Gene: FEN1

2237
FEN-1|MF1|RAD2
flap structure-specific endonuclease 1
protein-coding
11q12.2
Ensembl:ENSG00000168496 MIM:600393 Vega:OTTHUMG00000168162 UniprotKB:P39748
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.483e-1 (AD)  8.277e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A1AP0.931
PSPC10.93
AAGAB0.924
EIF4E20.915
AFG3L20.913
UBLCP10.911
NIF3L10.91
EBNA1BP20.909
RTN4IP10.908
UCHL50.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L9-0.488
MTRNR2L6-0.468
CSAG1-0.461
KCNE4-0.46
OR4F5-0.46
EVC2-0.445
CLEC2B-0.445
HVCN1-0.445
HEY2-0.444
MTRNR2L10-0.443

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01592IronSmall Molecule7439-89-6ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of FEN1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FEN1 mRNA"21354444|2269881
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of FEN1 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of FEN1 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FEN1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FEN1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FEN1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FEN1 mRNA"23196670
C0067574-biphenylamine4-biphenylamine results in decreased expression of FEN1 mRNA24857880
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of FEN1 mRNA22230336|2570463
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FEN1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FEN1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FEN1 mRNA19770486
C103505AM 251AM 251 results in decreased expression of FEN1 mRNA16500647
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FEN1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of FEN1 mRNA22378314
D001374Azacitidine[Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA18720364
D001379AzathioprineAzathioprine results in decreased expression of FEN1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of FEN1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FEN1 mRNA21802500
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FEN1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of FEN1 mRNA16474171|1916744
D004958EstradiolEstradiol affects the expression of FEN1 mRNA15598610
C044887beta-methylcholinebeta-methylcholine affects the expression of FEN1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of FEN1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FEN1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of FEN1 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of FEN1 mRNA21786754
C515564bromovaninbromovanin results in increased expression of FEN1 protein21419150
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FEN1 mRNA12414654|1533650
D002220CarbamazepineCarbamazepine affects the expression of FEN1 mRNA25979313
D002509CephaloridineCephaloridine results in increased expression of FEN1 mRNA18500788
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FEN1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of FEN1 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FEN1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of FEN1 mRNA19549813
C030123coumarincoumarin results in increased expression of FEN1 mRNA18480146
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FEN1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FEN1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FEN1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of FEN1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of FEN1 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of FEN1 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in increased expression of FEN1 mRNA20106945
D000069439DasatinibDasatinib results in decreased expression of FEN1 mRNA20579391
D015255Idarubicin[Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA28973540
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FEN1 mRNA]27941970
D064730Dexrazoxane[Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA28973540
D003976DiazinonDiazinon results in increased methylation of FEN1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FEN1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FEN1 mRNA21266533
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of FEN1 mRNA]21858171
D002945CisplatinCisplatin results in increased expression of FEN1 mRNA27594783
D002945CisplatinFEN1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of FEN1 mRNA21151649
D004008DiclofenacDiclofenac results in increased expression of FEN1 mRNA26934552
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FEN1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FEN1 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FEN1 mRNA19041683
D002117CalcitriolCalcitriol results in decreased expression of FEN1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FEN1 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of FEN1 mRNA27638505
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of FEN1 mRNA20886546
C070609EMD 53998EMD 53998 analog results in increased expression of FEN1 mRNA24977338
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FEN1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FEN1 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FEN1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FEN1 mRNA16174780
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of FEN1 mRNA18852132
D005472FluorouracilFEN1 affects the susceptibility to Fluorouracil15067352
D005472FluorouracilFluorouracil results in increased expression of FEN1 mRNA15109396
C039281furanfuran results in increased expression of FEN1 mRNA22079235|2553966
D019833GenisteinGenistein results in increased expression of FEN1 mRNA16474171
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of FEN1 mRNA22634610
D017313FenretinideFenretinide results in increased expression of FEN1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FEN1 mRNA12414654|2253961
D007213IndomethacinIndomethacin results in increased expression of FEN1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FEN1 mRNA25613284
D007501IronIron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein]20622253
D007545IsoproterenolIsoproterenol results in increased expression of FEN1 mRNA21335049
C544151jinfukangjinfukang results in increased expression of FEN1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FEN1 mRNA24796395
C410337K 7174K 7174 results in decreased expression of FEN1 mRNA24086573
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of FEN1 mRNA18852132
C045463leflunomideleflunomide results in decreased expression of FEN1 mRNA28988120
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of FEN1 mRNA24810058
D009151Mustard GasMustard Gas results in decreased expression of FEN1 mRNA25102026
C005246myristicinmyristicin results in decreased expression of FEN1 mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FEN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FEN1 mRNA"25554681
D009532NickelNickel results in increased expression of FEN1 mRNA25583101
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of FEN1 mRNA12517797
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of FEN1 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FEN1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FEN1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of FEN1 mRNA26516004
C500026palbociclibpalbociclib results in decreased expression of FEN1 mRNA22869556
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FEN1 protein26879310
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of FEN1 mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of FEN1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of FEN1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of FEN1 mRNA19162173
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of FEN1 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of FEN1 mRNA21858171
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of FEN1 mRNA16474171
C019536potassium bromatepotassium bromate results in decreased expression of FEN1 mRNA22539617
D011374ProgesteroneProgesterone results in decreased expression of FEN1 mRNA16966611
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FEN1 mRNA19167446
C547185riccardin Driccardin D results in decreased expression of FEN1 mRNA24069304
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of FEN1 mRNA"16678137
D012834SilverSilver results in decreased expression of FEN1 mRNA26014281
C017947sodium arsenitesodium arsenite results in decreased expression of FEN1 mRNA12377979
C017947sodium arsenitesodium arsenite results in increased expression of FEN1 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of FEN1 protein19072884
C016104sodium bichromatesodium bichromate results in increased expression of FEN1 mRNA22155349
C016104sodium bichromatesodium bichromate affects the expression of FEN1 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of FEN1 mRNA22561333|2599309
D053260SootSoot results in increased expression of FEN1 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of FEN1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FEN1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FEN1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FEN1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FEN1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FEN1 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FEN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FEN1 mRNA17942748
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FEN1 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FEN1 mRNA25613284
D013792Thalidomide[Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA18720364
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of FEN1 mRNA23825117
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FEN1 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of FEN1 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of FEN1 mRNA16054129|1624948
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FEN1 mRNA19042947
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of FEN1 mRNA26898711
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FEN1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FEN1 mRNA19140230
D014635Valproic AcidValproic Acid results in increased expression of FEN1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FEN1 gene25560391
D014747VinblastineFEN1 protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of FEN1 mRNA26682919
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of FEN1 mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of FEN1 mRNA23825117
D024483Vitamin K 3Vitamin K 3 results in decreased expression of FEN1 mRNA12414654
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of FEN1 mRNA12517797

