Gene info: ID 2243

Gene: FGA

GENE ID: 2243

Synonyms: Fib2

Description: fibrinogen alpha chain

Gene type: protein-coding

Location: 4q31.3

dbXrefs: Ensembl:ENSG00000171560 MIM:134820 Vega:OTTHUMG00000150330 UniprotKB:P02671

RefSeq: NG_008832.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.702e-1 (AD) 5.093e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FGB	0.946
FGG	0.926
ORM1	0.866
HP	0.793
AMBP	0.772
CRP	0.771
AGXT	0.727
APCS	0.711
ORM2	0.711
APOH	0.676

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PCDHGA5	-0.284
ZNF81	-0.246
NHSL2	-0.239
KRBA2	-0.231
SLX4IP	-0.23
ZNF573	-0.229
ALG11	-0.227
TSSK4	-0.224
RNF169	-0.224
GPATCH2L	-0.223

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00009	Alteplase	BiotechDrug	105857-23-6	Approved	Target
DB00015	Reteplase	BiotechDrug	133652-38-7	Approved\|Investigational	Target
DB00029	Anistreplase	BiotechDrug	81669-57-0	Approved	Target
DB00031	Tenecteplase	BiotechDrug	191588-94-0	Approved	Target
DB00364	Sucralfate	Small Molecule	54182-58-0	Approved	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB04919	Alfimeprase	BiotechDrug	259074-76-5	Investigational	Target
DB05099	Ancrod	Small Molecule	9046-56-4	Approved\|Investigational	Target
DB05675	EP-2104R	BiotechDrug	-	Investigational	Target
DB06245	Lanoteplase	BiotechDrug	171870-23-8	Investigational	Target
DB11311	Prothrombin	BiotechDrug	9001-26-7	Approved	Target
DB13151	Anti-inhibitor coagulant complex	BiotechDrug		Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of FGA mRNA"	17690111
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of FGA mRNA"	19162173
C036423	1-aminomethylphosphonic acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGA mRNA"	20566314
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of FGA mRNA	20566314
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGA mRNA"	19692669
D000082	Acetaminophen	Acetaminophen results in decreased expression of FGA mRNA	27761495\|2906747
D000082	Acetaminophen	Acetaminophen results in increased expression of FGA mRNA	25265579
D000082	Acetaminophen	saikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGA mRNA]	25265579
D000082	Acetaminophen	Acetaminophen results in increased expression of FGA mRNA	17522070
C043377	acetochlor	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGA mRNA"	20566314
D000244	Adenosine Diphosphate	Adenosine Diphosphate results in increased secretion of FGA protein	17303692
D000244	Adenosine Diphosphate	Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein]	17303692
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of FGA mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of FGA protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGA mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FGA gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of FGA mRNA	21757418
D000447	Aldehydes	Aldehydes results in decreased expression of FGA mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGA mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of FGA mRNA"	22863853
D001151	Arsenic	Arsenic affects the methylation of FGA gene	25304211
D001241	Aspirin	Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein]	17303692
D001241	Aspirin	Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein]	17303692
D001241	Aspirin	Aspirin results in decreased secretion of FGA protein	17303692
C406592	azaspiracid	azaspiracid results in decreased expression of FGA mRNA	28939011
D001379	Azathioprine	Azathioprine results in decreased expression of FGA mRNA	22623647
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of FGA mRNA	17690111
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of FGA mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of FGA mRNA	22316170
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of FGA mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of FGA mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGA mRNA	16269432\|1806139
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGA mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FGA mRNA"	26238291
D004958	Estradiol	Estradiol results in decreased expression of FGA mRNA	20106945
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of FGA mRNA	17404688\|1869283
D004958	Estradiol	Estradiol results in increased expression of FGA mRNA	20838740
C095105	bexarotene	bexarotene results in decreased expression of FGA mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased expression of FGA mRNA	26364221
C006780	bisphenol A	bisphenol A affects the expression of FGA mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of FGA mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of FGA mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of FGA mRNA	18804290
C018475	butyraldehyde	butyraldehyde results in decreased expression of FGA mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of FGA mRNA	18804290
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of FGA mRNA	16239168
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of FGA mRNA	18804290
D002725	Chloroform	Chloroform results in increased expression of FGA mRNA	17522070
D002746	Chlorpromazine	[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA	27344345
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FGA mRNA	27344345
D002793	Cholic Acids	[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FGA mRNA	20938992
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FGA mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FGA mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FGA mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FGA mRNA	19549813
D003513	Cycloheximide	Cycloheximide results in decreased expression of FGA protein	444225
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGA mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of FGA mRNA	21163907
D016572	Cyclosporine	Cyclosporine results in increased expression of FGA mRNA	21865292
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of FGA mRNA	24921660
D015084	2,4-Dichlorophenoxyacetic Acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGA mRNA"	20566314
D000069604	Dabigatran	Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]	25138021
D002945	Cisplatin	Cisplatin results in decreased expression of FGA mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of FGA mRNA	28302478
C023635	dienogest	[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	15288212
D004041	Dietary Fats	Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]	25138021
D004041	Dietary Fats	Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]	25138021
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FGA mRNA	17602206
D004317	Doxorubicin	Doxorubicin results in decreased expression of FGA protein	21251210
D004317	Doxorubicin	Doxorubicin results in increased expression of FGA mRNA	22016648
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of FGA mRNA	17522070
C454300	estradiol valerate-dienogest	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12616980\|1261698
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12618251\|1528821
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	14561536
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12618251
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FGA mRNA	17108234
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FGA mRNA	23550701
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12616980\|1261698
D011345	Fenofibrate	PPARA promotes the reaction [Fenofibrate results in decreased expression of FGA mRNA]	10216095
D011345	Fenofibrate	Fenofibrate results in decreased expression of FGA mRNA	10216095
C061365	flusilazole	flusilazole results in increased expression of FGA mRNA	22382673
D005485	Flutamide	Flutamide results in decreased expression of FGA mRNA	24136188
D005492	Folic Acid	Folic Acid results in increased expression of FGA mRNA	17868486
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FGA mRNA	20938992
C039281	furan	furan results in decreased expression of FGA mRNA	15120968\|2553966
C039281	furan	furan results in increased methylation of FGA gene	22079235
D019833	Genistein	Genistein results in increased expression of FGA mRNA	20838740
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12616980\|1261698
D005897	Glafenine	Glafenine results in increased expression of FGA mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of FGA mRNA	22634610
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in decreased expression of FGA mRNA	16206274
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to FGA gene]	20091679
C412815	GW 4064	GW 4064 results in increased expression of FGA mRNA	26655953
D006493	Heparin	Heparin deficiency results in increased cleavage of FGA protein	7895349
D006540	Herbicides	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGA mRNA"	20566314
