Gene: FGB

2244
HEL-S-78p
fibrinogen beta chain
protein-coding
4q31.3
Ensembl:ENSG00000171564 MIM:134830 Vega:OTTHUMG00000150331 UniprotKB:P02675
NG_008833.1
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.131e-1 (AD)  4.444e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGA0.946
FGG0.905
ORM10.832
HP0.78
CRP0.751
AMBP0.747
AGXT0.721
ORM20.716
APOH0.683
APCS0.658

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHGA5-0.235
PAX3-0.231
SLX4IP-0.23
ACTC1-0.217
A4GNT-0.216
DSC1-0.214
ZNF81-0.214
LINC00319-0.214
NPSR1-0.209
PTRH1-0.209

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00364SucralfateSmall Molecule54182-58-0ApprovedTarget
DB04919AlfimepraseBiotechDrug259074-76-5InvestigationalTarget
DB11311ProthrombinBiotechDrug9001-26-7ApprovedTarget
DB13151Anti-inhibitor coagulant complexBiotechDrugApproved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FGB mRNA"19162173
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGB mRNA"20566314
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of FGB mRNA"20566314
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of FGB mRNA20566314
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FGB mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FGB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of FGB mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FGB mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGB mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FGB mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGB mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FGB mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FGB mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FGB mRNA25265579
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of FGB protein25499718
D000082Acetaminophensaikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGB mRNA]25265579
D000082AcetaminophenAcetaminophen results in increased expression of FGB mRNA17522070|8878780
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGB mRNA"20566314
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of FGB mRNA"20566314
D020106AcrylamideAcrylamide results in decreased expression of FGB mRNA28959563
D000244Adenosine DiphosphateAdenosine Diphosphate results in decreased secretion of FGB protein17303692
D000244Adenosine DiphosphateAspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]17303692
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of FGB mRNA19920212
D000393Air PollutantsAir Pollutants analog results in decreased expression of FGB mRNA21757418
D000393Air PollutantsFGB gene SNP affects the reaction [Air Pollutants results in increased expression of IL6 protein]19750100
D000447AldehydesAldehydes results in decreased expression of FGB mRNA25014914
C103303alitretinoinalitretinoin results in increased expression of FGB protein9869165
D000537Aluminum Oxide"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of FGB protein"25598225
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGB mRNA16483693
C023650anilineaniline results in increased nitrosation of FGB protein21708182
D034341Aristolochic AcidsAristolochic Acids results in increased expression of FGB mRNA21834575
D001241AspirinAspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]17303692
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein]17303692
D001241AspirinAspirin results in decreased secretion of FGB protein17303692
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNA16532367
C406592azaspiracidazaspiracid results in decreased expression of FGB mRNA28939011
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of FGB mRNA19737606
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of FGB mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGB mRNA22178795|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGB mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGB mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGB mRNA20440473
D004958EstradiolEstradiol affects the expression of FGB mRNA23557687
D004958EstradiolEstradiol results in increased expression of FGB mRNA15913882
D004958EstradiolEstradiol results in decreased expression of FGB mRNA19484750
D004958EstradiolEstradiol results in increased expression of FGB mRNA20838740
C095105bexarotenebexarotene results in decreased expression of FGB mRNA16648578
D001629BezafibrateBezafibrate results in increased expression of FGB protein9869165
C006780bisphenol Abisphenol A results in increased expression of FGB mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of FGB mRNA24534842
C006780bisphenol Abisphenol A results in decreased expression of FGB mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of FGB mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FGB mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FGB mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of FGB promoter22457795
D002248Carbon MonoxideFGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]19750100
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGB mRNA26921287
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGB protein17109383
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGB mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FGB mRNA16239168
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FGB mRNA17522070
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of FGB protein25303780
D002509CephaloridineCephaloridine results in increased expression of FGB mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FGB mRNA18804290
C041167chromium nitratechromium nitrate results in increased expression of FGB protein23618972
C019304ciprofibrateciprofibrate results in increased expression of FGB mRNA9869165
C019304ciprofibrateciprofibrate results in increased expression of FGB protein9869165
D002994ClofibrateClofibrate results in increased expression of FGB protein9869165
D002994ClofibrateClofibrate results in decreased expression of FGB mRNA22300585
D002994ClofibrateClofibrate results in increased expression of FGB mRNA17522070
D002995Clofibric AcidClofibric Acid results in increased expression of FGB protein9869165
C018021cobaltous chloridecobaltous chloride results in increased expression of FGB mRNA24386269
D003300CopperCopper results in increased expression of FGB mRNA22465980
D003300CopperCopper results in decreased expression of FGB mRNA21473932
D019327Copper SulfateCopper Sulfate results in decreased expression of FGB mRNA19549813
D003314Corn OilCorn Oil affects the expression of FGB mRNA16360708
D003513CycloheximideCycloheximide results in decreased expression of FGB protein444225
D016572CyclosporineCyclosporine results in decreased expression of FGB mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of FGB mRNA23830897
D016572CyclosporineCyclosporine results in increased expression of FGB mRNA21865292
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGB mRNA"20566314
