Gene info: ID 2246

Gene: FGF1

GENE ID: 2246

Description: fibroblast growth factor 1

Gene type: protein-coding

Location: 5q31.3

dbXrefs: Ensembl:ENSG00000113578 MIM:131220 Vega:OTTHUMG00000059703 UniprotKB:P05230

RefSeq: NC_000005.10

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.321e-1 (AD) 4.533e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1916998	chr5:142694567 (GRCh38.p7)	G>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLA2G16	0.921
RASSF2	0.92
ZCCHC24	0.911
NEK7	0.91
AIF1L	0.909
BCAS1	0.903
PTP4A2	0.903
LPAR1	0.903
MAP4K4	0.898
TP53INP2	0.893

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PCDH8	-0.533
CDH22	-0.53
FBLN7	-0.529
CUX2	-0.525
HCN4	-0.519
TCERG1L	-0.515
OPRD1	-0.51
ASB2	-0.509
KCNK3	-0.508
TPBG	-0.507

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00686	Pentosan Polysulfate	Small Molecule	37300-21-3	Approved	Target
DB01025	Amlexanox	Small Molecule	68302-57-8	Approved\|Investigational	Target
DB01109	Heparin	Small Molecule	9005-49-6	Approved\|Investigational	Target
DB01901	Sucrosofate	Small Molecule	57680-56-5	Experimental	Target
DB01942	Formic Acid	Small Molecule	64-18-6	Approved\|Experimental\|Investigational	Target
DB02264	O2-Sulfo-Glucuronic Acid	Small Molecule		Experimental	Target
DB03959	N,O6-Disulfo-Glucosamine	Small Molecule		Experimental	Target
DB04409	Naphthalene Trisulfonate	Small Molecule		Experimental	Target
DB06589	Pazopanib	Small Molecule	444731-52-6	Approved	Target
DB08238	5-AMINO-NAPHTALENE-2-MONOSULFONATE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of FGF1 mRNA"	26377693
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of FGF1 mRNA"	21920950
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	FGF1 protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15231676
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	FGF1 protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15231676
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein	15695173
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C488185	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	"FGF1 protein inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]"	15231676
C488185	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide	"FGF1 protein inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]"	15231676
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]	16272825
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein	15695173
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739\|1632582
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]	16524372
C018855	2-tert-butylhydroquinone	FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]	16524372
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGF1 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA"	27188386
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of FGF1 mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of FGF1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of FGF1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGF1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of FGF1 mRNA	23630614
C103303	alitretinoin	alitretinoin results in decreased expression of FGF1 mRNA	15982314
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein	1715812
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid results in increased expression of FGF1 protein	15264218
D019856	Ethanolamine	Ethanolamine results in increased activity of FGF1 protein	15802876
C045742	amlexanox	amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein	16300395
C045742	amlexanox	[amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]	16300395
C045742	amlexanox	amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein]	16300395
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGF1 mRNA	16483693
D000968	Antimycin A	Antimycin A results in decreased expression of FGF1 mRNA	19304788
D001151	Arsenic	Arsenic affects the methylation of FGF1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of FGF1 mRNA	21461292
D001280	Atrazine	Atrazine results in increased expression of FGF1 mRNA	25929836
C547126	AZM551248	AZM551248 results in decreased expression of FGF1 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of FGF1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FGF1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FGF1 mRNA	22228805
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of FGF1 mRNA	26496021
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FGF1 mRNA	27685785
C070515	bisindolylmaleimide I	bisindolylmaleimide I promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	21932408
C006780	bisphenol A	bisphenol A results in increased expression of FGF1 mRNA	27022677
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of FGF1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of FGF1 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of FGF1 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of FGF1 mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of FGF1 mRNA	20570719
D000001	Calcimycin	Calcimycin results in increased expression of FGF1 protein	15264218
D002118	Calcium	Calcium results in increased expression of FGF1 protein	15264218
D002217	Carbachol	Carbachol results in increased expression of FGF1 protein	15264218
D002217	Carbachol	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D002217	Carbachol	Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]	15264218
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGF1 mRNA	17484886\|2733941
D002251	Carbon Tetrachloride	FGF1 protein affects the susceptibility to Carbon Tetrachloride	14507672
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of FGF1 mRNA	20706672
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of FGF1 mRNA	18502319
D002994	Clofibrate	Clofibrate results in decreased expression of FGF1 mRNA	17585979
D003008	Cloprostenol	Cloprostenol results in increased expression of FGF1 mRNA	14991729
