Gene: ABCD2

225
ABC39|ALDL1|ALDR|ALDRP|hALDR
ATP binding cassette subfamily D member 2
protein-coding
12q12
Ensembl:ENSG00000173208 MIM:601081 Vega:OTTHUMG00000169337 UniprotKB:Q9UBJ2
NC_000012.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.147e-1 (AD)  4.019e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL60.831
GABRA20.804
FAM171B0.802
LYPD60.777
TTC30A0.777
EPHB10.77
CHRDL10.763
SLC1A40.76
MGAT4C0.751
WIF10.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFN-0.477
GNG8-0.461
BEST3-0.458
SPINK8-0.455
SERPINF2-0.451
TMC8-0.432
LBX2-0.429
PTGER1-0.426
FCER2-0.423
PDE6G-0.422

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of ABCD2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABCD2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ABCD2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ABCD2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ABCD2 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of ABCD2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABCD2 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ABCD2 mRNA20409345
D000639AmitriptylineAmitriptyline results in decreased expression of ABCD2 mRNA22341215
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCD2 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of ABCD2 mRNA"24160326
D001280AtrazineAtrazine results in decreased expression of ABCD2 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of ABCD2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCD2 mRNA20713471
D004958EstradiolEstradiol results in decreased expression of ABCD2 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ABCD2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of ABCD2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ABCD2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ABCD2 mRNA22079614
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABCD2 mRNA27339419
D003471CuprizoneCuprizone results in decreased expression of ABCD2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ABCD2 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of ABCD2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ABCD2 mRNA28628672
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCD2 mRNA]22185406
D003907DexamethasoneDexamethasone results in increased expression of ABCD2 mRNA22185406
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ABCD2 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of ABCD2 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ABCD2 mRNA24535843
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCD2 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ABCD2 mRNA21658437
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which results in decreased expression of ABCD2 mRNA19944135
D004726EndosulfanEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA]26159488
C039281furanfuran results in increased expression of ABCD2 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of ABCD2 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of ABCD2 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCD2 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ABCD2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ABCD2 mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ABCD2 mRNA"24972896
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCD2 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABCD2 mRNA22185406|2589032
D008070LipopolysaccharidesQuercetin affects the reaction [Lipopolysaccharides results in decreased expression of ABCD2 mRNA]22185406
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABCD2 mRNA"26251327
C060893MK-886MK-886 results in increased expression of ABCD2 mRNA18292206
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABCD2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCD2 mRNA"25620056
D009966OrphenadrineOrphenadrine affects the expression of ABCD2 mRNA23665939
C016030pantogabpantogab results in decreased expression of ABCD2 mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of ABCD2 mRNA19136022|2309116
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ABCD2 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of ABCD2 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of ABCD2 mRNA15302862|1537516
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ABCD2 mRNA]20059764
D011441PropylthiouracilPropylthiouracil results in decreased expression of ABCD2 mRNA24780913
D011794QuercetinQuercetin affects the reaction [Lipopolysaccharides results in decreased expression of ABCD2 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of ABCD2 mRNA22185406
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ABCD2 mRNA19073995
D012999SomanSoman results in decreased expression of ABCD2 mRNA19281266
C501413tesaglitazartesaglitazar results in increased expression of ABCD2 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of ABCD2 mRNA21669218
D013749TetrachlorodibenzodioxinEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA]26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCD2 mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCD2 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ABCD2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABCD2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCD2 mRNA21889950|2597527
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ABCD2 mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of ABCD2 mRNA24489787
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ABCD2 mRNA28111298
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of ABCD2 mRNA"22185406
C066340tolcaponetolcapone binds to ABCD2 protein19783845
D014241TrichloroethyleneTrichloroethylene results in increased expression of ABCD2 mRNA25549359
D014303TrinitrotolueneTrinitrotoluene affects the expression of ABCD2 mRNA21346803
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of ABCD2 mRNA12732648
D014635Valproic AcidValproic Acid affects the expression of ABCD2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ABCD2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005324long-chain fatty acid transporter activity-TAS-  
GO:0005515protein binding-IPI10704444  10777694  11883941  
GO:0005524ATP binding-IEA-  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IEA-  
GO:0042803protein homodimerization activity-IDA21145416  
GO ID GO Term Qualifier Evidence PubMed
GO:0000038very long-chain fatty acid metabolic process-IDA10196381  
GO:0006635fatty acid beta-oxidation-IGI21145416  
GO:0015909long-chain fatty acid transport-IEA-  
GO:0032000positive regulation of fatty acid beta-oxidation-IDA10196381  
GO:0042760very long-chain fatty acid catabolic process-IGI21145416  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005777peroxisome-IDA10196381  10329405  21145416  
GO:0005778peroxisomal membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa02010ABC transporters
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26142258Transient Ischemic Attack Fast-track and Long-Term Stroke Risk: Role of Diffusion-Weighted Magnetic Resonance Imaging. (2015 Sep)Anticoli SJ Stroke Cerebrovasc Dis
23908061Reduction in early stroke risk in carotid stenosis with transient ischemic attack associated with statin treatment. (2013 Oct)Merwick AStroke
19448791Preventing strokes: the assessment and management of people with transient ischaemic attack. (2009 Apr 24)Gommans JN Z Med J
22720775Higher coated-platelet levels are associated with chronic hypertension in patients with transient ischemic attack. (2013)Prodan CIPlatelets