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of FGB mRNA"20566314
D000069604DabigatranDabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]25138021
D013759DronabinolDronabinol results in increased expression of FGB protein18584336
D013759DronabinolDronabinol results in decreased expression of FGB mRNA16616335
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FGB mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of FGB mRNA17522070
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FGB mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FGB mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of FGB mRNA26934552
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein"25772430
C000944dicrotophosdicrotophos results in decreased expression of FGB mRNA28302478
D004026DieldrinDieldrin results in increased expression of FGB mRNA20438755
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004041Dietary FatsDabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]25138021
D004041Dietary FatsDietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]25138021
D004147DioxinsDioxins affects the expression of FGB mRNA20463971
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNA16532367
D0151175,8,11,14-Eicosatetraynoic Acid"5,8,11,14-Eicosatetraynoic Acid results in increased expression of FGB protein"9869165
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of FGB mRNA17522070
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGB mRNA16954407
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FGB mRNA20227414
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251|1528821
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]14561536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGB mRNA17942748
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
D011345FenofibrateFenofibrate results in decreased expression of FGB mRNA10216095
C006012fenofibric acidfenofibric acid results in increased expression of FGB protein9869165
C039281furanfuran results in decreased expression of FGB mRNA26194646
C039281furanfuran results in increased methylation of FGB gene22079235
D015248GemfibrozilGemfibrozil results in increased expression of FGB mRNA9869165
D015248GemfibrozilGemfibrozil results in increased expression of FGB protein9869165
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of FGB mRNA21782745
D019833GenisteinGenistein results in increased expression of FGB mRNA20838740
D005839GentamicinsGentamicins results in decreased expression of FGB mRNA22061828
D005839GentamicinsGentamicins results in increased expression of FGB mRNA22061828
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12616980|1261698
C010974glyphosateglyphosate results in increased expression of FGB mRNA16532367
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGB mRNA"20566314
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of FGB mRNA"20566314
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of FGB mRNA20566314
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNA16532367
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FGB mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FGB mRNA27392435
C410337K 7174K 7174 results in decreased expression of FGB mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of FGB mRNA15469884
C008261lead acetatelead acetate results in decreased expression of FGB mRNA25270620
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein"25772430
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FGB protein"25772430
D008095Lithocholic Acid[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA21311750
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of FGB mRNA"20566314
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of FGB mRNA"20566314
C042720mercuric bromidemercuric bromide results in increased expression of FGB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of FGB mRNA20353558
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of FGB mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FGB mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FGB mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FGB mRNA27544571
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of FGB mRNA24128854
C523799MRK 003FGB results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FGB mRNA"25554681|2562005
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of FGB protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FGB mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of FGB protein"25598225
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FGB mRNA20974703|2692128
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FGB mRNA17522070
C051752nefazodonenefazodone results in decreased expression of FGB mRNA24136188
D009532NickelNickel results in increased expression of FGB mRNA24084258
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of FGB protein19716841
D009640Norethindrone[Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]14561536
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]12618251|1528821
C025589ochratoxin Aochratoxin A results in decreased expression of FGB mRNA29274910
C025589ochratoxin Aochratoxin A results in decreased expression of FGB protein29274910
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of FGB protein25303780
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of FGB mRNA24888373
D017239PaclitaxelPaclitaxel results in decreased expression of FGB mRNA15585946
D052638Particulate MatterParticulate Matter results in decreased expression of FGB mRNA22178795
C046012pentanalpentanal results in decreased expression of FGB mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of FGB mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of FGB mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGB mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of FGB mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGB mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGB mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of FGB mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FGB mRNA26794494
D010634PhenobarbitalPhenobarbital results in increased expression of FGB mRNA12082028|1916217
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FGB mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of FGB protein9869165
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGB mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of FGB mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of FGB mRNA20813756
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of FGB mRNA24888373
D059808PolyphenolsPolyphenols results in decreased expression of FGB mRNA16293270
C019536potassium bromatepotassium bromate results in increased expression of FGB mRNA23588252
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FGB protein23618972