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of FGA mRNA	20566314
C029424	hydrazine	hydrazine results in increased expression of FGA mRNA	15282401
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole results in decreased expression of FGA mRNA"	18061397
C544151	jinfukang	jinfukang results in decreased expression of FGA mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of FGA mRNA	24086573
D007840	Latex	Latex promotes the reaction [Lipopolysaccharides results in increased expression of FGA protein]	18938192
C008261	lead acetate	lead acetate results in decreased expression of FGA mRNA	25270620
D008070	Lipopolysaccharides	Latex promotes the reaction [Lipopolysaccharides results in increased expression of FGA protein]	18938192
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of FGA protein	19367693
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FGA protein	18938192
C008340	mecoprop	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGA mRNA"	20566314
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of FGA mRNA	20353558
D008701	Methapyrilene	Methapyrilene results in decreased expression of FGA mRNA	15120968
D008713	Methimazole	Methimazole results in increased expression of FGA mRNA	22504374
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of FGA mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of FGA mRNA	15120968
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of FGA mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FGA mRNA	23179753
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of FGA mRNA	27544571
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of FGA mRNA	24128854
D009020	Morphine	Morphine affects the secretion of FGA protein modified form	24855564
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of FGA mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FGA mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FGA mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FGA mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of FGA mRNA	20974703
D015058	1-Naphthylisothiocyanate	FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate	21356363
D015058	1-Naphthylisothiocyanate	[FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of CCL2 mRNA	21356363
D015058	1-Naphthylisothiocyanate	[FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of CXCL1 mRNA	21356363
D015058	1-Naphthylisothiocyanate	[FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of CXCL2 mRNA	21356363
D015058	1-Naphthylisothiocyanate	[FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of EGR1 mRNA	21356363
D015058	1-Naphthylisothiocyanate	FGA protein affects the susceptibility to 1-Naphthylisothiocyanate	20974703
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of FGA mRNA	17522070
D010866	Natamycin	Natamycin results in increased expression of FGA mRNA	22863853
C051752	nefazodone	nefazodone results in decreased expression of FGA mRNA	24136188
D009532	Nickel	FGA protein binds to Nickel	23896426
C012655	nimesulide	nimesulide results in decreased expression of FGA mRNA	24136188
D009640	Norethindrone	[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	14561536
C017576	norgestimate	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12618251
D016912	Levonorgestrel	[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]	12618251\|1528821
D009761	Nystatin	Nystatin results in increased expression of FGA mRNA	22863853
C025589	ochratoxin A	ochratoxin A results in decreased expression of FGA mRNA	29274910
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in decreased expression of FGA mRNA	24888373
D052638	Particulate Matter	Particulate Matter results in increased expression of FGA protein	17520064
C046012	pentanal	pentanal results in decreased expression of FGA mRNA	26079696
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of FGA mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of FGA mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FGA mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FGA protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of FGA mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FGA mRNA	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGA mRNA]	18467677
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FGA mRNA	18804290
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FGA mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of FGA mRNA	26794494
D010634	Phenobarbital	Phenobarbital results in increased expression of FGA mRNA	12082028
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of FGA mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of FGA mRNA	16221962\|2081375
C006253	pirinixic acid	pirinixic acid results in decreased expression of FGA mRNA	12832660\|1916217
D010936	Plant Extracts	Plant Extracts results in decreased expression of FGA mRNA	18061397
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in decreased expression of FGA mRNA	24888373
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of FGA mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FGA mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of FGA mRNA	19162173
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of FGA mRNA	17404688\|1869283
C005556	propionaldehyde	propionaldehyde results in decreased expression of FGA mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of FGA mRNA	22504374\|2478091
D011794	Quercetin	Quercetin results in decreased expression of FGA mRNA	21632981
D011802	Quinidine	Quinidine results in increased expression of FGA mRNA	17522070
D012402	Rotenone	Rotenone results in increased expression of FGA mRNA	22016648
C025759	saikosaponin	saikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGA mRNA]	25265579
D012715	Sesame Oil	Sesame Oil results in increased expression of FGA mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FGA mRNA	25895662
D012834	Silver	Silver results in decreased expression of FGA mRNA	26014281
D012906	Smoke	Smoke results in decreased nitrosation of FGA protein	21652289
C009277	sodium arsenate	sodium arsenate results in decreased expression of FGA mRNA	21795629
C017947	sodium arsenite	sodium arsenite affects the methylation of FGA gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of FGA mRNA	25270620
C016104	sodium bichromate	sodium bichromate affects the expression of FGA mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in increased expression of FGA mRNA	25993096
D012460	Sulfasalazine	Sulfasalazine results in increased expression of FGA mRNA	22016648
D016559	Tacrolimus	Tacrolimus results in increased expression of FGA mRNA	21865292
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGA mRNA	11489354\|1806139
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGA protein	16083274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGA mRNA	21889950
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGA mRNA	15703262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGA mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGA mRNA	15644576
D013752	Tetracycline	Tetracycline results in increased expression of FGA mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of FGA mRNA	2440878
D013806	Theophylline	Theophylline results in increased expression of FGA mRNA	17522070
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein]	17303692
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein	17303692
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FGA protein	27189315
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FGA protein	19478969
C066340	tolcapone	tolcapone binds to FGA protein	19783845
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGA mRNA"	17951470
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FGA mRNA"	26179874
C080163	trovafloxacin	[Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of FGA protein	19367693
D014520	Urethane	Urethane results in decreased expression of FGA mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of FGA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGA mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased methylation of FGA gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of FGA mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of FGA protein	17520064
D015032	Zinc	FGA protein binds to Zinc	23896426
D015034	Zinc Oxide	Zinc Oxide analog results in increased expression of FGA mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	contributes_to	IDA	10903502
GO:0005198	structural molecule activity	-	IDA	8910396
GO:0005198	structural molecule activity	-	IMP	10891444
GO:0005515	protein binding	-	IPI	10954706 12706644 15174051 22582013 25241761 26091039
GO:0046872	metal ion binding	-	IEA	-
GO:0050839	cell adhesion molecule binding	contributes_to	IDA	9182580

