Gene info: ID 2242

Gene: FES

GENE ID: 2242

Synonyms: FPS

Description: FES proto-oncogene, tyrosine kinase

Gene type: protein-coding

Location: 15q26.1

dbXrefs: Ensembl:ENSG00000182511 MIM:190030 Vega:OTTHUMG00000044456 UniprotKB:P07332

RefSeq: NG_029671.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.886e-1 (AD) 7.759e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg26405020	chr15:91427363	FES		3.700e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EHBP1L1	0.817
SCARF1	0.81
SEMA3F	0.782
NOS3	0.781
BCL3	0.78
VASP	0.78
B4GALT1	0.778
ARPC1B	0.772
F11R	0.771
STK10	0.766

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.331
OR4F5	-0.319
DRD5	-0.31
NKX2-8	-0.27
B3GALT2	-0.265
WNT16	-0.264
TENM1	-0.263
XKR4	-0.25
SPHKAP	-0.25
FIBCD1	-0.244

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FES mRNA"	23146750
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FES mRNA	27153756
D001151	Arsenic	Arsenic affects the methylation of FES gene	25304211
C547126	AZM551248	AZM551248 results in increased expression of FES mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of FES mRNA	23656298
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of FES mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FES mRNA	19770486
C006780	bisphenol A	bisphenol A affects the expression of FES mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FES mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of FES mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of FES mRNA	26079696
D003471	Cuprizone	Cuprizone results in increased expression of FES mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of FES mRNA	25562108
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FES mRNA	28628672
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FES mRNA	27392435
D004026	Dieldrin	Dieldrin results in increased expression of FES mRNA	20438755
C069837	fullerene C60	fullerene C60 results in increased expression of FES mRNA	19167457
C039281	furan	furan results in increased expression of FES mRNA	27387713
C419708	gefitinib	gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]	19885553
C419708	gefitinib	gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]	19885553
C419708	gefitinib	gefitinib results in decreased phosphorylation of FES protein	19885553
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FES mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FES mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FES mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FES mRNA	27392435
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of FES mRNA	12634122
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FES mRNA"	29244179
C568507	N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide	"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of FES protein"	21888390
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FES mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in increased expression of FES mRNA	19167457
C046012	pentanal	pentanal results in increased expression of FES mRNA	26079696
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FES mRNA	19710929
C059514	resveratrol	resveratrol results in increased expression of FES mRNA	25905778
C061133	tamibarotene	tamibarotene affects the expression of FES mRNA	15498508
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FES mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FES mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FES mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FES mRNA	25613284
D024505	Tocopherols	Tocopherols results in increased expression of FES mRNA	17056531
D014212	Tretinoin	Tretinoin results in increased expression of FES mRNA	15498508
D014520	Urethane	Urethane results in decreased expression of FES mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of FES mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of FES gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FES gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	IDA	11509660
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IBA	21873635
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IDA	15485904
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	18046454 21044950 24728074
GO:0005524	ATP binding	-	IEA	-
GO:0008017	microtubule binding	-	IEA	-
GO:0034987	immunoglobulin receptor binding	-	IDA	19001085
GO:0035091	phosphatidylinositol binding	-	IDA	19001085

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001578	microtubule bundle formation	-	IEA	-
GO:0006468	protein phosphorylation	-	TAS	6183005
GO:0006935	chemotaxis	-	IBA	21873635
GO:0007098	centrosome cycle	-	IEA	-
GO:0007155	cell adhesion	-	IBA	21873635
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IBA	21873635
GO:0007275	multicellular organism development	-	TAS	6264598
GO:0008283	cell proliferation	-	TAS	6264598
GO:0008360	regulation of cell shape	-	IMP	11509660 18046454
GO:0010976	positive regulation of neuron projection development	-	IMP	15302586
GO:0016477	cell migration	-	IBA	21873635
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	11509660 15485904
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030155	regulation of cell adhesion	-	IMP	11509660
GO:0031116	positive regulation of microtubule polymerization	-	IMP	15485904
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	IMP	11509660
GO:0043304	regulation of mast cell degranulation	-	IBA	21873635
GO:0043304	regulation of mast cell degranulation	-	IMP	19001085
GO:0045087	innate immune response	-	IBA	21873635
GO:0045595	regulation of cell differentiation	-	IMP	15302586
GO:0045639	positive regulation of myeloid cell differentiation	-	IMP	2656706
GO:0046777	protein autophosphorylation	-	IDA	7687763
GO:0060627	regulation of vesicle-mediated transport	-	TAS	11339827
GO:2000145	regulation of cell motility	-	IMP	18046454
GO:2000251	positive regulation of actin cytoskeleton reorganization	-	IMP	15302586

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	11339827
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005925	focal adhesion	-	IDA	18046454
GO:0015630	microtubule cytoskeleton	-	IDA	15485904
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IBA	21873635
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IDA	18046454 19001085
GO:0031410	cytoplasmic vesicle	colocalizes_with	IDA	11339827

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-399954	Sema3A PAK dependent Axon repulsion	TAS
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	IEA
R-HSA-399956	CRMPs in Sema3A signaling	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28659998	Axial Spondyloarthritis and Cigarette Smoking. (2017)	Kaut IK	Open Rheumatol J
18765423	A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. (2008 Nov)	Lao T	Mutagenesis
24791869	Differences in P50 and prepulse inhibition of the startle reflex between male smokers and non-smokers with first episode schizophrenia without medical treatment. (2014)	Song L	Chin Med J (Engl)