D011192Potassium DichromatePotassium Dichromate affects the expression of FGB mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FGB mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of FGB mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of FGB mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of FGB mRNA26079696
D011794QuercetinQuercetin results in decreased expression of FGB mRNA21632981
D011802QuinidineQuinidine results in increased expression of FGB mRNA17522070
C052785rebamipiderebamipide results in decreased expression of FGB mRNA15104358
C025759saikosaponinsaikosaponin inhibits the reaction [Acetaminophen results in increased expression of FGB mRNA]25265579
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FGB mRNA25895662
D020123SirolimusSirolimus results in decreased expression of FGB mRNA21865292
D020123SirolimusSirolimus results in increased expression of FGB mRNA21865292
D053260SootSoot results in increased expression of FGB mRNA26551751
D016559TacrolimusTacrolimus results in increased expression of FGB mRNA21865292
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of FGB mRNA18976794
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGB mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGB mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FGB mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FGB mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGB mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGB mRNA15644576
D013752TetracyclineTetracycline results in increased expression of FGB mRNA17522070
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FGB mRNA2440878
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of FGB protein"25852303
D013806TheophyllineTheophylline results in increased expression of FGB mRNA17522070
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein17303692
C009495titanium dioxidetitanium dioxide affects the expression of FGB mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of FGB mRNA27760801
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGB mRNA"17951470
D014204Trenbolone AcetateTrenbolone Acetate affects the expression of FGB protein24072461
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FGB mRNA19448997
C012589trichostatin Atrichostatin A results in decreased expression of FGB mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FGB mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of FGB mRNA29024780
D014425TurpentineTurpentine results in increased expression of FGB mRNA11779202
D014635Valproic AcidValproic Acid results in decreased expression of FGB mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FGB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FGB mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of FGB mRNA28001369
D001335Vehicle EmissionsFGB gene SNP affects the reaction [Vehicle Emissions results in increased expression of IL6 protein]19750100

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor bindingcontributes_toIDA10903502  
GO:0005198structural molecule activity-IDA8910396  
GO:0005515protein binding-IPI12706644  20162731  
GO:0050839cell adhesion molecule bindingcontributes_toIDA9182580  
GO:0051087chaperone binding-IPI19996109  
GO ID GO Term Qualifier Evidence PubMed
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002250adaptive immune response-IEA-  
GO:0002576platelet degranulation-TAS-  
GO:0007160cell-matrix adhesion-IDA10903502  
GO:0007596blood coagulation-TAS-  
GO:0030198extracellular matrix organization-TAS-  
GO:0031639plasminogen activation-IDA16846481  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IDA8100742  
GO:0034622cellular protein-containing complex assembly-IDA8910396  
GO:0042730fibrinolysis-IDA16846481  
GO:0043152induction of bacterial agglutination-IDA24367264  
GO:0044320cellular response to leptin stimulus-IEA-  
GO:0045087innate immune response-IEA-  
GO:0045907positive regulation of vasoconstriction-IDA15739255  
GO:0045921positive regulation of exocytosis-IDA19193866  
GO:0050714positive regulation of protein secretion-IDA19193866  
GO:0051258protein polymerization-IDA12706644  
GO:0051592response to calcium ion-IDA6777381  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA10903502  19193866  
GO:0070527platelet aggregation-IDA6281794  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0072378blood coagulation, fibrin clot formation-IDA16846481  
GO:0090277positive regulation of peptide hormone secretion-IDA19193866  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-NAS24041635  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA10903502  
GO:2000352negative regulation of endothelial cell apoptotic process-IDA10903502  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005577fibrinogen complex-IDA6688356  8910396  16846481  18676163  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA6777381  19996109  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005938cell cortex-IEA-  
GO:0009897external side of plasma membrane-IDA6777381  
GO:0009986cell surface-IDA6777381  
GO:0031091platelet alpha granule-IDA6777381  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-354192Integrin alphaIIb beta3 signalingTAS
R-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins TAS
R-HSA-372708p130Cas linkage to MAPK signaling for integrinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-9006921Integrin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11714857Genetic influences on lipid metabolism trait variability within the Stanislas Cohort. (2001 Nov)Pallaud CJ Lipid Res
16353042[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age]. (2005)Dankovtseva ENKardiologiia
16697386Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort. The role of FGB-455 G/A polymorphism. (2007 Apr)Maumus SAtherosclerosis
25592583Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations. (2015)Jeff JMPac Symp Biocomput
15983960Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. (2005 Jul)Liu YAm J Kidney Dis
17264952Genetic variation in estrogen receptor, C-reactive protein and fibrinogen does not predict the plasma levels of inflammation markers after longterm hormone replacement therapy. (2007 Feb)de Maat MPThromb Haemost
20709368The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. (2010 Oct)Bahadori BThromb Res
19332210Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from the Women's Genome Health Study. (2009 Apr)Albert MAAm Heart J
16466010[Pharmacogenetics of the local thrombolysis in patients with deep vein thrombosis]. (2005 Jul)Falkowski APol Arch Med Wewn
24957141Betaeta-fibrinogen gene promoter A -455 allele associated with poor longterm survival among 55-71 years old Caucasian women in Finnish stroke cohort. (2014 Jun 22)Martiskainen MBMC Neurol
28290798[Combined Effect of Genetic Factors, Age, and Smoking on the Risk of Developing Myocardial Infarction]. (2016 Dec)Osmak G JKardiologiia