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002250	adaptive immune response	-	IEA	-
GO:0002576	platelet degranulation	-	TAS	-
GO:0007160	cell-matrix adhesion	-	IDA	10903502
GO:0007596	blood coagulation	-	TAS	-
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0031639	plasminogen activation	-	IDA	16846481
GO:0034116	positive regulation of heterotypic cell-cell adhesion	-	IDA	8100742
GO:0034622	cellular protein-containing complex assembly	-	IDA	8910396
GO:0042730	fibrinolysis	-	IDA	16846481
GO:0043152	induction of bacterial agglutination	-	IDA	24367264
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045087	innate immune response	-	IEA	-
GO:0045907	positive regulation of vasoconstriction	-	IDA	15739255
GO:0045921	positive regulation of exocytosis	-	IDA	19193866
GO:0050714	positive regulation of protein secretion	-	IDA	19193866
GO:0051258	protein polymerization	-	IDA	12706644
GO:0051592	response to calcium ion	-	IDA	6777381
GO:0065003	protein-containing complex assembly	-	IMP	18676163
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IDA	10903502 19193866
GO:0070527	platelet aggregation	-	HMP	23382103
GO:0070527	platelet aggregation	-	IDA	6281794
GO:0072377	blood coagulation, common pathway	-	IMP	12706644
GO:0072378	blood coagulation, fibrin clot formation	-	IDA	16846481
GO:0090277	positive regulation of peptide hormone secretion	-	IDA	19193866
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	-	NAS	24041635
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IDA	10903502
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IDA	10903502