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FGF1 mRNA	24386269
D003300	Copper	Copper affects the secretion of [FGF1 protein binds to SYT1 protein binds to S100A13 protein]	16262243
C029892	cupric chloride	[amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]	16300395
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGF1 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in decreased expression of FGF1 mRNA	19770486
C093628	cyproconazole	cyproconazole results in decreased expression of FGF1 mRNA	22334560
D013759	Dronabinol	Dronabinol results in increased expression of FGF1 mRNA	17578508
D003976	Diazinon	Diazinon results in increased methylation of FGF1 gene	22964155
D003976	Diazinon	Diazinon affects the expression of FGF1 mRNA	22546817
D003976	Diazinon	Diazinon results in decreased expression of FGF1 mRNA	19130878
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FGF1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FGF1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FGF1 mRNA	22023808
D004008	Diclofenac	Diclofenac results in decreased expression of FGF1 mRNA	26934552
D004026	Dieldrin	Dieldrin affects the expression of FGF1 mRNA	19130878\|2254681
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats affects the expression of FGF1 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of FGF1 mRNA	18042831\|1903023
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19030233
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of FGF1 mRNA	18691550
D004052	Diethylnitrosamine	MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FGF1 mRNA]	18691550
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of FGF1 gene	23968726
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNA	22129741
D004237	Diuron	Diuron results in decreased expression of FGF1 mRNA	21551480
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of FGF1 mRNA	21040762
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of FGF1 mRNA"	15919760
D017984	Enoxaparin	Enoxaparin results in increased activity of FGF1 protein	16260867
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of FGF1 mRNA	20706672
C109476	epoxiconazole	epoxiconazole results in decreased expression of FGF1 mRNA	22334560
D000431	Ethanol	Ethanol results in increased expression of FGF1 mRNA	28789864
C082360	fipronil	fipronil results in increased expression of FGF1 mRNA	23962444
D005473	Fluoxetine	Fluoxetine results in increased expression of FGF1 mRNA	17033635
D005485	Flutamide	Flutamide results in decreased expression of FGF1 mRNA	24793618
C039281	furan	furan results in decreased expression of FGF1 mRNA	25539665
D019833	Genistein	Genistein results in decreased expression of FGF1 mRNA	20706672
D005978	Glutathione	2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]	16524372
D005978	Glutathione	FGF1 protein results in increased abundance of and results in increased secretion of Glutathione	16524372
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA	19695318
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans binds to FGF1 protein	12512896
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	15767480
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR1 protein]	10336501
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR4 protein]	10336501
D006493	Heparin	[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein	16219767
D006493	Heparin	Heparin analog promotes the reaction [FGF1 protein binds to FGF1 protein]	16219767
D006493	Heparin	Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]	1379594
D006493	Heparin	Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]	1379594
D006493	Heparin	Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]	10336501
D006493	Heparin	[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein	10860838
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]	14966081
D006493	Heparin	Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]	14966081
D006493	Heparin	Heparin promotes the reaction [FGF1 protein results in increased expression of FGF1 protein]	8576258
D006493	Heparin	FGF1 protein binds to FGFR2 protein binds to Heparin	15165853\|1622336
D006493	Heparin	Heparin affects the activity of FGF1 protein	9174673
D006493	Heparin	Heparin analog binds to and results in decreased degradation of FGF1 protein	9174673
D006493	Heparin	Heparin binds to FGF1 protein	15632177
D006493	Heparin	phosphomannopentaose sulfate inhibits the reaction [Heparin binds to FGF1 protein]	15632177
D006497	Heparitin Sulfate	FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein	12604602
D006497	Heparitin Sulfate	Heparitin Sulfate analog binds to FGF1 protein	15081013
D006497	Heparitin Sulfate	Heparitin Sulfate analog promotes the reaction [FGF1 protein results in increased activity of FGFR2 protein alternative form]	11714710
D006632	Histamine	Histamine results in increased expression of FGF1 protein	15264218
D017313	Fenretinide	Fenretinide results in decreased expression of FGF1 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of FGF1 mRNA	28973697
D012701	Serotonin	Serotonin results in increased expression of FGF1 protein	15264218
D006861	Hydrogen Peroxide	FGF1 protein results in decreased susceptibility to Hydrogen Peroxide	16222742
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of FGF1 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNA	22129741
C018086	isobutyl nitrite	isobutyl nitrite results in increased expression of FGF1 mRNA	16288974
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FGF1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of FGF1 mRNA	27392435
C057416	KT 5720	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D007736	Kynurenic Acid	Kynurenic Acid results in decreased secretion of FGF1 protein	16392031
D007736	Kynurenic Acid	Kynurenic Acid results in decreased secretion of FGF1 protein	16392031
C008261	lead acetate	lead acetate affects the expression of FGF1 mRNA	21864555
