Gene: FECH

2235
EPP|FCE
ferrochelatase
protein-coding
18q21.31
Ensembl:ENSG00000066926 MIM:612386 Vega:OTTHUMG00000132740 UniprotKB:P22830
NG_008175.1
PubMed
0   ANCO-SNPs
ND
1   
3.687e-1 (AD)  2.186e-1 (ND)   (Frontal_Cortex)
6.990e-2 (AD)  6.758e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24503881chr18:55253280FECH3.400e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1330.902
CLCN30.892
TERF10.885
TFCP20.884
SCARB20.88
SLC39A90.878
SLC11A20.874
FAF10.871
RNF1700.871
COX150.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.625
OR4F29-0.588
MTRNR2L6-0.386
MTRNR2L9-0.363
MTRNR2L10-0.346
PPBP-0.304
C8orf74-0.301
MTRNR2L3-0.287
MTRNR2L8-0.285
TTLL10-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0099471,2,4-trichlorobenzene"1,2,4-trichlorobenzene results in increased activity of FECH protein"6636202
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of FECH mRNA25596134
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FECH mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FECH mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of FECH mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FECH mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of FECH mRNA25704631
D000622Aminolevulinic Acid[Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron15078340
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FECH mRNA24449571
D001280AtrazineAtrazine results in decreased expression of FECH mRNA22378314
C051597Bandrowski's baseBandrowski's base results in increased expression of FECH mRNA20566472
D019817Benzoic AcidBenzoic Acid results in increased expression of FECH mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FECH mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FECH mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FECH mRNA26496743
C006780bisphenol Abisphenol A results in decreased expression of FECH mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of FECH mRNA29275510
C018475butyraldehydebutyraldehyde results in decreased expression of FECH mRNA26079696
D002104CadmiumCadmium results in increased expression of FECH mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FECH mRNA25596134
D002273CarcinogensCarcinogens results in decreased expression of FECH mRNA22269147
D002330Carmustine[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12950064
C004656chloroacetaldehydechloroacetaldehyde affects the expression of FECH mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of FECH mRNA26272509
D002746ChlorpromazineChlorpromazine results in decreased expression of FECH mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FECH mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FECH gene20938992
C059262cidofovircidofovir results in decreased expression of FECH mRNA25596134
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of FECH mRNA20566472
D004002Clodronic AcidClodronic Acid results in decreased expression of FECH mRNA25596134
D003300CopperCopper results in decreased activity of FECH protein2347080
D019327Copper SulfateCopper Sulfate results in increased expression of FECH mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FECH mRNA25596134
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FECH mRNA24317228
D003976DiazinonDiazinon results in increased methylation of FECH gene22964155
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of FECH mRNA"26496743
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FECH mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FECH mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FECH mRNA25596134
D002945CisplatinCisplatin results in increased expression of FECH mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FECH mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of FECH mRNA19467301
D004041Dietary FatsFECH affects the susceptibility to Dietary Fats17600043
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of FECH mRNA20566472
D004147DioxinsDioxins affects the expression of FECH mRNA20463971
D004221DisulfiramDisulfiram results in increased expression of FECH mRNA20566472
D004317DoxorubicinDoxorubicin results in decreased expression of FECH mRNA26873546
C118739entinostatentinostat results in increased expression of FECH mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FECH protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FECH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FECH mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FECH gene16724327
D005054EugenolEugenol results in increased expression of FECH mRNA20566472
D018120FinasterideFinasteride results in increased expression of FECH mRNA24136188
D005485FlutamideFlutamide results in increased expression of FECH mRNA21126777
D005485FlutamideFlutamide results in decreased expression of FECH mRNA24793618
D005485FlutamideFlutamide results in increased expression of FECH mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FECH mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FECH gene20938992
D005897GlafenineGlafenine results in decreased expression of FECH mRNA24136188
C071834glycidamideglycidamide results in increased expression of FECH mRNA17822822
D006118GriseofulvinGriseofulvin results in decreased activity of FECH protein15078340
D006118Griseofulvin[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron15078340
D006118GriseofulvinGriseofulvin results in increased expression of FECH mRNA10215191
D006118Griseofulvinheme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]15078340
C048849heme arginateheme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]15078340