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005577	fibrinogen complex	-	IDA	8910396 16846481 18676163
GO:0005615	extracellular space	-	IDA	6777381
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005938	cell cortex	-	IEA	-
GO:0009897	external side of plasma membrane	-	IDA	6777381
GO:0009986	cell surface	-	IDA	6777381
GO:0031091	platelet alpha granule	-	IDA	6777381
GO:0031093	platelet alpha granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:0072562	blood microparticle	-	HDA	22516433
GO:1903561	extracellular vesicle	-	HDA	24769233

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-140875	Common Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-354192	Integrin alphaIIb beta3 signaling	TAS
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	TAS
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5674135	MAP2K and MAPK activation	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	TAS
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	TAS
R-HSA-6802949	Signaling by RAS mutants	TAS
R-HSA-6802952	Signaling by BRAF and RAF fusions	TAS
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	TAS
R-HSA-6802957	Oncogenic MAPK signaling	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS
R-HSA-9006921	Integrin signaling	TAS
R-HSA-977225	Amyloid fiber formation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25592583	Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations. (2015)	Jeff JM	Pac Symp Biocomput
20110033	The association between class of antipsychotic and rates of hospitalization: results of a retrospective analysis of data from the 2005 Medicare current beneficiary survey. (2009 Dec)	Kennedy J	Clin Ther
29439776	Clinical risk factors for the development of tardive dyskinesia. (2018 Jun 15)	Solmi M	J Neurol Sci
27189315	The human placental proteome is affected by maternal smoking. (2016 Aug)	Huuskonen P	Reprod Toxicol
20709368	The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. (2010 Oct)	Bahadori B	Thromb Res
16466010	[Pharmacogenetics of the local thrombolysis in patients with deep vein thrombosis]. (2005 Jul)	Falkowski A	Pol Arch Med Wewn
18720742	[Glucoregulation in normal weight schizophrenia patients treated by first generation antipsychotics]. (2008 Mar-Apr)	Maric N	Srp Arh Celok Lek