C038753	leptomycin B	leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein	15574884
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FGF1 mRNA	15919760
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGF1 mRNA	26378955
C015977	malealdehyde	FGF1 protein results in decreased secretion of malealdehyde	16222742
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]	26497364
D008727	Methotrexate	Methotrexate results in increased expression of FGF1 mRNA	19192274
D008727	Methotrexate	Methotrexate affects the expression of FGF1 mRNA	18502557
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA	23519560
D008770	Methylnitrosourea	FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]	16011256
D008770	Methylnitrosourea	FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]	16011256
C056218	ML 9	ML 9 inhibits the reaction [FGF1 protein alternative form results in increased phosphorylation of AKT3 protein]	15517595
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FGF1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FGF1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	12540486
D009532	Nickel	Nickel results in decreased expression of FGF1 mRNA	19130878
C022838	nickel chloride	nickel chloride affects the expression of FGF1 mRNA	22546817
C029938	nickel sulfate	nickel sulfate results in decreased expression of FGF1 mRNA	22714537
D009534	Niclosamide	Niclosamide results in decreased expression of FGF1 mRNA	25174399
D009534	Niclosamide	Niclosamide results in decreased expression of FGF1 protein	25174399
D009569	Nitric Oxide	FGF1 protein results in increased abundance of Nitric Oxide	16524372
D009569	Nitric Oxide	PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]	16524372
D009638	Norepinephrine	[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D009638	Norepinephrine	[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA	11742803
D009638	Norepinephrine	KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]	15264218
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]	15264218
C558013	NSC 689534	NSC 689534 results in increased expression of FGF1 mRNA	20971185
D009844	Oligosaccharides	Oligosaccharides binds to and results in decreased degradation of FGF1 protein	9174673
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]	11714710
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR1 protein alternative form]	9174673
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR4 protein]	11714710\|9174673
D009844	Oligosaccharides	Oligosaccharides promotes the reaction [FGF1 protein results in increased activity of FGFR2 protein alternative form]	11714710
C412603	orantinib	orantinib results in decreased activity of FGF1 protein	15739567
C485800	osajin	osajin results in increased expression of FGF1 mRNA	20706672
D000073878	Palm Oil	Palm Oil affects the expression of FGF1 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in increased expression of FGF1 mRNA	18042831
D010269	Paraquat	Paraquat results in increased expression of FGF1 mRNA	16324872
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF1 mRNA"	25510870
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]	16524372
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein]	15773903
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]	15773903
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA]	16524372
C113399	PD 166866	PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C115711	PD 173074	PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]	15709206
D010634	Phenobarbital	Phenobarbital affects the expression of FGF1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased susceptibility to FGF1 protein	1715812
D010634	Phenobarbital	Phenobarbital results in increased expression of FGF1 mRNA	19162173
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate analog binds to FGF1 protein	16366604
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate binds to FGF1 protein	16366604
C120158	phosphomannopentaose sulfate	phosphomannopentaose sulfate inhibits the reaction [Heparin binds to FGF1 protein]	15632177
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of FGF1 gene	23968726
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FGF1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of FGF1 mRNA	17426115\|1830175
D028321	Plant Preparations	Plant Preparations results in increased expression of FGF1 mRNA	26945725
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA	19695318
C474837	pomiferin	pomiferin results in increased expression of FGF1 mRNA	20706672
D011189	Potassium Chloride	Potassium Chloride results in increased expression of FGF1 protein	15264218
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of FGF1 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FGF1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FGF1 mRNA	19162173
C045950	propiconazole	propiconazole results in decreased expression of FGF1 mRNA	22334560
D011433	Propranolol	Propranolol results in increased expression of FGF1 mRNA	15264218
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGF1 mRNA	24780913
C033607	puerarin	puerarin results in increased expression of FGF1 mRNA	20706672
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
D011794	Quercetin	Quercetin results in decreased expression of FGF1 protein	28431985
D017378	Quinolinic Acid	Quinolinic Acid results in decreased secretion of FGF1 protein	16392031
D017378	Quinolinic Acid	Quinolinic Acid results in decreased secretion of FGF1 protein	16392031
C059514	resveratrol	resveratrol results in increased expression of FGF1 mRNA	20706672
D015474	Isotretinoin	Isotretinoin results in decreased expression of FGF1 mRNA	15982314
C089032	rimonabant	rimonabant affects the expression of FGF1 mRNA	19030233
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of FGF1 mRNA]	19030233
C529148	rosavin	rosavin results in increased expression of FGF1 mRNA	20706672
D012402	Rotenone	Rotenone results in decreased expression of FGF1 mRNA	19304788
