of ALDH9A1 mRNA19921347
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ALDH9A1 mRNA26667767
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH9A1 gene20938992
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of ALDH9A1 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ALDH9A1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ALDH9A1 mRNA20864626
D015741MetriboloneMetribolone results in increased expression of ALDH9A1 protein17152098
D052998MicrocystinsMicrocystins results in decreased expression of ALDH9A1 protein22430071
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of ALDH9A1 mRNA20864626
C053320n-butoxyacetaldehydeALDH9A1 protein results in increased oxidation of n-butoxyacetaldehyde18940187
D009930Organic ChemicalsOrganic Chemicals results in decreased expression of ALDH9A1 mRNA20526952
D017239PaclitaxelPaclitaxel results in increased expression of ALDH9A1 protein15907983
D000073878Palm OilPalm Oil results in decreased expression of ALDH9A1 mRNA18042831
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of ALDH9A1 protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ALDH9A1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALDH9A1 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALDH9A1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ALDH9A1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALDH9A1 mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ALDH9A1 mRNA]18467677
D010578PetroleumPetroleum affects the expression of ALDH9A1 mRNA25208076
C006253pirinixic acidpirinixic acid results in increased expression of ALDH9A1 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ALDH9A1 mRNA]17950772|1846767
D010936Plant ExtractsPlant Extracts results in increased expression of ALDH9A1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of ALDH9A1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of ALDH9A1 mRNA21565894
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ALDH9A1 mRNA26667767
C089730rosiglitazonerosiglitazone affects the expression of ALDH9A1 protein21347706
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of ALDH9A1 protein modified form24464499
D016559TacrolimusTacrolimus results in decreased expression of ALDH9A1 mRNA25270620
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in decreased expression of ALDH9A1 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDH9A1 mRNA21215274|2172422
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH9A1 mRNA25613284
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ALDH9A1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of ALDH9A1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ALDH9A1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of ALDH9A1 mRNA17292431
D014640VancomycinVancomycin results in increased expression of ALDH9A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ALDH9A1 gene25560391
C025643vinclozolinvinclozolin affects the expression of ALDH9A1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ALDH9A1 mRNA23869203
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of ALDH9A1 mRNA"20526952
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ALDH9A1 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00040283-chloroallyl aldehyde dehydrogenase activity-EXP2925663  
GO:0004029aldehyde dehydrogenase (NAD) activity-IBA21873635  
GO:0004029aldehyde dehydrogenase (NAD) activity-IDA2925663  
GO:0019145aminobutyraldehyde dehydrogenase activity-IBA21873635  
GO:0019145aminobutyraldehyde dehydrogenase activity-IDA2925663  8645224  
GO:00337371-pyrroline dehydrogenase activity-IEA-  
GO:0043878glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity-IEA-  
GO:00471054-trimethylammoniobutyraldehyde dehydrogenase activity-IBA21873635  
GO:00471054-trimethylammoniobutyraldehyde dehydrogenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006081cellular aldehyde metabolic process-IDA8645224  
GO:0042136neurotransmitter biosynthetic process-IDA2925663  
GO:0042445hormone metabolic process-TAS2925663  
GO:0045329carnitine biosynthetic process-IEA-  
GO:0045329carnitine biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IDA2925663  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS2925663  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00053Ascorbate and aldarate metabolism
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa00330Arginine and proline metabolism
hsa00340Histidine metabolism
hsa00380Tryptophan metabolism
hsa00410beta-Alanine metabolism
hsa00561Glycerolipid metabolism
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71262Carnitine synthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology
25073604Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. (2014 Nov)Zhang HHum Genet