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IBA21873635  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IMP11986308  
GO:0003684damaged DNA binding-TAS8007985  
GO:0003690double-stranded DNA binding-TAS8131753  
GO:0004519endonuclease activity-TAS8131753  
GO:0004523RNA-DNA hybrid ribonuclease activity-IBA21873635  
GO:0004523RNA-DNA hybrid ribonuclease activity-IDA7961795  
GO:0004527exonuclease activity-TAS9778254  
GO:0005515protein binding-IPI9305916  11430825  11598021  14657243  14688284  15576034  
18499658  18692475  22551069  26496610  26751069  
GO:0008309double-stranded DNA exodeoxyribonuclease activity-TAS8131753  
GO:00084095'-3' exonuclease activity-IDA7961795  
GO:00171085'-flap endonuclease activity-IBA21873635  
GO:00171085'-flap endonuclease activity-IDA18995831  
GO:00171085'-flap endonuclease activity-IMP8621570  11986308  
GO:00171085'-flap endonuclease activity-TAS-  
GO:0030145manganese ion binding-IBA21873635  
GO:0045145single-stranded DNA 5'-3' exodeoxyribonuclease activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0048256flap endonuclease activity-IBA21873635  
GO:0048256flap endonuclease activity-IDA18499658  
GO:0051908double-stranded DNA 5'-3' exodeoxyribonuclease activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-TAS-  
GO:0006260DNA replication-TAS9778254  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-TAS8007985  
GO:0006302double-strand break repair-TAS8131753  
GO:0006309apoptotic DNA fragmentation-IBA21873635  
GO:0007613memory-IBA21873635  
GO:0007613memory-IEA-  
GO:0009650UV protection-TAS8007985  
GO:0032201telomere maintenance via semi-conservative replication-TAS-  
GO:0043137DNA replication, removal of RNA primer-IBA21873635  
GO:0043137DNA replication, removal of RNA primer-IDA18995831  
GO:0045876positive regulation of sister chromatid cohesion-IBA21873635  
GO:0045876positive regulation of sister chromatid cohesion-IMP18499658  
GO:0060041retina development in camera-type eye-IBA21873635  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IDA18499658  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIDA24270157  
GO:0005634nucleus-IDA7961795  18995831  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IDA18995831  
GO:0016020membrane-HDA19946888  
GO:0032991protein-containing complex-IDA25378300  
KEGG ID KEGG Term
hsa03030DNA replication
hsa03410Base excision repair
hsa03450Non-homologous end-joining
Reactome ID Reactome Term Evidence
R-HSA-110362POLB-Dependent Long Patch Base Excision RepairTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-157579Telomere MaintenanceTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-174414Processive synthesis on the C-strand of the telomereTAS
R-HSA-174417Telomere C-strand (Lagging Strand) SynthesisTAS
R-HSA-174437Removal of the Flap Intermediate from the C-strandTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5685939HDR through MMEJ (alt-NHEJ)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-69166Removal of the Flap IntermediateTAS
R-HSA-69183Processive synthesis on the lagging strandTAS
R-HSA-69186Lagging Strand SynthesisTAS
R-HSA-69190DNA strand elongationTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One
21040914FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. (2011 Jan)Kwak JHAtherosclerosis