C085746	rottlerin	rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]	15574884
C093642	SB 203580	SB 203580 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
D000068677	Sildenafil Citrate	Sildenafil Citrate results in increased expression of FGF1 mRNA	20583517
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FGF1 mRNA	25895662
D020123	Sirolimus	Sirolimus inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of FGF1 mRNA	16214533
C105686	SU 5402	SU 5402 inhibits the reaction [FGF1 protein results in increased activity of FGFR3 protein]	14871245
C105686	SU 5402	SU 5402 results in decreased expression of FGF1 mRNA	12421715
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGF1 mRNA	26378955
D014284	Triiodothyronine	[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D014284	Triiodothyronine	AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]	11742803
D014284	Triiodothyronine	[FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA	11742803
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]	11742803
C013698	tallow	tallow affects the expression of FGF1 mRNA	19680557
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of FGF1 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF1 mRNA	21296121
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF1 mRNA	19770486\|2403582
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA	23519560
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased secretion of FGF1 protein	18400376
D013853	Thioacetamide	Thioacetamide results in increased expression of FGF1 mRNA	23411599
D013974	Thyroxine	Thyroxine results in increased expression of FGF1 mRNA	23935926
C009495	titanium dioxide	titanium dioxide affects the expression of FGF1 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in decreased expression of FGF1 mRNA	23557971
D024505	Tocopherols	Tocopherols results in decreased expression of FGF1 mRNA	15878867
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of FGF1 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of FGF1 mRNA	15982314
C113580	U 0126	FGF1 protein inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15231676
C113580	U 0126	FGF1 protein inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15231676
C113580	U 0126	U 0126 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
C113580	U 0126	U 0126 inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]	15121739
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FGF1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGF1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of FGF1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of FGF1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of FGF1 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FGF1 mRNA	26682919
C009687	wortmannin	wortmannin results in decreased activity of FGF1 protein	15695173
C009687	wortmannin	wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]	15121739
D015032	Zinc	Zinc results in increased expression of FGF1 mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of FGF1 mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005104	fibroblast growth factor receptor binding	-	IMP	18441324
GO:0005104	fibroblast growth factor receptor binding	-	IPI	10830168 12815063
GO:0005178	integrin binding	-	IDA	18441324
GO:0005515	protein binding	-	IPI	10618369 10830168 14732692 18441324 25241761
GO:0008083	growth factor activity	-	IDA	20145243
GO:0008201	heparin binding	-	IDA	20145243
GO:0008201	heparin binding	-	IMP	18441324
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0030544	Hsp70 protein binding	-	IEA	-
GO:0044548	S100 protein binding	-	IPI	11432880
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0000187	activation of MAPK activity	-	IMP	18441324
GO:0001525	angiogenesis	-	IEA	-
GO:0001759	organ induction	-	IEA	-
GO:0007165	signal transduction	-	NAS	3778488
GO:0007275	multicellular organism development	-	TAS	10903182
GO:0008283	cell proliferation	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IGI	8663044 18187602
GO:0008284	positive regulation of cell proliferation	-	IMP	18441324 23469107
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IDA	20145243
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IGI	8663044 18187602
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IMP	18441324
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IPI	10830168
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0009653	anatomical structure morphogenesis	-	TAS	1693186
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010595	positive regulation of endothelial cell migration	-	IMP	23469107
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0030154	cell differentiation	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0030335	positive regulation of cell migration	-	IDA	20145243
GO:0030335	positive regulation of cell migration	-	IMP	18441324
GO:0032148	activation of protein kinase B activity	-	IMP	18441324
GO:0034605	cellular response to heat	-	IDA	12746488
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0043406	positive regulation of MAP kinase activity	-	IDA	16756958
GO:0045542	positive regulation of cholesterol biosynthetic process	-	IDA	19229075
GO:0045766	positive regulation of angiogenesis	-	IDA	20145243
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	19229075
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	-
GO:0051781	positive regulation of cell division	-	IDA	20145243
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0060681	branch elongation involved in ureteric bud branching	-	IDA	11731227
GO:0072163	mesonephric epithelium development	-	IDA	11731227
GO:1901509	regulation of endothelial tube morphogenesis	-	IMP	23469107
GO:1902533	positive regulation of intracellular signal transduction	-	IDA	19229075
GO:1903672	positive regulation of sprouting angiogenesis	-	IMP	23469107
GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	-	IDA	16756958