D006533HeptachlorHeptachlor results in decreased activity of FECH protein9879810
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of FECH mRNA20566472
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FECH mRNA12419474
D007069IfosfamideIfosfamide results in decreased expression of FECH mRNA25596134
D007501Iron[Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron15078340
D007501Iron[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron15078340
D007501Ironheme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]15078340
D007501Iron[Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron15078340
C036643isoeugenolisoeugenol results in increased expression of FECH mRNA20566472
D007538IsoniazidIsoniazid results in decreased expression of FECH protein27438535
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FECH mRNA27392435
D019344Lactic AcidLactic Acid results in increased expression of FECH mRNA20566472
C042720mercuric bromidemercuric bromide results in increased expression of FECH mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of FECH mRNA20353558
D008628MercuryMercury results in decreased activity of FECH protein2347080
D008687MetforminMetformin results in decreased expression of FECH mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FECH mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FECH gene20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased activity of FECH protein2347080
C033069methyl salicylatemethyl salicylate results in increased expression of FECH mRNA20566472
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FECH mRNA"25620056
C051752nefazodonenefazodone results in increased expression of FECH mRNA24136188
C026385n-hexanen-hexane results in increased expression of FECH mRNA20566472
C029938nickel sulfatenickel sulfate results in increased expression of FECH mRNA20566472
C012655nimesulidenimesulide results in increased expression of FECH mRNA24136188
C028842N-methylprotoporphyrin IXN-methylprotoporphyrin IX results in decreased activity of FECH protein27438535
C028842N-methylprotoporphyrin IXN-methylprotoporphyrin IX results in decreased activity of FECH protein22859313
C064976O(6)-benzylguanine[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12950064
D010100OxygenOxygen deficiency results in decreased expression of FECH mRNA25596134
D010269ParaquatParaquat results in increased expression of FECH mRNA15458575
D052638Particulate MatterParticulate Matter results in increased expression of FECH mRNA24769257
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FECH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FECH mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of FECH mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of FECH mRNA17426115
D011162Porphobilinogen[Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron15078340
D0198402-Propanol2-Propanol results in increased expression of FECH mRNA20566472
D012643SeleniumSelenium results in decreased expression of FECH mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of FECH mRNA25879800
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of FECH mRNA20566472
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of FECH mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FECH mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FECH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FECH gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FECH mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FECH mRNA21215274
C024746tobacco tartobacco tar results in increased expression of FECH mRNA19559774
C011559tributyltintributyltin results in decreased activity of FECH protein2347080
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FECH mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of FECH mRNA15458575
D014520UrethaneUrethane results in decreased expression of FECH mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FECH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FECH mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FECH gene25560391
C025643vinclozolinvinclozolin results in increased expression of FECH mRNA21126777
D014810Vitamin EVitamin E results in decreased expression of FECH mRNA19244175
C058069zinc mesoporphyrinFECH protein results in increased chemical synthesis of zinc mesoporphyrin11248690|2347080
C058069zinc mesoporphyrinTGFB1 protein promotes the reaction [FECH protein results in increased chemical synthesis of zinc mesoporphyrin]11248690
C088658zoledronic acidzoledronic acid results in decreased expression of FECH mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004325ferrochelatase activity-IBA21873635  
GO:0004325ferrochelatase activity-IDA8973195  15123683  
GO:0004325ferrochelatase activity-TAS-  
GO:0005515protein binding-IPI15123683  27599036  
GO:0008198ferrous iron binding-TAS1729699  
GO:00515372 iron, 2 sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-TAS1729699  
GO:0006783heme biosynthetic process-IBA21873635  
GO:0006783heme biosynthetic process-TAS-  
GO:0009416response to light stimulus-TAS1376018  
GO:0010288response to lead ion-IEA-  
GO:0017085response to insecticide-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046501protoporphyrinogen IX metabolic process-IDA15123683  
GO:0046685response to arsenic-containing substance-IEA-  
GO:0051597response to methylmercury-IEA-  
GO:0070541response to platinum ion-IEA-  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29307774Liaison between heme metabolism and bioenergetics pathways-a multimodal elucidation for early diagnosis of oral cancer. (2018 Mar)Sarkar RPhotodiagnosis Photodyn Ther