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	12746488
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	18400376
GO:0005730	nucleolus	-	IEA	-
GO:0005829	cytosol	-	IDA	12746488
GO:0005938	cell cortex	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1226099	Signaling by FGFR in disease	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643685	Disease	IEA
R-HSA-1839122	Signaling by activated point mutants of FGFR1	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	IEA
R-HSA-1839130	Signaling by activated point mutants of FGFR3	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190239	FGFR3 ligand binding and activation	TAS
R-HSA-190241	FGFR2 ligand binding and activation	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190322	FGFR4 ligand binding and activation	TAS
R-HSA-190370	FGFR1b ligand binding and activation	TAS
R-HSA-190371	FGFR3b ligand binding and activation	TAS
R-HSA-190372	FGFR3c ligand binding and activation	TAS
R-HSA-190373	FGFR1c ligand binding and activation	TAS
R-HSA-190375	FGFR2c ligand binding and activation	TAS
R-HSA-190377	FGFR2b ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2033514	FGFR3 mutant receptor activation	TAS
R-HSA-2033519	Activated point mutants of FGFR2	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	TAS
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	TAS
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654699	SHC-mediated cascade:FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654704	SHC-mediated cascade:FGFR3	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	TAS
R-HSA-5654716	Downstream signaling of activated FGFR4	TAS
R-HSA-5654719	SHC-mediated cascade:FGFR4	TAS
R-HSA-5654720	PI-3K cascade:FGFR4	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	IEA
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5655332	Signaling by FGFR3 in disease	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663202	Diseases of signal transduction	IEA
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-8851708	Signaling by FGFR2 IIIa TM	IEA
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29281903	Assessment of FGFR1 Over-Expression and Over-Activity in Lung Cancer Cells: A Toolkit for Anti-FGFR1 Drug Screening. (2018 Feb)	Hu P	Hum Gene Ther Methods
24777817	Sub-toxic nicotine concentrations affect extracellular matrix and growth factor signaling gene expressions in human osteoblasts. (2014 Dec)	Marinucci L	J Cell Physiol
20970515	Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)	Llinas L	Pulm Pharmacol Ther
19968631	Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)	Yang KD	Allergy